Polymorphic markers of GNB3 (C825T), AGTR1 (A1166C) and ACE (A2350G and I/D) genes in patients with arterial hypertension combined with diabetes mellitus type 2
Aim. To elicit correlations of polymorphic markers of GNB3 (C825T), AGTR1 (АП66С), ACE (A2350G and I/D) genes with arterial pressure, left ventricular hypertrophy (LVH) and blood concentrations of proinflammatory cytokines in hypertensive patients with diabetes mellitus type 2 (DM2). Material and Me...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2004-06-01
|
| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/29821 |
| _version_ | 1819263023436529664 |
|---|---|
| author | R S Karpov K V Puzyrev О A Koshelskaya O A Makeeva T E Suslova E V Efimova A Yu Falkovskaya A V Atroshenkov |
| author_facet | R S Karpov K V Puzyrev О A Koshelskaya O A Makeeva T E Suslova E V Efimova A Yu Falkovskaya A V Atroshenkov |
| author_sort | R S Karpov |
| collection | DOAJ |
| description | Aim. To elicit correlations of polymorphic markers of GNB3 (C825T), AGTR1 (АП66С), ACE (A2350G and I/D) genes with arterial pressure, left ventricular hypertrophy (LVH) and blood concentrations of proinflammatory cytokines in hypertensive patients with diabetes mellitus type 2 (DM2). Material and Methods. Clinical parameters (24-h arterial pressure profile, echocardiographic findings, immunoenzymes level) were studied in 89 hypertensive patients with DM2. These patients had different genotypes by the studied allele variants of the genes determined by polymerase chain reaction. Results. Polymorphism ofA1166Cgene of type 1 vascular receptor of angiotensin II (AGTR1) contributes to formation of arterial hypertension (AH) signs diversity in DM2 patients. GNB3, a gene C825T polymorphic marker, showed a correlation with diastolic arterial pressure but this variant of the gene locus is not associated with LVH. However, G-allele of ACE gene contributes much to appearance of this pathological sign. Mean values oflL-lfi and TNF-a as well as the presence of LVH depended on genotypes by ACE gene (polymorphism I/D).
Conclusion. Polymorphic markers of ACE and GNB3 candidate genes influence clinical diversity of pathological signs in DM2 patients through modification of AH and LVH severity and the level of proinflammatory cytokines. |
| first_indexed | 2024-12-23T20:07:00Z |
| format | Article |
| id | doaj.art-1409b0fead3b421d83d96aa302d33a71 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-23T20:07:00Z |
| publishDate | 2004-06-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-1409b0fead3b421d83d96aa302d33a712022-12-21T17:32:54Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422004-06-01796303526849Polymorphic markers of GNB3 (C825T), AGTR1 (A1166C) and ACE (A2350G and I/D) genes in patients with arterial hypertension combined with diabetes mellitus type 2R S KarpovK V PuzyrevО A KoshelskayaO A MakeevaT E SuslovaE V EfimovaA Yu FalkovskayaA V AtroshenkovAim. To elicit correlations of polymorphic markers of GNB3 (C825T), AGTR1 (АП66С), ACE (A2350G and I/D) genes with arterial pressure, left ventricular hypertrophy (LVH) and blood concentrations of proinflammatory cytokines in hypertensive patients with diabetes mellitus type 2 (DM2). Material and Methods. Clinical parameters (24-h arterial pressure profile, echocardiographic findings, immunoenzymes level) were studied in 89 hypertensive patients with DM2. These patients had different genotypes by the studied allele variants of the genes determined by polymerase chain reaction. Results. Polymorphism ofA1166Cgene of type 1 vascular receptor of angiotensin