Inhibition of Cyclin D1 Expression in Human Glioblastoma Cells is Associated with Increased Temozolomide Chemosensitivity

Inhibition of Cyclin D1 Expression in Human Glioblastoma Cells is Associated with Increased Temozolomide Chemosensitivity

Background/Aims: Cyclin D1 (CCND1) is frequently overexpressed in malignant gliomas. We have previously shown ectopic overexpression of CCND1 in human malignant gliomas cell lines. Methods: Quantitative reverse transcriptase PCR (qRT-PCR) and Western Blot (WB) was performed to investigate the expres...

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Bibliographic Details
Main Authors: Danfeng Zhang, Dawei Dai, Mengxia Zhou, Zhenxing Li, Chunhui Wang, Yicheng Lu, Yiming Li, Junyu Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Glioblastoma
Chemoresistance
Temozolomide
CCND1
MDR1
Online Access:https://www.karger.com/Article/FullText/495920

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