Synthesis of Six-Membered <i>N</i>-Heterocyclic Carbene Precursors Based on Camphor

Synthesis of Six-Membered <i>N</i>-Heterocyclic Carbene Precursors Based on Camphor

The <i>endo</i>- and <i>exo</i>-<i>N</i>-heterocyclic carbene precursors based on camphor were prepared diastereoselectively in five synthetic steps starting from (1<i>S</i>)-(+)-ketopinic acid. The obtained <i>N</i>-heterocyclic carbene pr...

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Bibliographic Details
Main Authors: Jan Šegina, Luka Ciber, Helena Brodnik, Franc Požgan, Jurij Svete, Bogdan Štefane, Uroš Grošelj
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Molecules
Subjects:
ketopinic acid
amidation
reduction
diamines
<i>N</i>-heterocyclic carbene precursors
asymmetric catalysis
Online Access:https://www.mdpi.com/1420-3049/28/24/7973
Description
Summary:The <i>endo</i>- and <i>exo</i>-<i>N</i>-heterocyclic carbene precursors based on camphor were prepared diastereoselectively in five synthetic steps starting from (1<i>S</i>)-(+)-ketopinic acid. The obtained <i>N</i>-heterocyclic carbene precursors were investigated in an asymmetric benzoin reaction. All new compounds were fully characterized, and the absolute configurations were determined via X-ray diffraction and NOESY measurements.
ISSN:1420-3049

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