Generation of “OP7 chimera” defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice

Generation of “OP7 chimera” defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice

Abstract Influenza A virus (IAV) defective interfering particles (DIPs) are considered as new promising antiviral agents. Conventional DIPs (cDIPs) contain a deletion in the genome and can only replicate upon co-infection with infectious standard virus (STV), during which they suppress STV replicati...

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Bibliographic Details
Main Authors: Tanya Dogra, Lars Pelz, Julia D. Boehme, Jan Kuechler, Olivia Kershaw, Pavel Marichal-Gallardo, Maike Baelkner, Marc D. Hein, Achim D. Gruber, Dirk Benndorf, Yvonne Genzel, Dunja Bruder, Sascha Y. Kupke, Udo Reichl
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-47547-1

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