Isolation of phytosterols of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) and modulation of antibiotic resistance by a possible membrane effect
Globally there are a larger number of strains of microorganisms resistant to multiple drugs mainly due to misuse and indiscriminate, resulting in increased morbidity, costs inherent benefits of health care, as well as mortality rates for infections. As a result of this a large number of researches h...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-11-01
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| Series: | Arabian Journal of Chemistry |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535214002263 |
| _version_ | 1818260275678150656 |
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| author | Gláucia M.M. Guedes Rosimeire S. Albuquerque Rafela S. Soares-Maciel Maria A. Freitas Viviane A. Silva Edeltrudes O. Lima Micheline A. Lima Emidio V.L. Cunha Henrique D.M. Coutinho |
| author_facet | Gláucia M.M. Guedes Rosimeire S. Albuquerque Rafela S. Soares-Maciel Maria A. Freitas Viviane A. Silva Edeltrudes O. Lima Micheline A. Lima Emidio V.L. Cunha Henrique D.M. Coutinho |
| author_sort | Gláucia M.M. Guedes |
| collection | DOAJ |
| description | Globally there are a larger number of strains of microorganisms resistant to multiple drugs mainly due to misuse and indiscriminate, resulting in increased morbidity, costs inherent benefits of health care, as well as mortality rates for infections. As a result of this a large number of researches have been conducted emphasizing the antimicrobial properties of plant products. In this study, the ethanol extract and hexane fraction of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) have been used to evaluate the antibacterial and antifungal activity and for modulating the resistance of antimicrobials against bacterial strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans and fungal strains of Candida krusei, Candida tropicalis. The antibacterial and modulatory activity was determined by microdilution. Inhibition of the growth of bacteria and fungi tested extract was ⩾1024. The activity was enhanced when aminoglycosides were associated with sub-inhibitory concentrations of the ethanol extract and hexane fraction of Dalbergia ecastophyllum. Therefore, it is suggested that the ethanol extract and hexane fraction of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) can be used as a source of natural products with a view to changing the resistance of these microorganisms to antimicrobials. Keywords: Microbial resistance, Dalbergia ecastophyllum, Antibacterial activity, Antifungal activity, Modulation |
| first_indexed | 2024-12-12T18:28:45Z |
| format | Article |
| id | doaj.art-1408a1cd53f847b1abc739eb690dc295 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-12T18:28:45Z |
| publishDate | 2019-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-1408a1cd53f847b1abc739eb690dc2952022-12-22T00:15:58ZengElsevierArabian Journal of Chemistry1878-53522019-11-0112715761580Isolation of phytosterols of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) and modulation of antibiotic resistance by a possible membrane effectGláucia M.M. Guedes0Rosimeire S. Albuquerque1Rafela S. Soares-Maciel2Maria A. Freitas3Viviane A. Silva4Edeltrudes O. Lima5Micheline A. Lima6Emidio V.L. Cunha7Henrique D.M. Coutinho8Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato (CE), BrazilLaboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato (CE), BrazilLaboratório de Tecnologias Farmacêuticas, Universidade Federal da Paraíba, João Pessoa (PB), BrazilLaboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato (CE), BrazilLaboratório de Tecnologias Farmacêuticas, Universidade Federal da Paraíba, João Pessoa (PB), BrazilLaboratório de Tecnologias Farmacêuticas, Universidade Federal da Paraíba, João Pessoa (PB), BrazilLaboratório de Tecnologias Farmacêuticas, Universidade Federal da Paraíba, João Pessoa (PB), BrazilLaboratório de Tecnologias Farmacêuticas, Universidade Federal da Paraíba, João Pessoa (PB), BrazilLaboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato (CE), Brazil; Corresponding author at: Departamento de Química Biológica, Universidade Regional do Cariri – URCA, Rua Cel. Antonio Luis 1161, Pimenta, 63105-000 Crato-CE, Brazil. Tel.: +55 (88) 31021212; fax: +55 (88) 31021291.Globally there are a larger number of strains of microorganisms resistant to multiple drugs mainly due to misuse and indiscriminate, resulting in increased morbidity, costs inherent benefits of health care, as well as mortality rates for infections. As a result of this a large number of researches have been conducted emphasizing the antimicrobial properties of plant products. In this study, the ethanol extract and hexane fraction of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) have been used to evaluate the antibacterial and antifungal activity and for modulating the resistance of antimicrobials against bacterial strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans and fungal strains of Candida krusei, Candida tropicalis. The antibacterial and modulatory activity was determined by microdilution. Inhibition of the growth of bacteria and fungi tested extract was ⩾1024. The activity was enhanced when aminoglycosides were associated with sub-inhibitory concentrations of the ethanol extract and hexane fraction of Dalbergia ecastophyllum. Therefore, it is suggested that the ethanol extract and hexane fraction of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) can be used as a source of natural products with a view to changing the resistance of these microorganisms to antimicrobials. Keywords: Microbial resistance, Dalbergia ecastophyllum, Antibacterial activity, Antifungal activity, Modulationhttp://www.sciencedirect.com/science/article/pii/S1878535214002263 |
| spellingShingle | Gláucia M.M. Guedes Rosimeire S. Albuquerque Rafela S. Soares-Maciel Maria A. Freitas Viviane A. Silva Edeltrudes O. Lima Micheline A. Lima Emidio V.L. Cunha Henrique D.M. Coutinho Isolation of phytosterols of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) and modulation of antibiotic resistance by a possible membrane effect Arabian Journal of Chemistry |
| title | Isolation of phytosterols of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) and modulation of antibiotic resistance by a possible membrane effect |
| title_full | Isolation of phytosterols of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) and modulation of antibiotic resistance by a possible membrane effect |
| title_fullStr | Isolation of phytosterols of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) and modulation of antibiotic resistance by a possible membrane effect |
| title_full_unstemmed | Isolation of phytosterols of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) and modulation of antibiotic resistance by a possible membrane effect |
| title_short | Isolation of phytosterols of Dalbergia ecastophyllum (L.) Taub. (Leguminosae) and modulation of antibiotic resistance by a possible membrane effect |
| title_sort | isolation of phytosterols of dalbergia ecastophyllum l taub leguminosae and modulation of antibiotic resistance by a possible membrane effect |
| url | http://www.sciencedirect.com/science/article/pii/S1878535214002263 |
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