Recent Advances in Metal-Based NanoEnhancers for Particle Therapy
Radiotherapy is one of the most common therapeutic regimens for cancer treatment. Over the past decade, proton therapy (PT) has emerged as an advanced type of radiotherapy (RT) that uses proton beams instead of conventional photon RT. Both PT and carbon-ion beam therapy (CIBT) exhibit excellent ther...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/13/6/1011 |
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| author | Yao-Chen Chuang Ping-Hsiu Wu Yao-An Shen Chia-Chun Kuo Wei-Jun Wang Yu-Chen Chen Hsin-Lun Lee Jeng-Fong Chiou |
| author_facet | Yao-Chen Chuang Ping-Hsiu Wu Yao-An Shen Chia-Chun Kuo Wei-Jun Wang Yu-Chen Chen Hsin-Lun Lee Jeng-Fong Chiou |
| author_sort | Yao-Chen Chuang |
| collection | DOAJ |
| description | Radiotherapy is one of the most common therapeutic regimens for cancer treatment. Over the past decade, proton therapy (PT) has emerged as an advanced type of radiotherapy (RT) that uses proton beams instead of conventional photon RT. Both PT and carbon-ion beam therapy (CIBT) exhibit excellent therapeutic results because of the physical characteristics of the resulting Bragg peaks, which has been exploited for cancer treatment in medical centers worldwide. Although particle therapies show significant advantages to photon RT by minimizing the radiation damage to normal tissue after the tumors, they still cause damage to normal tissue before the tumor. Since the physical mechanisms are different from particle therapy and photon RT, efforts have been made to ameliorate these effects by combining nanomaterials and particle therapies to improve tumor targeting by concentrating the radiation effects. Metallic nanoparticles (MNPs) exhibit many unique properties, such as strong X-ray absorption cross-sections and catalytic activity, and they are considered nano-radioenhancers (NREs) for RT. In this review, we systematically summarize the putative mechanisms involved in NRE-induced radioenhancement in particle therapy and the experimental results in in vitro and in vivo models. We also discuss the potential of translating preclinical metal-based NP-enhanced particle therapy studies into clinical practice using examples of several metal-based NREs, such as SPION, Abraxane, AGuIX, and NBTXR3. Furthermore, the future challenges and development of NREs for PT are presented for clinical translation. Finally, we propose a roadmap to pursue future studies to strengthen the interplay of particle therapy and nanomedicine. |
| first_indexed | 2024-03-11T06:04:52Z |
| format | Article |
| id | doaj.art-140608147e2a4ff5b3f9b7a7b83a82e1 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-11T06:04:52Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-140608147e2a4ff5b3f9b7a7b83a82e12023-11-17T13:00:16ZengMDPI AGNanomaterials2079-49912023-03-01136101110.3390/nano13061011Recent Advances in Metal-Based NanoEnhancers for Particle TherapyYao-Chen Chuang0Ping-Hsiu Wu1Yao-An Shen2Chia-Chun Kuo3Wei-Jun Wang4Yu-Chen Chen5Hsin-Lun Lee6Jeng-Fong Chiou7Department of Radiation Oncology, Taipei Medical University Hospital, Taipei 110301, TaiwanDepartment of Radiation Oncology, Taipei Medical University Hospital, Taipei 110301, TaiwanDepartment of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, TaiwanDepartment of Radiation Oncology, Taipei Medical University Hospital, Taipei 110301, TaiwanDepartment of Radiation Oncology, Taipei Medical University Hospital, Taipei 110301, TaiwanDepartment of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, TaiwanDepartment of Radiation Oncology, Taipei Medical University Hospital, Taipei 110301, TaiwanDepartment of Radiation Oncology, Taipei Medical University Hospital, Taipei 110301, TaiwanRadiotherapy is one of the most common therapeutic regimens for cancer treatment. Over the past decade, proton therapy (PT) has emerged as an advanced type of radiotherapy (RT) that uses proton beams instead of conventional photon RT. Both PT and carbon-ion beam therapy (CIBT) exhibit excellent therapeutic results because of the physical characteristics of the resulting Bragg peaks, which has been exploited for cancer treatment in medical centers worldwide. Although particle therapies show significant advantages to photon RT by minimizing the radiation damage to normal tissue after the tumors, they still cause damage to normal tissue before the tumor. Since the physical mechanisms are different from particle therapy and photon RT, efforts have been made to ameliorate these effects by combining nanomaterials and particle therapies to improve tumor targeting by concentrating the radiation effects. Metallic nanoparticles (MNPs) exhibit many unique properties, such as strong X-ray absorption cross-sections and catalytic activity, and they are considered nano-radioenhancers (NREs) for RT. In this review, we systematically summarize the putative mechanisms involved in NRE-induced radioenhancement in particle therapy and the experimental results in in vitro and in vivo models. We also discuss the potential of translating preclinical metal-based NP-enhanced particle therapy studies into clinical practice using examples of several metal-based NREs, such as SPION, Abraxane, AGuIX, and NBTXR3. Furthermore, the future challenges and development of NREs for PT are presented for clinical translation. Finally, we propose a roadmap to pursue future studies to strengthen the interplay of particle therapy and nanomedicine.https://www.mdpi.com/2079-4991/13/6/1011particle therapyproton therapyradiosensitizationradioresistancenanomedicinetheranostic |
| spellingShingle | Yao-Chen Chuang Ping-Hsiu Wu Yao-An Shen Chia-Chun Kuo Wei-Jun Wang Yu-Chen Chen Hsin-Lun Lee Jeng-Fong Chiou Recent Advances in Metal-Based NanoEnhancers for Particle Therapy Nanomaterials particle therapy proton therapy radiosensitization radioresistance nanomedicine theranostic |
| title | Recent Advances in Metal-Based NanoEnhancers for Particle Therapy |
| title_full | Recent Advances in Metal-Based NanoEnhancers for Particle Therapy |
| title_fullStr | Recent Advances in Metal-Based NanoEnhancers for Particle Therapy |
| title_full_unstemmed | Recent Advances in Metal-Based NanoEnhancers for Particle Therapy |
| title_short | Recent Advances in Metal-Based NanoEnhancers for Particle Therapy |
| title_sort | recent advances in metal based nanoenhancers for particle therapy |
| topic | particle therapy proton therapy radiosensitization radioresistance nanomedicine theranostic |
| url | https://www.mdpi.com/2079-4991/13/6/1011 |
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