Glycogen synthase kinase 3 activity enhances liver inflammation in MASH

Glycogen synthase kinase 3 activity enhances liver inflammation in MASH

Background & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by excessive circulating toxic lipids, hepatic steatosis, and liver inflammation. Monocyte adhesion to liver sinusoidal endothelial cells (LSECs) and transendothelial migration (TEM) are crucial in th...

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Main Authors: Mireille Khoury, Qianqian Guo, Kunimaro Furuta, Cristina Correia, Chady Meroueh, Hyun Se Kim Lee, Khaled Warasnhe, Lucía Valenzuela-Pérez, Andrew P. Mazar, Iljung Kim, Yung-Kyun Noh, Heather Holmes, Michael F. Romero, Caroline R. Sussman, Kevin D. Pavelko, Shahidul Islam, Adebowale O. Bamidele, Petra Hirsova, Hu Li, Samar H. Ibrahim
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:JHEP Reports
Subjects:
Glycogen synthase kinase 3 (GSK3)
Non-alcoholic steatohepatitis (NASH)
Metabolic dysfunction associated steatohepatitis (MASH)
Liver sinusoidal endothelial cells (LSEC)
Myeloid cells
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555924000776

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http://www.sciencedirect.com/science/article/pii/S2589555924000776

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