Plasma-Ionized Magnesium in Hospitalized Horses with Gastrointestinal Disorders and Systemic Inflammatory Response Syndrome
Magnesium disorders in horses with gastrointestinal disorders or systemic inflammatory response syndrome (SIRS) are scarcely characterized. The purpose of the study was to explore the association of magnesium disorders with diagnosis, SIRS and mortality in horses admitted to a referral equine hospit...
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MDPI AG
2022-06-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/12/12/1479 |
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| author | Julia Sanmartí Lara Armengou Lucas Troya-Portillo José Ángel Robles-Guirado Anna Bassols José Ríos Eduard Jose-Cunilleras |
| author_facet | Julia Sanmartí Lara Armengou Lucas Troya-Portillo José Ángel Robles-Guirado Anna Bassols José Ríos Eduard Jose-Cunilleras |
| author_sort | Julia Sanmartí |
| collection | DOAJ |
| description | Magnesium disorders in horses with gastrointestinal disorders or systemic inflammatory response syndrome (SIRS) are scarcely characterized. The purpose of the study was to explore the association of magnesium disorders with diagnosis, SIRS and mortality in horses admitted to a referral equine hospital. In total, 75 sick horses were included in an observational prospective study and classified as: obstructive (<i>n</i> = 17), inflammatory (<i>n</i> = 10) and ischemic gastrointestinal disorders (<i>n</i> = 12), and other non-gastrointestinal systemic disorders (<i>n</i> = 36). All sick horses were also divided according to the presence (<i>n</i> = 26) or absence of SIRS, and survival to discharge from hospital (survivors (<i>n</i> = 61) and non-survivors (<i>n</i> = 14). In addition, 26 horses were included as controls. On admission, mean (iMg) (95% confidence interval (CI)) in the SIRS group (0.47 (0.43–0.50 mmol/L)) was within the normal range (0.4–0.6 mmol/L). The obstructive group had lower (iMg) compared to the control group (0.44 (0.38–0.51 mmol/L) vs. 0.56 (0.50–0.61 mmol/L); <i>p</i> = 0.001). In total, 8 out of 17 (47%) horses with obstructive lesions presented with hypomagnesemia compared to controls (4% (1/26)) (<i>p</i> = 0.001). In conclusion, hypomagnesemia was more prevalent on admission in horses in the obstructive group, and to a lesser extent, in the inflammatory and ischemic groups. In contrast to human ICU patients, the proportion of hospitalized horses with hypomagnesemia was not associated with mortality. |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T00:37:48Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-1410ea5757a84d4b9381bb71c5c299ef2023-11-23T15:13:47ZengMDPI AGAnimals2076-26152022-06-011212147910.3390/ani12121479Plasma-Ionized Magnesium in Hospitalized Horses with Gastrointestinal Disorders and Systemic Inflammatory Response SyndromeJulia Sanmartí0Lara Armengou1Lucas Troya-Portillo2José Ángel Robles-Guirado3Anna Bassols4José Ríos5Eduard Jose-Cunilleras6Servei de Medicina Interna Equina, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, SpainServei de Medicina Interna Equina, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, SpainServei de Medicina Interna Equina, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, SpainDepartament de Bioquímica i Biologia Molecular, Facultat de Veterinaria, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, SpainDepartament de Bioquímica i Biologia Molecular, Facultat de Veterinaria, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, SpainDepartment of Clinical Farmacology, Hospital Clinic, Medical Statistics Core Facility, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainServei de Medicina Interna Equina, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, SpainMagnesium disorders in horses with gastrointestinal disorders or systemic inflammatory response syndrome (SIRS) are scarcely characterized. The purpose of the study was to explore the association of magnesium disorders with diagnosis, SIRS and mortality in horses admitted to a referral equine hospital. In total, 75 sick horses were included in an observational prospective study and classified as: obstructive (<i>n</i> = 17), inflammatory (<i>n</i> = 10) and ischemic gastrointestinal disorders (<i>n</i> = 12), and other non-gastrointestinal systemic disorders (<i>n</i> = 36). All sick horses were also divided according to the presence (<i>n</i> = 26) or absence of SIRS, and survival to discharge from hospital (survivors (<i>n</i> = 61) and non-survivors (<i>n</i> = 14). In addition, 26 horses were included as controls. On admission, mean (iMg) (95% confidence interval (CI)) in the SIRS group (0.47 (0.43–0.50 mmol/L)) was within the normal range (0.4–0.6 mmol/L). The obstructive group had lower (iMg) compared to the control group (0.44 (0.38–0.51 mmol/L) vs. 0.56 (0.50–0.61 mmol/L); <i>p</i> = 0.001). In total, 8 out of 17 (47%) horses with obstructive lesions presented with hypomagnesemia compared to controls (4% (1/26)) (<i>p</i> = 0.001). In conclusion, hypomagnesemia was more prevalent on admission in horses in the obstructive group, and to a lesser extent, in the inflammatory and ischemic groups. In contrast to human ICU patients, the proportion of hospitalized horses with hypomagnesemia was not associated with mortality.https://www.mdpi.com/2076-2615/12/12/1479hypomagnesemiahypocalcemiagastrointestinal disorderselectrolytesequine |
| spellingShingle | Julia Sanmartí Lara Armengou Lucas Troya-Portillo José Ángel Robles-Guirado Anna Bassols José Ríos Eduard Jose-Cunilleras Plasma-Ionized Magnesium in Hospitalized Horses with Gastrointestinal Disorders and Systemic Inflammatory Response Syndrome Animals hypomagnesemia hypocalcemia gastrointestinal disorders electrolytes equine |
| title | Plasma-Ionized Magnesium in Hospitalized Horses with Gastrointestinal Disorders and Systemic Inflammatory Response Syndrome |
| title_full | Plasma-Ionized Magnesium in Hospitalized Horses with Gastrointestinal Disorders and Systemic Inflammatory Response Syndrome |
| title_fullStr | Plasma-Ionized Magnesium in Hospitalized Horses with Gastrointestinal Disorders and Systemic Inflammatory Response Syndrome |
| title_full_unstemmed | Plasma-Ionized Magnesium in Hospitalized Horses with Gastrointestinal Disorders and Systemic Inflammatory Response Syndrome |
| title_short | Plasma-Ionized Magnesium in Hospitalized Horses with Gastrointestinal Disorders and Systemic Inflammatory Response Syndrome |
| title_sort | plasma ionized magnesium in hospitalized horses with gastrointestinal disorders and systemic inflammatory response syndrome |
| topic | hypomagnesemia hypocalcemia gastrointestinal disorders electrolytes equine |
| url | https://www.mdpi.com/2076-2615/12/12/1479 |
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