Characterization of Aberrations in DNA Damage Repair Pathways in Gastrointestinal Stromal Tumors: The Clinicopathologic Relevance of γH2AX and 53BP1 in Correlation with Heterozygous Deletions of <i>CHEK2</i>, <i>BRCA2</i>, and <i>RB1</i>

Characterization of Aberrations in DNA Damage Repair Pathways in Gastrointestinal Stromal Tumors: The Clinicopathologic Relevance of γH2AX and 53BP1 in Correlation with Heterozygous Deletions of <i>CHEK2</i>, <i>BRCA2</i>, and <i>RB1</i>

Genetic aberrations involving DNA damage repair (DDR) remain underexplored in gastrointestinal stromal tumors (GISTs). We characterized DDR abnormalities using targeted next-generation sequencing and multiplex ligation-dependent probe amplification, and performed immunofluorescence (IF) and immunohi...

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Bibliographic Details
Main Authors: Ting-Ting Liu, Chien-Feng Li, Kien-Thiam Tan, Yi-Hua Jan, Pei-Hang Lee, Chih-Hao Huang, Shih-Chen Yu, Cheng-Feng Tsao, Jui-Chu Wang, Hsuan-Ying Huang
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
gastrointestinal stromal tumor
DNA damage repair
γ-H2AX
53BP1
<i>BRCA2</i>
<i>CHEK2</i>
Online Access:https://www.mdpi.com/2072-6694/14/7/1787

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