Associations of Dietary Inflammatory Potential with Esophageal Precancerous Lesions and Esophageal Squamous-Cell Cancer: A Cross-Sectional Study
Chronic inflammation plays a central role in the progression from esophageal precancerous lesions (EPLs) to esophageal squamous-cell cancer (ESCC). However, few studies have investigated the relationship between the overall inflammatory potential of diets and EPLs and ESCC. We aimed to study the ass...
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MDPI AG
2023-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/18/4078 |
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| author | Jingwen Dong Min Gao Lin Li Xiaoyu Pan Sheng-Yin Chen Jun Li Stephanie A. Smith-Warner Xiaoguang Li Hui Wang Jiali Zheng |
| author_facet | Jingwen Dong Min Gao Lin Li Xiaoyu Pan Sheng-Yin Chen Jun Li Stephanie A. Smith-Warner Xiaoguang Li Hui Wang Jiali Zheng |
| author_sort | Jingwen Dong |
| collection | DOAJ |
| description | Chronic inflammation plays a central role in the progression from esophageal precancerous lesions (EPLs) to esophageal squamous-cell cancer (ESCC). However, few studies have investigated the relationship between the overall inflammatory potential of diets and EPLs and ESCC. We aimed to study the association between the Dietary Inflammatory Index (DII) and EPLs and ESCC. As part of the National Cohort of Esophageal Cancer (NCEC) in China, 3967 residents (1993 men and 1974 women) aged from 40 to 69 years living in Yanting County received free gastroscopy screenings from 2017 to 2019. Dietary intake during the past year was assessed at enrollment of the cohort before screening and DII scores were calculated based on 28 food parameters. EPLs (classified into mild, moderate, and severe dysplasia) and ESCC were histologically confirmed by biopsy. Multivariable logistic regression was used to examine the associations of DII scores with EPLs and ESCC. A total of 312 participants were diagnosed with EPLs (226 with mild dysplasia, 40 with moderate dysplasia, and 46 with severe dysplasia) and 72 were diagnosed with ESCC. A statistically significant positive association was observed between DII scores and overall EPLs (OR<sub>T3 vs. T1</sub> = 1.45, 95%CI = 1.01–2.09); the association was similar but not statistically significant for mild dysplasia (OR<sub>one-unit-increment</sub> = 1.11, 95%CI = 0.95–1.34) and for moderate and severe dysplasia combined (OR<sub>one-unit-increment</sub> = 1.15, 95%CI = 0.87–1.51). The association with ESCC was similar in magnitude but not significant, likely due to the small number of cases. In this cross-sectional study of a population in China at high risk of ESCC, DII scores were positively associated with odds of EPLs and ESCC. Consumption of anti-inflammatory foods may be beneficial to prevent EPLs and ESCC. |
| first_indexed | 2024-03-10T22:19:02Z |
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| id | doaj.art-141c18cbe76c4d798fd6abae209377c1 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T22:19:02Z |
| publishDate | 2023-09-01 |
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| spelling | doaj.art-141c18cbe76c4d798fd6abae209377c12023-11-19T12:20:04ZengMDPI AGNutrients2072-66432023-09-011518407810.3390/nu15184078Associations of Dietary Inflammatory Potential with Esophageal Precancerous Lesions and Esophageal Squamous-Cell Cancer: A Cross-Sectional StudyJingwen Dong0Min Gao1Lin Li2Xiaoyu Pan3Sheng-Yin Chen4Jun Li5Stephanie A. Smith-Warner6Xiaoguang Li7Hui Wang8Jiali Zheng9Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USASchool of Public Health, Capital Medical University, Beijing 100069, ChinaCancer Prevention and Treatment Office, Yanting Cancer Hospital, Mianyang 621600, ChinaDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USADepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USACancer Prevention and Treatment Office, Yanting Cancer Hospital, Mianyang 621600, ChinaDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USADepartment of Food Safety and Toxicology, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Food Safety and Toxicology, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Epidemiology and Biostatistics, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaChronic inflammation plays a central role in the progression from esophageal precancerous lesions (EPLs) to esophageal squamous-cell cancer (ESCC). However, few studies have investigated the relationship between the overall inflammatory potential of diets and EPLs and ESCC. We aimed to study the association between the Dietary Inflammatory Index (DII) and EPLs and ESCC. As part of the National Cohort of Esophageal Cancer (NCEC) in China, 3967 residents (1993 men and 1974 women) aged from 40 to 69 years living in Yanting County received free gastroscopy screenings from 2017 to 2019. Dietary intake during the past year was assessed at enrollment of the cohort before screening and DII scores were calculated based on 28 food parameters. EPLs (classified into mild, moderate, and severe dysplasia) and ESCC were histologically confirmed by biopsy. Multivariable logistic regression was used to examine the associations of DII scores with EPLs and ESCC. A total of 312 participants were diagnosed with EPLs (226 with mild dysplasia, 40 with moderate dysplasia, and 46 with severe dysplasia) and 72 were diagnosed with ESCC. A statistically significant positive association was observed between DII scores and overall EPLs (OR<sub>T3 vs. T1</sub> = 1.45, 95%CI = 1.01–2.09); the association was similar but not statistically significant for mild dysplasia (OR<sub>one-unit-increment</sub> = 1.11, 95%CI = 0.95–1.34) and for moderate and severe dysplasia combined (OR<sub>one-unit-increment</sub> = 1.15, 95%CI = 0.87–1.51). The association with ESCC was similar in magnitude but not significant, likely due to the small number of cases. In this cross-sectional study of a population in China at high risk of ESCC, DII scores were positively associated with odds of EPLs and ESCC. Consumption of anti-inflammatory foods may be beneficial to prevent EPLs and ESCC.https://www.mdpi.com/2072-6643/15/18/4078dietary inflammatory indexesophageal precancerous lesionsesophageal squamous-cell cancerdysplasiacross-sectional studychronic inflammation |
| spellingShingle | Jingwen Dong Min Gao Lin Li Xiaoyu Pan Sheng-Yin Chen Jun Li Stephanie A. Smith-Warner Xiaoguang Li Hui Wang Jiali Zheng Associations of Dietary Inflammatory Potential with Esophageal Precancerous Lesions and Esophageal Squamous-Cell Cancer: A Cross-Sectional Study Nutrients dietary inflammatory index esophageal precancerous lesions esophageal squamous-cell cancer dysplasia cross-sectional study chronic inflammation |
| title | Associations of Dietary Inflammatory Potential with Esophageal Precancerous Lesions and Esophageal Squamous-Cell Cancer: A Cross-Sectional Study |
| title_full | Associations of Dietary Inflammatory Potential with Esophageal Precancerous Lesions and Esophageal Squamous-Cell Cancer: A Cross-Sectional Study |
| title_fullStr | Associations of Dietary Inflammatory Potential with Esophageal Precancerous Lesions and Esophageal Squamous-Cell Cancer: A Cross-Sectional Study |
| title_full_unstemmed | Associations of Dietary Inflammatory Potential with Esophageal Precancerous Lesions and Esophageal Squamous-Cell Cancer: A Cross-Sectional Study |
| title_short | Associations of Dietary Inflammatory Potential with Esophageal Precancerous Lesions and Esophageal Squamous-Cell Cancer: A Cross-Sectional Study |
| title_sort | associations of dietary inflammatory potential with esophageal precancerous lesions and esophageal squamous cell cancer a cross sectional study |
| topic | dietary inflammatory index esophageal precancerous lesions esophageal squamous-cell cancer dysplasia cross-sectional study chronic inflammation |
| url | https://www.mdpi.com/2072-6643/15/18/4078 |
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