Correlation between elevated maternal serum alpha-fetoprotein and ischemic placental disease: a retrospective cohort study
Background To evaluate the correlation between elevated maternal serum alpha-fetoprotein (AFP) in the second trimester and ischemic placental disease (IPD). Methods A retrospective cohort study was conducted to analyze the data of 22,574 pregnant women who delivered in the Department of Obstetrics a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2023.2175848 |
| _version_ | 1797681068946489344 |
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| author | Xiaoqing Dai Huimin Zhang Bin Wu Wenwen Ning Yijie Chen Yiming Chen |
| author_facet | Xiaoqing Dai Huimin Zhang Bin Wu Wenwen Ning Yijie Chen Yiming Chen |
| author_sort | Xiaoqing Dai |
| collection | DOAJ |
| description | Background To evaluate the correlation between elevated maternal serum alpha-fetoprotein (AFP) in the second trimester and ischemic placental disease (IPD). Methods A retrospective cohort study was conducted to analyze the data of 22,574 pregnant women who delivered in the Department of Obstetrics at Hangzhou Women’s Hospital from 2018 to 2020, and were screened for maternal serum AFP and free beta-human chorionic gonadotropin (free β-hCG) in the second trimester. The pregnant women were divided into two groups: elevated maternal serum AFP group (n = 334, 1.48%); and normal group (n = 22,240, 98.52%). Mann-Whitney U-test or Chi-square test was used for continuous or categorical data. Modified Poisson regression analysis was used to calculate the relative risk (RR) and 95% confidence interval (CI) of the two groups. Results The AFP MoM and free β-hCG MoM in the elevated maternal serum AFP group were higher than the normal group (2.25 vs. 0.98, 1.38 vs. 1.04) and the differences were all statistically significant (all P < .001). Placenta previa, hepatitis B virus carrying status of pregnant women, premature rupture of membranes (PROM), advanced maternal age (≥35 years), increased free β-hCG MoM, female infants, and low birth weight (RR: 2.722, 2.247, 1.769, 1.766, 1.272, 0.624, 2.554 respectively) were the risk factors for adverse maternal pregnancy outcomes in the elevated maternal serum AFP group. Conclusions Maternal serum AFP levels during the second trimester can monitor IPD, such as IUGR, PROM, and placenta previa. Maternal women with high serum AFP levels are more likely to deliver male fetuses and low birth weight infants. Finally, the maternal age (≥35 years) and hepatitis B carriers also increased maternal serum AFP significantly. |
| first_indexed | 2024-03-11T23:39:37Z |
| format | Article |
| id | doaj.art-1404732151d24bfe9f198957ad121f8b |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:39:37Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-1404732151d24bfe9f198957ad121f8b2023-09-19T16:04:08ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062023-12-0145110.1080/10641963.2023.21758482175848Correlation between elevated maternal serum alpha-fetoprotein and ischemic placental disease: a retrospective cohort studyXiaoqing Dai0Huimin Zhang1Bin Wu2Wenwen Ning3Yijie Chen4Yiming Chen5Zhejiang Chinese Medical UniversityZhejiang Chinese Medical UniversityZhejiang Chinese Medical UniversityZhejiang Chinese Medical UniversityZhejiang Chinese Medical UniversityZhejiang Chinese Medical UniversityBackground To evaluate the correlation between elevated maternal serum alpha-fetoprotein (AFP) in the second trimester and ischemic placental disease (IPD). Methods A retrospective cohort study was conducted to analyze the data of 22,574 pregnant women who delivered in the Department of Obstetrics at Hangzhou Women’s Hospital from 2018 to 2020, and were screened for maternal serum AFP and free beta-human chorionic gonadotropin (free β-hCG) in the second trimester. The pregnant women were divided into two groups: elevated maternal serum AFP group (n = 334, 1.48%); and normal group (n = 22,240, 98.52%). Mann-Whitney U-test or Chi-square test was used for continuous or categorical data. Modified Poisson regression analysis was used to calculate the relative risk (RR) and 95% confidence interval (CI) of the two groups. Results The AFP MoM and free β-hCG MoM in the elevated maternal serum AFP group were higher than the normal group (2.25 vs. 0.98, 1.38 vs. 1.04) and the differences were all statistically significant (all P < .001). Placenta previa, hepatitis B virus carrying status of pregnant women, premature rupture of membranes (PROM), advanced maternal age (≥35 years), increased free β-hCG MoM, female infants, and low birth weight (RR: 2.722, 2.247, 1.769, 1.766, 1.272, 0.624, 2.554 respectively) were the risk factors for adverse maternal pregnancy outcomes in the elevated maternal serum AFP group. Conclusions Maternal serum AFP levels during the second trimester can monitor IPD, such as IUGR, PROM, and placenta previa. Maternal women with high serum AFP levels are more likely to deliver male fetuses and low birth weight infants. Finally, the maternal age (≥35 years) and hepatitis B carriers also increased maternal serum AFP significantly.http://dx.doi.org/10.1080/10641963.2023.2175848alpha-fetoproteinischemic placental diseasepregnancy outcomeretrospective cohort studyrelative risk |
| spellingShingle | Xiaoqing Dai Huimin Zhang Bin Wu Wenwen Ning Yijie Chen Yiming Chen Correlation between elevated maternal serum alpha-fetoprotein and ischemic placental disease: a retrospective cohort study Clinical and Experimental Hypertension alpha-fetoprotein ischemic placental disease pregnancy outcome retrospective cohort study relative risk |
| title | Correlation between elevated maternal serum alpha-fetoprotein and ischemic placental disease: a retrospective cohort study |
| title_full | Correlation between elevated maternal serum alpha-fetoprotein and ischemic placental disease: a retrospective cohort study |
| title_fullStr | Correlation between elevated maternal serum alpha-fetoprotein and ischemic placental disease: a retrospective cohort study |
| title_full_unstemmed | Correlation between elevated maternal serum alpha-fetoprotein and ischemic placental disease: a retrospective cohort study |
| title_short | Correlation between elevated maternal serum alpha-fetoprotein and ischemic placental disease: a retrospective cohort study |
| title_sort | correlation between elevated maternal serum alpha fetoprotein and ischemic placental disease a retrospective cohort study |
| topic | alpha-fetoprotein ischemic placental disease pregnancy outcome retrospective cohort study relative risk |
| url | http://dx.doi.org/10.1080/10641963.2023.2175848 |
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