Laminar mechanisms of saccadic suppression in primate visual cortex
Summary: Saccadic eye movements are known to cause saccadic suppression, a temporary reduction in visual sensitivity and visual cortical firing rates. While saccadic suppression has been well characterized at the level of perception and single neurons, relatively little is known about the visual cor...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723007313 |
| _version_ | 1827911971471622144 |
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| author | Sachira Denagamage Mitchell P. Morton Nyomi V. Hudson John H. Reynolds Monika P. Jadi Anirvan S. Nandy |
| author_facet | Sachira Denagamage Mitchell P. Morton Nyomi V. Hudson John H. Reynolds Monika P. Jadi Anirvan S. Nandy |
| author_sort | Sachira Denagamage |
| collection | DOAJ |
| description | Summary: Saccadic eye movements are known to cause saccadic suppression, a temporary reduction in visual sensitivity and visual cortical firing rates. While saccadic suppression has been well characterized at the level of perception and single neurons, relatively little is known about the visual cortical networks governing this phenomenon. Here we examine the effects of saccadic suppression on distinct neural subpopulations within visual area V4. We find subpopulation-specific differences in the magnitude and timing of peri-saccadic modulation. Input-layer neurons show changes in firing rate and inter-neuronal correlations prior to saccade onset, and putative inhibitory interneurons in the input layer elevate their firing rate during saccades. A computational model of this circuit recapitulates our empirical observations and demonstrates that an input-layer-targeting pathway can initiate saccadic suppression by enhancing local inhibitory activity. Collectively, our results provide a mechanistic understanding of how eye movement signaling interacts with cortical circuitry to enforce visual stability. |
| first_indexed | 2024-03-13T02:09:45Z |
| format | Article |
| id | doaj.art-14108e4ca7534e49b4360cfa66051ab9 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-13T02:09:45Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-14108e4ca7534e49b4360cfa66051ab92023-07-01T04:34:46ZengElsevierCell Reports2211-12472023-07-01427112720Laminar mechanisms of saccadic suppression in primate visual cortexSachira Denagamage0Mitchell P. Morton1Nyomi V. Hudson2John H. Reynolds3Monika P. Jadi4Anirvan S. Nandy5Department of Neuroscience, Yale University, New Haven, CT 06511, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06511, USADepartment of Neuroscience, Yale University, New Haven, CT 06511, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06511, USADepartment of Neuroscience, Yale University, New Haven, CT 06511, USASystems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA 92037, USADepartment of Neuroscience, Yale University, New Haven, CT 06511, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06511, USA; Department of Psychiatry, Yale University, New Haven, CT 06511, USA; Kavli Institute for Neuroscience, Yale University, New Haven, CT 06511, USA; Wu Tsai Institute, Yale University, New Haven, CT 06511, USA; Corresponding authorDepartment of Neuroscience, Yale University, New Haven, CT 06511, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06511, USA; Kavli Institute for Neuroscience, Yale University, New Haven, CT 06511, USA; Wu Tsai Institute, Yale University, New Haven, CT 06511, USA; Corresponding authorSummary: Saccadic eye movements are known to cause saccadic suppression, a temporary reduction in visual sensitivity and visual cortical firing rates. While saccadic suppression has been well characterized at the level of perception and single neurons, relatively little is known about the visual cortical networks governing this phenomenon. Here we examine the effects of saccadic suppression on distinct neural subpopulations within visual area V4. We find subpopulation-specific differences in the magnitude and timing of peri-saccadic modulation. Input-layer neurons show changes in firing rate and inter-neuronal correlations prior to saccade onset, and putative inhibitory interneurons in the input layer elevate their firing rate during saccades. A computational model of this circuit recapitulates our empirical observations and demonstrates that an input-layer-targeting pathway can initiate saccadic suppression by enhancing local inhibitory activity. Collectively, our results provide a mechanistic understanding of how eye movement signaling interacts with cortical circuitry to enforce visual stability.http://www.sciencedirect.com/science/article/pii/S2211124723007313CP: Neuroscience |
| spellingShingle | Sachira Denagamage Mitchell P. Morton Nyomi V. Hudson John H. Reynolds Monika P. Jadi Anirvan S. Nandy Laminar mechanisms of saccadic suppression in primate visual cortex Cell Reports CP: Neuroscience |
| title | Laminar mechanisms of saccadic suppression in primate visual cortex |
| title_full | Laminar mechanisms of saccadic suppression in primate visual cortex |
| title_fullStr | Laminar mechanisms of saccadic suppression in primate visual cortex |
| title_full_unstemmed | Laminar mechanisms of saccadic suppression in primate visual cortex |
| title_short | Laminar mechanisms of saccadic suppression in primate visual cortex |
| title_sort | laminar mechanisms of saccadic suppression in primate visual cortex |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723007313 |
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