The CWI Pathway: Regulation of the Transcriptional Adaptive Response to Cell Wall Stress in Yeast
Fungi are surrounded by an essential structure, the cell wall, which not only confers cell shape but also protects cells from environmental stress. As a consequence, yeast cells growing under cell wall damage conditions elicit rescue mechanisms to provide maintenance of cellular integrity and fungal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-12-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/4/1/1 |
| _version_ | 1818822411968053248 |
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| author | Ana Belén Sanz Raúl García José M. Rodríguez-Peña Javier Arroyo |
| author_facet | Ana Belén Sanz Raúl García José M. Rodríguez-Peña Javier Arroyo |
| author_sort | Ana Belén Sanz |
| collection | DOAJ |
| description | Fungi are surrounded by an essential structure, the cell wall, which not only confers cell shape but also protects cells from environmental stress. As a consequence, yeast cells growing under cell wall damage conditions elicit rescue mechanisms to provide maintenance of cellular integrity and fungal survival. Through transcriptional reprogramming, yeast modulate the expression of genes important for cell wall biogenesis and remodeling, metabolism and energy generation, morphogenesis, signal transduction and stress. The yeast cell wall integrity (CWI) pathway, which is very well conserved in other fungi, is the key pathway for the regulation of this adaptive response. In this review, we summarize the current knowledge of the yeast transcriptional program elicited to counterbalance cell wall stress situations, the role of the CWI pathway in the regulation of this program and the importance of the transcriptional input received by other pathways. Modulation of this adaptive response through the CWI pathway by positive and negative transcriptional feedbacks is also discussed. Since all these regulatory mechanisms are well conserved in pathogenic fungi, improving our knowledge about them will have an impact in the developing of new antifungal therapies. |
| first_indexed | 2024-12-18T23:23:40Z |
| format | Article |
| id | doaj.art-140694f5bc734623863e1b1dbc97f9ac |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-12-18T23:23:40Z |
| publishDate | 2017-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-140694f5bc734623863e1b1dbc97f9ac2022-12-21T20:47:52ZengMDPI AGJournal of Fungi2309-608X2017-12-0141110.3390/jof4010001jof4010001The CWI Pathway: Regulation of the Transcriptional Adaptive Response to Cell Wall Stress in YeastAna Belén Sanz0Raúl García1José M. Rodríguez-Peña2Javier Arroyo3Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), 28040 Madrid, SpainDepartamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), 28040 Madrid, SpainDepartamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), 28040 Madrid, SpainDepartamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), 28040 Madrid, SpainFungi are surrounded by an essential structure, the cell wall, which not only confers cell shape but also protects cells from environmental stress. As a consequence, yeast cells growing under cell wall damage conditions elicit rescue mechanisms to provide maintenance of cellular integrity and fungal survival. Through transcriptional reprogramming, yeast modulate the expression of genes important for cell wall biogenesis and remodeling, metabolism and energy generation, morphogenesis, signal transduction and stress. The yeast cell wall integrity (CWI) pathway, which is very well conserved in other fungi, is the key pathway for the regulation of this adaptive response. In this review, we summarize the current knowledge of the yeast transcriptional program elicited to counterbalance cell wall stress situations, the role of the CWI pathway in the regulation of this program and the importance of the transcriptional input received by other pathways. Modulation of this adaptive response through the CWI pathway by positive and negative transcriptional feedbacks is also discussed. Since all these regulatory mechanisms are well conserved in pathogenic fungi, improving our knowledge about them will have an impact in the developing of new antifungal therapies.https://www.mdpi.com/2309-608X/4/1/1cell wall integritymitogen-activated protein kinase (MAPK)signal transductiontranscriptiongene expressionantifungal |
| spellingShingle | Ana Belén Sanz Raúl García José M. Rodríguez-Peña Javier Arroyo The CWI Pathway: Regulation of the Transcriptional Adaptive Response to Cell Wall Stress in Yeast Journal of Fungi cell wall integrity mitogen-activated protein kinase (MAPK) signal transduction transcription gene expression antifungal |
| title | The CWI Pathway: Regulation of the Transcriptional Adaptive Response to Cell Wall Stress in Yeast |
| title_full | The CWI Pathway: Regulation of the Transcriptional Adaptive Response to Cell Wall Stress in Yeast |
| title_fullStr | The CWI Pathway: Regulation of the Transcriptional Adaptive Response to Cell Wall Stress in Yeast |
| title_full_unstemmed | The CWI Pathway: Regulation of the Transcriptional Adaptive Response to Cell Wall Stress in Yeast |
| title_short | The CWI Pathway: Regulation of the Transcriptional Adaptive Response to Cell Wall Stress in Yeast |
| title_sort | cwi pathway regulation of the transcriptional adaptive response to cell wall stress in yeast |
| topic | cell wall integrity mitogen-activated protein kinase (MAPK) signal transduction transcription gene expression antifungal |
| url | https://www.mdpi.com/2309-608X/4/1/1 |
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