Comparison of <sup>99m</sup>Tc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis
We compared the detection rate (DR) for sentinel lymph nodes (SLN<sub>S</sub>), the number of SLNs and the subjects with additional SLNs of single-photon emission computed tomography (SPECT/CT) and planar lymphoscintigraphy (PL) in patients with melanoma. Furthermore, we evaluated the im...
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MDPI AG
2020-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/6/1680 |
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| author | Natale Quartuccio Ludovico Maria Garau Annachiara Arnone Marco Pappalardo Domenico Rubello Gaspare Arnone Gianpiero Manca |
| author_facet | Natale Quartuccio Ludovico Maria Garau Annachiara Arnone Marco Pappalardo Domenico Rubello Gaspare Arnone Gianpiero Manca |
| author_sort | Natale Quartuccio |
| collection | DOAJ |
| description | We compared the detection rate (DR) for sentinel lymph nodes (SLN<sub>S</sub>), the number of SLNs and the subjects with additional SLNs of single-photon emission computed tomography (SPECT/CT) and planar lymphoscintigraphy (PL) in patients with melanoma. Furthermore, we evaluated the impact of SPECT/CT on surgical plans. Articles containing head-to-head comparisons between SPECT/CT and PL were searched in Pubmed/MEDLINE and Scopus. The literature search was updated until December 31st, 2019. DR was calculated on a per-patient-based analysis; the studies were pooled by their odds ratios (ORs) with a random effects model to assess the significance of difference (<i>p</i> < 0.05). The number of additional SLNs (calculated as the relative risk) and pooled proportion of patients with additional SLNs were investigated. The pooled ratio of surgical procedures influenced by the SPECT/CT findings was calculated. Seventeen studies with 1438 patients were eligible for the calculation of DR of SPECT/CT and PL. The average DR was 98.28% (95% confidence interval (95% CI): 97.94–99.19%) for the SPECT/CT and 95.53% (95% CI: 92.55–97.77%) for the PL; OR of 2.31 (95% CI: 1.66–4.18, <i>p</i> < 0.001) in favor of the SPECT/CT. There was a relative risk of a higher number of SLNs (1.13) for the SPECT/CT and 17.87% of patients with additional SLNs were detected by SPECT/CT. The average impact of SPECT/CT on surgery resulted in 37.43% of cases. This meta-analysis favored SPECT/CT over PL for the identification of SLNs in patients with melanoma due to a higher DR, reproducibility, number of SLNs depicted, proportion of patients with additional SLNs and the impact on the surgical plan. However, PL remains a good option due to the high values of the DR for SLNs. |
| first_indexed | 2024-03-10T19:25:38Z |
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| id | doaj.art-140e15729c9b457a8f4c2e85664fdfe8 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T19:25:38Z |
| publishDate | 2020-06-01 |
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| spelling | doaj.art-140e15729c9b457a8f4c2e85664fdfe82023-11-20T02:32:52ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0196168010.3390/jcm9061680Comparison of <sup>99m</sup>Tc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-AnalysisNatale Quartuccio0Ludovico Maria Garau1Annachiara Arnone2Marco Pappalardo3Domenico Rubello4Gaspare Arnone5Gianpiero Manca6Nuclear Medicine Unit, A.R.N.A.S. Ospedali Civico, Di Cristina e Benfratelli, 90128 Palermo, ItalyRegional Center of Nuclear Medicine, Hospital University of Pisa, 56126 Pisa, ItalyNuclear Medicine Unit, A.R.N.A.S. Ospedali Civico, Di Cristina e Benfratelli, 90128 Palermo, ItalyDivision of Plastic and Reconstructive Surgery, Department of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, ItalyNuclear Medicine Unit, Santa Maria della Misericordia Hospital, 35100 Rovigo, ItalyNuclear Medicine Unit, A.R.N.A.S. Ospedali Civico, Di Cristina e Benfratelli, 90128 Palermo, ItalyRegional Center of Nuclear Medicine, Hospital University of Pisa, 56126 Pisa, ItalyWe compared the detection rate (DR) for sentinel lymph nodes (SLN<sub>S</sub>), the number of SLNs and the subjects with additional SLNs of single-photon emission computed tomography (SPECT/CT) and planar lymphoscintigraphy (PL) in patients with melanoma. Furthermore, we evaluated the impact of SPECT/CT on surgical plans. Articles containing head-to-head comparisons between SPECT/CT and PL were searched in Pubmed/MEDLINE and Scopus. The literature search was updated until December 31st, 2019. DR was calculated on a per-patient-based analysis; the studies were pooled by their odds ratios (ORs) with a random effects model to assess the significance of difference (<i>p</i> < 0.05). The number of additional SLNs (calculated as the relative risk) and pooled proportion of patients with additional SLNs were investigated. The pooled ratio of surgical procedures influenced by the SPECT/CT findings was calculated. Seventeen studies with 1438 patients were eligible for the calculation of DR of SPECT/CT and PL. The average DR was 98.28% (95% confidence interval (95% CI): 97.94–99.19%) for the SPECT/CT and 95.53% (95% CI: 92.55–97.77%) for the PL; OR of 2.31 (95% CI: 1.66–4.18, <i>p</i> < 0.001) in favor of the SPECT/CT. There was a relative risk of a higher number of SLNs (1.13) for the SPECT/CT and 17.87% of patients with additional SLNs were detected by SPECT/CT. The average impact of SPECT/CT on surgery resulted in 37.43% of cases. This meta-analysis favored SPECT/CT over PL for the identification of SLNs in patients with melanoma due to a higher DR, reproducibility, number of SLNs depicted, proportion of patients with additional SLNs and the impact on the surgical plan. However, PL remains a good option due to the high values of the DR for SLNs.https://www.mdpi.com/2077-0383/9/6/1680sentinel lymph nodesingle photon emission/computed tomographyplanar lymphoscintigraphy<sup>99m</sup>Tc-labeled colloidsmelanomameta-analysis |
| spellingShingle | Natale Quartuccio Ludovico Maria Garau Annachiara Arnone Marco Pappalardo Domenico Rubello Gaspare Arnone Gianpiero Manca Comparison of <sup>99m</sup>Tc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis Journal of Clinical Medicine sentinel lymph node single photon emission/computed tomography planar lymphoscintigraphy <sup>99m</sup>Tc-labeled colloids melanoma meta-analysis |
| title | Comparison of <sup>99m</sup>Tc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis |
| title_full | Comparison of <sup>99m</sup>Tc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis |
| title_fullStr | Comparison of <sup>99m</sup>Tc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis |
| title_full_unstemmed | Comparison of <sup>99m</sup>Tc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis |
| title_short | Comparison of <sup>99m</sup>Tc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis |
| title_sort | comparison of sup 99m sup tc labeled colloid spect ct and planar lymphoscintigraphy in sentinel lymph node detection in patients with melanoma a meta analysis |
| topic | sentinel lymph node single photon emission/computed tomography planar lymphoscintigraphy <sup>99m</sup>Tc-labeled colloids melanoma meta-analysis |
| url | https://www.mdpi.com/2077-0383/9/6/1680 |
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