Successful treatment of schizophrenia with melperone augmentation in a patient with phenotypic CYP2D6 ultrarapid metabolization: a case report
<p>Abstract</p> <p>Introduction</p> <p>There are limited treatment options for people with schizophrenia with cytochrome P450 2D6 ultrarapid metabolizer status who do not respond to amisulpride.</p> <p>Furthermore, the literature does not provide evidence-ba...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-02-01
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| Series: | Journal of Medical Case Reports |
| Online Access: | http://www.jmedicalcasereports.com/content/6/1/49 |
| _version_ | 1818208942255243264 |
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| author | Gahr Maximilian Gastl Regina Kölle Markus A Schönfeldt-Lecuona Carlos Freudenmann Roland W |
| author_facet | Gahr Maximilian Gastl Regina Kölle Markus A Schönfeldt-Lecuona Carlos Freudenmann Roland W |
| author_sort | Gahr Maximilian |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Introduction</p> <p>There are limited treatment options for people with schizophrenia with cytochrome P450 2D6 ultrarapid metabolizer status who do not respond to amisulpride.</p> <p>Furthermore, the literature does not provide evidence-based guidelines for this particular constellation.</p> <p>Case presentation</p> <p>We report the case of a 50-year-old Caucasian female patient with schizophrenia and cytochrome P450 2D6 ultrarapid metabolizer status who experienced an insufficient antipsychotic effect with amisulpride. She was successfully treated with melperone-augmented haloperidol.</p> <p>Conclusion</p> <p>This report yields melperone-augmented haloperidol as a possible pharmacological strategy in the described situation. In addition, our observations support the available evidence for the potential of melperone to act as an inhibitor of cytochrome P450 2D6.</p> |
| first_indexed | 2024-12-12T04:52:50Z |
| format | Article |
| id | doaj.art-14095c0d22b248919082dd008d7aa7ca |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-12T04:52:50Z |
| publishDate | 2012-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-14095c0d22b248919082dd008d7aa7ca2022-12-22T00:37:25ZengBMCJournal of Medical Case Reports1752-19472012-02-01614910.1186/1752-1947-6-49Successful treatment of schizophrenia with melperone augmentation in a patient with phenotypic CYP2D6 ultrarapid metabolization: a case reportGahr MaximilianGastl ReginaKölle Markus ASchönfeldt-Lecuona CarlosFreudenmann Roland W<p>Abstract</p> <p>Introduction</p> <p>There are limited treatment options for people with schizophrenia with cytochrome P450 2D6 ultrarapid metabolizer status who do not respond to amisulpride.</p> <p>Furthermore, the literature does not provide evidence-based guidelines for this particular constellation.</p> <p>Case presentation</p> <p>We report the case of a 50-year-old Caucasian female patient with schizophrenia and cytochrome P450 2D6 ultrarapid metabolizer status who experienced an insufficient antipsychotic effect with amisulpride. She was successfully treated with melperone-augmented haloperidol.</p> <p>Conclusion</p> <p>This report yields melperone-augmented haloperidol as a possible pharmacological strategy in the described situation. In addition, our observations support the available evidence for the potential of melperone to act as an inhibitor of cytochrome P450 2D6.</p>http://www.jmedicalcasereports.com/content/6/1/49 |
| spellingShingle | Gahr Maximilian Gastl Regina Kölle Markus A Schönfeldt-Lecuona Carlos Freudenmann Roland W Successful treatment of schizophrenia with melperone augmentation in a patient with phenotypic CYP2D6 ultrarapid metabolization: a case report Journal of Medical Case Reports |
| title | Successful treatment of schizophrenia with melperone augmentation in a patient with phenotypic CYP2D6 ultrarapid metabolization: a case report |
| title_full | Successful treatment of schizophrenia with melperone augmentation in a patient with phenotypic CYP2D6 ultrarapid metabolization: a case report |
| title_fullStr | Successful treatment of schizophrenia with melperone augmentation in a patient with phenotypic CYP2D6 ultrarapid metabolization: a case report |
| title_full_unstemmed | Successful treatment of schizophrenia with melperone augmentation in a patient with phenotypic CYP2D6 ultrarapid metabolization: a case report |
| title_short | Successful treatment of schizophrenia with melperone augmentation in a patient with phenotypic CYP2D6 ultrarapid metabolization: a case report |
| title_sort | successful treatment of schizophrenia with melperone augmentation in a patient with phenotypic cyp2d6 ultrarapid metabolization a case report |
| url | http://www.jmedicalcasereports.com/content/6/1/49 |
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