Ecotoxicological assessment of amoxicillin trihydrate: Stability, solubility, and acute toxicity for Oreochromis niloticus, Lemna minor, and Daphnia magna
Among the different pharmaceuticals present in water as micro-contaminants, antibiotics are considered an important risk group for the aquatic ecosystem, since their increasing use in human and veterinary medicine could affect the diversity of microorganism communities. This study aims to classify t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Cleaner Chemical Engineering |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772782322000055 |
| _version_ | 1817978378220732416 |
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| author | Alessandra Cristina de Moraes Eduardo Adilson Orlando Ed Johnny da Rosa Prado Ana Carla Coleone de Carvalho Joaquim Gonçalves Machado-Neto Ana Valéria Colnaghi Simionato Marcos Nogueira Eberlin Marco Antonio de Andrade Belo |
| author_facet | Alessandra Cristina de Moraes Eduardo Adilson Orlando Ed Johnny da Rosa Prado Ana Carla Coleone de Carvalho Joaquim Gonçalves Machado-Neto Ana Valéria Colnaghi Simionato Marcos Nogueira Eberlin Marco Antonio de Andrade Belo |
| author_sort | Alessandra Cristina de Moraes |
| collection | DOAJ |
| description | Among the different pharmaceuticals present in water as micro-contaminants, antibiotics are considered an important risk group for the aquatic ecosystem, since their increasing use in human and veterinary medicine could affect the diversity of microorganism communities. This study aims to classify the acute toxicity of amoxicillin trihydrate for organisms of different trophic levels of aquatic biological chains, represented by Oreochromis niloticus (fish), Lemna minor (macrophyte) and Daphnia magna (microcrustacean). For this purpose, amoxicillin trihydrate degradability in water as well as changes in physicochemical characteristics are focused herein. Initial tests were performed to validate the assay, including drug dissolution in M4 medium, drug degradation in various culture media, sensitivity of experimental organisms as well as preliminary drug intoxication test. Upon validation tests, 2.6 g L−1 amoxicillin was determined as the concentration to evaluate the toxicity factor. Static (48 h) and semi-static (168 h) assays were performed. Therefore, amoxicillin trihydrate did not have an acute toxic effect at the concentration of 2.6 g L−1 under the experimental conditions applied to the species Lemna minor, Daphnia magna and Oreochromis niloticus. demonstrating the very low acute toxicity to aquatic organisms at different trophic levels. |
| first_indexed | 2024-04-13T22:29:21Z |
| format | Article |
| id | doaj.art-140889dd9ab4466e87cdbf39ffb1dd0d |
| institution | Directory Open Access Journal |
| issn | 2772-7823 |
| language | English |
| last_indexed | 2024-04-13T22:29:21Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cleaner Chemical Engineering |
| spelling | doaj.art-140889dd9ab4466e87cdbf39ffb1dd0d2022-12-22T02:26:59ZengElsevierCleaner Chemical Engineering2772-78232022-03-011100005Ecotoxicological assessment of amoxicillin trihydrate: Stability, solubility, and acute toxicity for Oreochromis niloticus, Lemna minor, and Daphnia magnaAlessandra Cristina de Moraes0Eduardo Adilson Orlando1Ed Johnny da Rosa Prado2Ana Carla Coleone de Carvalho3Joaquim Gonçalves Machado-Neto4Ana Valéria Colnaghi Simionato5Marcos Nogueira Eberlin6Marco Antonio de Andrade Belo7Veterinary College, Federal University of Rondônia (UNIR), Rolim de Moura-RO, BrazilFaculty of Food Engineering (FEA), State University of Campinas – UNICAMP, Campinas - SP, BrazilVeterinary College, Federal Institute of Rondônia, Jaru/RO, BrazilFaculty of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal/SP, BrazilFaculty of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal/SP, BrazilInstitute of Chemistry, State University of Campinas – UNICAMP, Campinas - SP, Brazil; National Institute of Science and Technology in Bioanalytics. Campinas-SP, BrazilMackMass Laboratory for Mass Spectrometry School of Engineering- PPGEMN Mackenzie Presbyterian University, São Paulo, SP, BrazilFaculty of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal/SP, Brazil; Laboratory of Animal Pharmacology and Toxicology, Brazil University (UB), Descalvado-SP, Brazil; Corresponding author at: Marco Antonio de Andrade Belo, 950 Hilário da Silva Passos Ave., Parque Universitário 13690-000, Descalvado, SP, BrazilAmong the different pharmaceuticals present in water as micro-contaminants, antibiotics are considered an important risk group for the aquatic ecosystem, since their increasing use in human and veterinary medicine could affect the diversity of microorganism communities. This study aims to classify the acute toxicity of amoxicillin trihydrate for organisms of different trophic levels of aquatic biological chains, represented by Oreochromis niloticus (fish), Lemna minor (macrophyte) and Daphnia magna (microcrustacean). For this purpose, amoxicillin trihydrate degradability in water as well as changes in physicochemical characteristics are focused herein. Initial tests were performed to validate the assay, including drug dissolution in M4 medium, drug degradation in various culture media, sensitivity of experimental organisms as well as preliminary drug intoxication test. Upon validation tests, 2.6 g L−1 amoxicillin was determined as the concentration to evaluate the toxicity factor. Static (48 h) and semi-static (168 h) assays were performed. Therefore, amoxicillin trihydrate did not have an acute toxic effect at the concentration of 2.6 g L−1 under the experimental conditions applied to the species Lemna minor, Daphnia magna and Oreochromis niloticus. demonstrating the very low acute toxicity to aquatic organisms at different trophic levels.http://www.sciencedirect.com/science/article/pii/S2772782322000055Degradation factorEnvironmentalFishMicrocrustaceanMacrophyteAminopenicillin |
| spellingShingle | Alessandra Cristina de Moraes Eduardo Adilson Orlando Ed Johnny da Rosa Prado Ana Carla Coleone de Carvalho Joaquim Gonçalves Machado-Neto Ana Valéria Colnaghi Simionato Marcos Nogueira Eberlin Marco Antonio de Andrade Belo Ecotoxicological assessment of amoxicillin trihydrate: Stability, solubility, and acute toxicity for Oreochromis niloticus, Lemna minor, and Daphnia magna Cleaner Chemical Engineering Degradation factor Environmental Fish Microcrustacean Macrophyte Aminopenicillin |
| title | Ecotoxicological assessment of amoxicillin trihydrate: Stability, solubility, and acute toxicity for Oreochromis niloticus, Lemna minor, and Daphnia magna |
| title_full | Ecotoxicological assessment of amoxicillin trihydrate: Stability, solubility, and acute toxicity for Oreochromis niloticus, Lemna minor, and Daphnia magna |
| title_fullStr | Ecotoxicological assessment of amoxicillin trihydrate: Stability, solubility, and acute toxicity for Oreochromis niloticus, Lemna minor, and Daphnia magna |
| title_full_unstemmed | Ecotoxicological assessment of amoxicillin trihydrate: Stability, solubility, and acute toxicity for Oreochromis niloticus, Lemna minor, and Daphnia magna |
| title_short | Ecotoxicological assessment of amoxicillin trihydrate: Stability, solubility, and acute toxicity for Oreochromis niloticus, Lemna minor, and Daphnia magna |
| title_sort | ecotoxicological assessment of amoxicillin trihydrate stability solubility and acute toxicity for oreochromis niloticus lemna minor and daphnia magna |
| topic | Degradation factor Environmental Fish Microcrustacean Macrophyte Aminopenicillin |
| url | http://www.sciencedirect.com/science/article/pii/S2772782322000055 |
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