mTOR Signaling Components in Tumor Mechanobiology
Mechanistic target of rapamycin (mTOR) is a central signaling hub that integrates networks of nutrient availability, cellular metabolism, and autophagy in eukaryotic cells. mTOR kinase, along with its upstream regulators and downstream substrates, is upregulated in most human malignancies. At the sa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/3/1825 |
| _version_ | 1797487152694558720 |
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| author | Antonios N. Gargalionis Kostas A. Papavassiliou Efthimia K. Basdra Athanasios G. Papavassiliou |
| author_facet | Antonios N. Gargalionis Kostas A. Papavassiliou Efthimia K. Basdra Athanasios G. Papavassiliou |
| author_sort | Antonios N. Gargalionis |
| collection | DOAJ |
| description | Mechanistic target of rapamycin (mTOR) is a central signaling hub that integrates networks of nutrient availability, cellular metabolism, and autophagy in eukaryotic cells. mTOR kinase, along with its upstream regulators and downstream substrates, is upregulated in most human malignancies. At the same time, mechanical forces from the tumor microenvironment and mechanotransduction promote cancer cells’ proliferation, motility, and invasion. mTOR signaling pathway has been recently found on the crossroads of mechanoresponsive-induced signaling cascades to regulate cell growth, invasion, and metastasis in cancer cells. In this review, we examine the emerging association of mTOR signaling components with certain protein tools of tumor mechanobiology. Thereby, we highlight novel mechanisms of mechanotransduction, which regulate tumor progression and invasion, as well as mechanisms related to the therapeutic efficacy of antitumor drugs. |
| first_indexed | 2024-03-09T23:43:30Z |
| format | Article |
| id | doaj.art-1416ea1b849f4311ae5ac92de093423d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:43:30Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1416ea1b849f4311ae5ac92de093423d2023-11-23T16:47:12ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01233182510.3390/ijms23031825mTOR Signaling Components in Tumor MechanobiologyAntonios N. Gargalionis0Kostas A. Papavassiliou1Efthimia K. Basdra2Athanasios G. Papavassiliou3Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceMechanistic target of rapamycin (mTOR) is a central signaling hub that integrates networks of nutrient availability, cellular metabolism, and autophagy in eukaryotic cells. mTOR kinase, along with its upstream regulators and downstream substrates, is upregulated in most human malignancies. At the same time, mechanical forces from the tumor microenvironment and mechanotransduction promote cancer cells’ proliferation, motility, and invasion. mTOR signaling pathway has been recently found on the crossroads of mechanoresponsive-induced signaling cascades to regulate cell growth, invasion, and metastasis in cancer cells. In this review, we examine the emerging association of mTOR signaling components with certain protein tools of tumor mechanobiology. Thereby, we highlight novel mechanisms of mechanotransduction, which regulate tumor progression and invasion, as well as mechanisms related to the therapeutic efficacy of antitumor drugs.https://www.mdpi.com/1422-0067/23/3/1825tumor mechanobiologymechanotransductionmTORAktPI3Kintegrin |
| spellingShingle | Antonios N. Gargalionis Kostas A. Papavassiliou Efthimia K. Basdra Athanasios G. Papavassiliou mTOR Signaling Components in Tumor Mechanobiology International Journal of Molecular Sciences tumor mechanobiology mechanotransduction mTOR Akt PI3K integrin |
| title | mTOR Signaling Components in Tumor Mechanobiology |
| title_full | mTOR Signaling Components in Tumor Mechanobiology |
| title_fullStr | mTOR Signaling Components in Tumor Mechanobiology |
| title_full_unstemmed | mTOR Signaling Components in Tumor Mechanobiology |
| title_short | mTOR Signaling Components in Tumor Mechanobiology |
| title_sort | mtor signaling components in tumor mechanobiology |
| topic | tumor mechanobiology mechanotransduction mTOR Akt PI3K integrin |
| url | https://www.mdpi.com/1422-0067/23/3/1825 |
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