Uncovering the Role of p38 Family Members in Adipose Tissue Physiology
The complex functions of adipose tissue have been a focus of research interest over the past twenty years. Adipose tissue is not only the main energy storage depot, but also one of the largest endocrine organs in the body and carries out crucial metabolic functions. Moreover, brown and beige adipose...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-12-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2020.572089/full |
| _version_ | 1818611702819717120 |
|---|---|
| author | Magdalena Leiva Nuria Matesanz Marta Pulgarín-Alfaro Ivana Nikolic Guadalupe Sabio |
| author_facet | Magdalena Leiva Nuria Matesanz Marta Pulgarín-Alfaro Ivana Nikolic Guadalupe Sabio |
| author_sort | Magdalena Leiva |
| collection | DOAJ |
| description | The complex functions of adipose tissue have been a focus of research interest over the past twenty years. Adipose tissue is not only the main energy storage depot, but also one of the largest endocrine organs in the body and carries out crucial metabolic functions. Moreover, brown and beige adipose depots are major sites of energy expenditure through the activation of adaptive, non-shivering thermogenesis. In recent years, numerous signaling molecules and pathways have emerged as critical regulators of adipose tissue, in both homeostasis and obesity-related disease. Among the best characterized are members of the p38 kinase family. The activity of these kinases has emerged as a key contributor to the biology of the white and brown adipose tissues, and their modulation could provide new therapeutic approaches against obesity. Here, we give an overview of the roles of the distinct p38 family members in adipose tissue, focusing on their actions in adipogenesis, thermogenic activity, and secretory function. |
| first_indexed | 2024-12-16T15:34:32Z |
| format | Article |
| id | doaj.art-1417201620b643f8ae29ad512577a6fc |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-16T15:34:32Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-1417201620b643f8ae29ad512577a6fc2022-12-21T22:26:14ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-12-011110.3389/fendo.2020.572089572089Uncovering the Role of p38 Family Members in Adipose Tissue PhysiologyMagdalena LeivaNuria MatesanzMarta Pulgarín-AlfaroIvana NikolicGuadalupe SabioThe complex functions of adipose tissue have been a focus of research interest over the past twenty years. Adipose tissue is not only the main energy storage depot, but also one of the largest endocrine organs in the body and carries out crucial metabolic functions. Moreover, brown and beige adipose depots are major sites of energy expenditure through the activation of adaptive, non-shivering thermogenesis. In recent years, numerous signaling molecules and pathways have emerged as critical regulators of adipose tissue, in both homeostasis and obesity-related disease. Among the best characterized are members of the p38 kinase family. The activity of these kinases has emerged as a key contributor to the biology of the white and brown adipose tissues, and their modulation could provide new therapeutic approaches against obesity. Here, we give an overview of the roles of the distinct p38 family members in adipose tissue, focusing on their actions in adipogenesis, thermogenic activity, and secretory function.https://www.frontiersin.org/articles/10.3389/fendo.2020.572089/fullsignalingkinaseAdiposeBrownP38p38 mitogen-activated protein kinase(s) |
| spellingShingle | Magdalena Leiva Nuria Matesanz Marta Pulgarín-Alfaro Ivana Nikolic Guadalupe Sabio Uncovering the Role of p38 Family Members in Adipose Tissue Physiology Frontiers in Endocrinology signaling kinase Adipose Brown P38 p38 mitogen-activated protein kinase(s) |
| title | Uncovering the Role of p38 Family Members in Adipose Tissue Physiology |
| title_full | Uncovering the Role of p38 Family Members in Adipose Tissue Physiology |
| title_fullStr | Uncovering the Role of p38 Family Members in Adipose Tissue Physiology |
| title_full_unstemmed | Uncovering the Role of p38 Family Members in Adipose Tissue Physiology |
| title_short | Uncovering the Role of p38 Family Members in Adipose Tissue Physiology |
| title_sort | uncovering the role of p38 family members in adipose tissue physiology |
| topic | signaling kinase Adipose Brown P38 p38 mitogen-activated protein kinase(s) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2020.572089/full |
| work_keys_str_mv | AT magdalenaleiva uncoveringtheroleofp38familymembersinadiposetissuephysiology AT nuriamatesanz uncoveringtheroleofp38familymembersinadiposetissuephysiology AT martapulgarinalfaro uncoveringtheroleofp38familymembersinadiposetissuephysiology AT ivananikolic uncoveringtheroleofp38familymembersinadiposetissuephysiology AT guadalupesabio uncoveringtheroleofp38familymembersinadiposetissuephysiology |