Targeting PTB for Glia-to-Neuron Reprogramming In Vitro and In Vivo for Therapeutic Development in Neurological Diseases

Targeting PTB for Glia-to-Neuron Reprogramming In Vitro and In Vivo for Therapeutic Development in Neurological Diseases

In vivo cell reprogramming of glial cells offers a promising way to generate new neurons in the adult mammalian nervous system. This approach might compensate for neuronal loss occurring in neurological disorders, but clinically viable tools are needed to advance this strategy from bench to bedside....

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Bibliographic Details
Main Authors: Matilde Contardo, Roberta De Gioia, Delia Gagliardi, Giacomo Pietro Comi, Linda Ottoboni, Monica Nizzardo, Stefania Corti
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biomedicines
Subjects:
PTB
reprogramming
neuron
neurodegenerative diseases
Online Access:https://www.mdpi.com/2227-9059/10/2/399

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