Models of Aire-dependent gene regulation for thymic negative selection

Models of Aire-dependent gene regulation for thymic negative selection

Mutations in the Autoimmune Regulator (AIRE) gene lead to Autoimmune Polyendocrinopathy Syndrome type 1 (APS1), characterized by the development of multi-organ autoimmune damage. The mechanism by which defects in AIRE result in autoimmunity has been the subject of intense scrutiny. At the cellular l...

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Bibliographic Details
Main Authors: Dina eDanso-Abeam, Stephanie eHumblet-Baron, James eDooley, Adrian eListon
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-05-01
Series:Frontiers in Immunology
Subjects:
Autoimmunity
tolerance
transcription factor
AIRE
tissue restricted antigen
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00014/full

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