Cancer co-opts differentiation of B-cell precursors into macrophage-like cells
The tumour microenvironment has been shown to change the phenotypes and functionality of immune cells to enable tumour propagation. Here authors show that cancers can derail B cell development to give rise to macrophage-like cells, contributing to cancer progression and metastasis via disabling loca...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33117-y |
| _version_ | 1818021235868565504 |
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| author | Chen Chen Bongsoo Park Emeline Ragonnaud Monica Bodogai Xin Wang Le Zong Jung-Min Lee Isabel Beerman Arya Biragyn |
| author_facet | Chen Chen Bongsoo Park Emeline Ragonnaud Monica Bodogai Xin Wang Le Zong Jung-Min Lee Isabel Beerman Arya Biragyn |
| author_sort | Chen Chen |
| collection | DOAJ |
| description | The tumour microenvironment has been shown to change the phenotypes and functionality of immune cells to enable tumour propagation. Here authors show that cancers can derail B cell development to give rise to macrophage-like cells, contributing to cancer progression and metastasis via disabling local T cell response. |
| first_indexed | 2024-04-14T08:16:11Z |
| format | Article |
| id | doaj.art-1406e98d4c3841ff8d1d35bc0537f3f8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-14T08:16:11Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1406e98d4c3841ff8d1d35bc0537f3f82022-12-22T02:04:24ZengNature PortfolioNature Communications2041-17232022-09-0113111510.1038/s41467-022-33117-yCancer co-opts differentiation of B-cell precursors into macrophage-like cellsChen Chen0Bongsoo Park1Emeline Ragonnaud2Monica Bodogai3Xin Wang4Le Zong5Jung-Min Lee6Isabel Beerman7Arya Biragyn8Immunoregulation Section, Laboratory of Immunology and Molecular Biology, National Institute on AgingEpigenetics and Stem Cell Aging Unit, Translational Gerontology Branch, National Institute on AgingImmunoregulation Section, Laboratory of Immunology and Molecular Biology, National Institute on AgingImmunoregulation Section, Laboratory of Immunology and Molecular Biology, National Institute on AgingImmunoregulation Section, Laboratory of Immunology and Molecular Biology, National Institute on AgingEpigenetics and Stem Cell Aging Unit, Translational Gerontology Branch, National Institute on AgingWomen’s Malignancies Branch, Center for Cancer Research, National Cancer InstituteEpigenetics and Stem Cell Aging Unit, Translational Gerontology Branch, National Institute on AgingImmunoregulation Section, Laboratory of Immunology and Molecular Biology, National Institute on AgingThe tumour microenvironment has been shown to change the phenotypes and functionality of immune cells to enable tumour propagation. Here authors show that cancers can derail B cell development to give rise to macrophage-like cells, contributing to cancer progression and metastasis via disabling local T cell response.https://doi.org/10.1038/s41467-022-33117-y |
| spellingShingle | Chen Chen Bongsoo Park Emeline Ragonnaud Monica Bodogai Xin Wang Le Zong Jung-Min Lee Isabel Beerman Arya Biragyn Cancer co-opts differentiation of B-cell precursors into macrophage-like cells Nature Communications |
| title | Cancer co-opts differentiation of B-cell precursors into macrophage-like cells |
| title_full | Cancer co-opts differentiation of B-cell precursors into macrophage-like cells |
| title_fullStr | Cancer co-opts differentiation of B-cell precursors into macrophage-like cells |
| title_full_unstemmed | Cancer co-opts differentiation of B-cell precursors into macrophage-like cells |
| title_short | Cancer co-opts differentiation of B-cell precursors into macrophage-like cells |
| title_sort | cancer co opts differentiation of b cell precursors into macrophage like cells |
| url | https://doi.org/10.1038/s41467-022-33117-y |
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