Awareness for People With Alzheimer’s Disease: Profiles and Weekly Trajectories
Objective: To understand awareness and fluctuations of awareness in Alzheimer’s disease (AD), it is fruitful to consider the objects of awareness, e.g., cognitive functioning or recognition of the disease, as well as the mechanisms and modes of expression underlying awareness. With a holistic and di...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.781426/full |
| _version_ | 1798021274689077248 |
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| author | Amandine Mayelle Capucine Hazebrouck Mohamad El Haj Mohamad El Haj Mohamad El Haj Daniel C. Mograbi Daniel C. Mograbi Pascal Antoine |
| author_facet | Amandine Mayelle Capucine Hazebrouck Mohamad El Haj Mohamad El Haj Mohamad El Haj Daniel C. Mograbi Daniel C. Mograbi Pascal Antoine |
| author_sort | Amandine Mayelle |
| collection | DOAJ |
| description | Objective: To understand awareness and fluctuations of awareness in Alzheimer’s disease (AD), it is fruitful to consider the objects of awareness, e.g., cognitive functioning or recognition of the disease, as well as the mechanisms and modes of expression underlying awareness. With a holistic and discourse-centered approach, we aimed to identify different awareness profiles and test whether these profiles were stable or whether transitions from one profile to another occurred over short time intervals.Methods: Twenty-eight residents of nursing homes with a diagnosis of AD participated in four semistructured interviews at biweekly intervals. These interviews were cluster analyzed to determine profiles of awareness. A Markov chain was applied to model their fluctuation.Results: Five awareness profiles were observed that differed in terms of objects and underlying processes. Awareness proved to be quite stable for four of the five profiles. Interindividual variability in awareness was also observed through numerous different trajectories that were identified.Discussion: Self-awareness and disease awareness are characterized by profiles that vary subtly between individuals. Fluctuations in awareness underscore the need to employ assessment intervals that closely reflect daily life in institutions. |
| first_indexed | 2024-04-11T17:11:01Z |
| format | Article |
| id | doaj.art-140c26a40e4a416ebc9d74451b27611f |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T17:11:01Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-140c26a40e4a416ebc9d74451b27611f2022-12-22T04:12:54ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-01-011310.3389/fnagi.2021.781426781426Awareness for People With Alzheimer’s Disease: Profiles and Weekly TrajectoriesAmandine Mayelle0Capucine Hazebrouck1Mohamad El Haj2Mohamad El Haj3Mohamad El Haj4Daniel C. Mograbi5Daniel C. Mograbi6Pascal Antoine7Univ. Lille, CNRS, UMR 9193—SCALab—Sciences Cognitives et Sciences Affectives, Lille, FranceEtablissements Pour Personnes Âgées Dépendantes La Colombe, Roncq and L’Orée du Monde, Halluin, FranceNantes Université, Univ Angers, Laboratoire de Psychologie des Pays de la Loire (LPPL—EA 4638), Nantes, FranceUnité de Gériatrie, Centre Hospitalier de Tourcoing, Tourcoing, FranceInstitut Universitaire de France, Paris, FrancePontifical Catholic University, Rio de Janeiro, BrazilInstitute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United KingdomUniv. Lille, CNRS, UMR 9193—SCALab—Sciences Cognitives et Sciences Affectives, Lille, FranceObjective: To understand awareness and fluctuations of awareness in Alzheimer’s disease (AD), it is fruitful to consider the objects of awareness, e.g., cognitive functioning or recognition of the disease, as well as the mechanisms and modes of expression underlying awareness. With a holistic and discourse-centered approach, we aimed to identify different awareness profiles and test whether these profiles were stable or whether transitions from one profile to another occurred over short time intervals.Methods: Twenty-eight residents of nursing homes with a diagnosis of AD participated in four semistructured interviews at biweekly intervals. These interviews were cluster analyzed to determine profiles of awareness. A Markov chain was applied to model their fluctuation.Results: Five awareness profiles were observed that differed in terms of objects and underlying processes. Awareness proved to be quite stable for four of the five profiles. Interindividual variability in awareness was also observed through numerous different trajectories that were identified.Discussion: Self-awareness and disease awareness are characterized by profiles that vary subtly between individuals. Fluctuations in awareness underscore the need to employ assessment intervals that closely reflect daily life in institutions.https://www.frontiersin.org/articles/10.3389/fnagi.2021.781426/fullAlzheimer’s diseaseanosognosiaawarenesstemporal trajectoryprofiles |
| spellingShingle | Amandine Mayelle Capucine Hazebrouck Mohamad El Haj Mohamad El Haj Mohamad El Haj Daniel C. Mograbi Daniel C. Mograbi Pascal Antoine Awareness for People With Alzheimer’s Disease: Profiles and Weekly Trajectories Frontiers in Aging Neuroscience Alzheimer’s disease anosognosia awareness temporal trajectory profiles |
| title | Awareness for People With Alzheimer’s Disease: Profiles and Weekly Trajectories |
| title_full | Awareness for People With Alzheimer’s Disease: Profiles and Weekly Trajectories |
| title_fullStr | Awareness for People With Alzheimer’s Disease: Profiles and Weekly Trajectories |
| title_full_unstemmed | Awareness for People With Alzheimer’s Disease: Profiles and Weekly Trajectories |
| title_short | Awareness for People With Alzheimer’s Disease: Profiles and Weekly Trajectories |
| title_sort | awareness for people with alzheimer s disease profiles and weekly trajectories |
| topic | Alzheimer’s disease anosognosia awareness temporal trajectory profiles |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.781426/full |
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