II (AGTR1) contributes to formation of arterial hypertension (AH) signs diversity in DM2 patients. GNB3, a gene C825T polymorphic marker, showed a correlation with diastolic arterial pressure but this variant of the gene locus is not associated with LVH. However, G-allele of ACE gene contributes much to appearance of this pathological sign. Mean values oflL-lfi and TNF-a as well as the presence of LVH depended on genotypes by ACE gene (polymorphism I/D). Conclusion. Polymorphic markers of ACE and GNB3 candidate genes influence clinical diversity of pathological signs in DM2 patients through modification of AH and LVH severity and the level of proinflammatory cytokines.https://ter-arkhiv.ru/0040-3660/article/view/29821arterial hypertensiondiabetes mellitus type 2polymorphism of candidate genes |
| spellingShingle | R S Karpov K V Puzyrev О A Koshelskaya O A Makeeva T E Suslova E V Efimova A Yu Falkovskaya A V Atroshenkov Polymorphic markers of GNB3 (C825T), AGTR1 (A1166C) and ACE (A2350G and I/D) genes in patients with arterial hypertension combined with diabetes mellitus type 2 Терапевтический архив arterial hypertension diabetes mellitus type 2 polymorphism of candidate genes |
| title | Polymorphic markers of GNB3 (C825T), AGTR1 (A1166C) and ACE (A2350G and I/D) genes in patients with arterial hypertension combined with diabetes mellitus type 2 |
| title_full | Polymorphic markers of GNB3 (C825T), AGTR1 (A1166C) and ACE (A2350G and I/D) genes in patients with arterial hypertension combined with diabetes mellitus type 2 |
| title_fullStr | Polymorphic markers of GNB3 (C825T), AGTR1 (A1166C) and ACE (A2350G and I/D) genes in patients with arterial hypertension combined with diabetes mellitus type 2 |
| title_full_unstemmed | Polymorphic markers of GNB3 (C825T), AGTR1 (A1166C) and ACE (A2350G and I/D) genes in patients with arterial hypertension combined with diabetes mellitus type 2 |
| title_short | Polymorphic markers of GNB3 (C825T), AGTR1 (A1166C) and ACE (A2350G and I/D) genes in patients with arterial hypertension combined with diabetes mellitus type 2 |
| title_sort | polymorphic markers of gnb3 c825t agtr1 a1166c and ace a2350g and i d genes in patients with arterial hypertension combined with diabetes mellitus type 2 |
| topic | arterial hypertension diabetes mellitus type 2 polymorphism of candidate genes |
| url | https://ter-arkhiv.ru/0040-3660/article/view/29821 |
| work_keys_str_mv | AT rskarpov polymorphicmarkersofgnb3c825tagtr1a1166candacea2350gandidgenesinpatientswitharterialhypertensioncombinedwithdiabetesmellitustype2 AT kvpuzyrev polymorphicmarkersofgnb3c825tagtr1a1166candacea2350gandidgenesinpatientswitharterialhypertensioncombinedwithdiabetesmellitustype2 AT oakoshelskaya polymorphicmarkersofgnb3c825tagtr1a1166candacea2350gandidgenesinpatientswitharterialhypertensioncombinedwithdiabetesmellitustype2 AT oamakeeva polymorphicmarkersofgnb3c825tagtr1a1166candacea2350gandidgenesinpatientswitharterialhypertensioncombinedwithdiabetesmellitustype2 AT tesuslova polymorphicmarkersofgnb3c825tagtr1a1166candacea2350gandidgenesinpatientswitharterialhypertensioncombinedwithdiabetesmellitustype2 AT evefimova polymorphicmarkersofgnb3c825tagtr1a1166candacea2350gandidgenesinpatientswitharterialhypertensioncombinedwithdiabetesmellitustype2 AT ayufalkovskaya polymorphicmarkersofgnb3c825tagtr1a1166candacea2350gandidgenesinpatientswitharterialhypertensioncombinedwithdiabetesmellitustype2 AT avatroshenkov polymorphicmarkersofgnb3c825tagtr1a1166candacea2350gandidgenesinpatientswitharterialhypertensioncombinedwithdiabetesmellitustype2 |