GRP94 Inhabits the Immortalized Porcine Hepatic Stellate Cells Apoptosis under Endoplasmic Reticulum Stress through Modulating the Expression of IGF-1 and Ubiquitin

GRP94 Inhabits the Immortalized Porcine Hepatic Stellate Cells Apoptosis under Endoplasmic Reticulum Stress through Modulating the Expression of IGF-1 and Ubiquitin

Endoplasmic reticulum stress (ERS) is closely related to the occurrence and progression of metabolic liver disease. The treatment targeting glucose-regulated protein 94 (GRP94) for liver disease has gotten much attention, but the specific effect of GRP94 on hepatocyte apoptosis is still unclear. So...

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Bibliographic Details
Main Authors: Xiaohong Wang, Hairui Xin, Chuang Zhang, Xianhong Gu, Yue Hao
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
endoplasmic reticulum stress
piglet liver
hepatic stellate cell
GRP94
IGF-1
ubiquitin
Online Access:https://www.mdpi.com/1422-0067/23/22/14059

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