Drug Delivery Strategies for Enhancing the Therapeutic Efficacy of Toxin-Derived Anti-Diabetic Peptides
Toxin peptides derived from the skin secretions of amphibians possess unique hypoglycemic activities. Many of these peptides share cationic and amphipathic structural similarities and appear to possess cell-penetrating abilities. The mechanism of their insulinotropic action is yet not elucidated, bu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/12/5/313 |
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| author | Reeju Amatya Taehoon Park Seungmi Hwang JaeWook Yang Yoonjin Lee Heesun Cheong Cheol Moon Hyun Duck Kwak Kyoung Ah Min Meong Cheol Shin |
| author_facet | Reeju Amatya Taehoon Park Seungmi Hwang JaeWook Yang Yoonjin Lee Heesun Cheong Cheol Moon Hyun Duck Kwak Kyoung Ah Min Meong Cheol Shin |
| author_sort | Reeju Amatya |
| collection | DOAJ |
| description | Toxin peptides derived from the skin secretions of amphibians possess unique hypoglycemic activities. Many of these peptides share cationic and amphipathic structural similarities and appear to possess cell-penetrating abilities. The mechanism of their insulinotropic action is yet not elucidated, but they have shown great potential in regulating the blood glucose levels in animal models. Therefore, they have emerged as potential drug candidates as therapeutics for type 2 diabetes. Despite their anti-diabetic activity, there remain pharmaceutical challenges to be addressed for their clinical applications. Here, we present an overview of recent studies related to the toxin-derived anti-diabetic peptides derived from the skin secretions of amphibians. In the latter part, we introduce the bottleneck challenges for their delivery in vivo and general drug delivery strategies that may be applicable to extend their blood circulation time. We focus our research on the strategies that have been successfully applied to improve the plasma half-life of exendin-4, a clinically available toxin-derived anti-diabetic peptide drug. |
| first_indexed | 2024-03-10T19:55:09Z |
| format | Article |
| id | doaj.art-141e8f99b20146a0bb5bf5cbb8300263 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T19:55:09Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-141e8f99b20146a0bb5bf5cbb83002632023-11-19T23:59:15ZengMDPI AGToxins2072-66512020-05-0112531310.3390/toxins12050313Drug Delivery Strategies for Enhancing the Therapeutic Efficacy of Toxin-Derived Anti-Diabetic PeptidesReeju Amatya0Taehoon Park1Seungmi Hwang2JaeWook Yang3Yoonjin Lee4Heesun Cheong5Cheol Moon6Hyun Duck Kwak7Kyoung Ah Min8Meong Cheol Shin9College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, 501 Jinju Daero, Jinju, Gyeongnam 52828, KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, 501 Jinju Daero, Jinju, Gyeongnam 52828, KoreaCollege of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, 197 Injero, Gimhae, Gyeongnam 50834, KoreaDepartment of Ophthalmology, Busan Paik Hospital, Inje University College of Medicine, 75 Bokjiro, Busanjin-gu, Busan 47392, KoreaT2B Infrastructure Center for Ocular Disease, Inje University Busan Paik Hospital, 81 Jinsaro 83 Beon-gil, Busanjin-gu, Busan 47397, KoreaDivision of Cancer Biology, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi-do 10408, KoreaCollege of Pharmacy, Sunchon National University, 255 Jungang-ro, Suncheon, Jeonnam 57922, KoreaDepartment of Ophthalmology, Busan Paik Hospital, Inje University College of Medicine, 75 Bokjiro, Busanjin-gu, Busan 47392, KoreaCollege of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, 197 Injero, Gimhae, Gyeongnam 50834, KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, 501 Jinju Daero, Jinju, Gyeongnam 52828, KoreaToxin peptides derived from the skin secretions of amphibians possess unique hypoglycemic activities. Many of these peptides share cationic and amphipathic structural similarities and appear to possess cell-penetrating abilities. The mechanism of their insulinotropic action is yet not elucidated, but they have shown great potential in regulating the blood glucose levels in animal models. Therefore, they have emerged as potential drug candidates as therapeutics for type 2 diabetes. Despite their anti-diabetic activity, there remain pharmaceutical challenges to be addressed for their clinical applications. Here, we present an overview of recent studies related to the toxin-derived anti-diabetic peptides derived from the skin secretions of amphibians. In the latter part, we introduce the bottleneck challenges for their delivery in vivo and general drug delivery strategies that may be applicable to extend their blood circulation time. We focus our research on the strategies that have been successfully applied to improve the plasma half-life of exendin-4, a clinically available toxin-derived anti-diabetic peptide drug.https://www.mdpi.com/2072-6651/12/5/313toxindiabetesanti-diabetic peptidedrug deliveryplasma half-lifecell-penetrating peptide |
| spellingShingle | Reeju Amatya Taehoon Park Seungmi Hwang JaeWook Yang Yoonjin Lee Heesun Cheong Cheol Moon Hyun Duck Kwak Kyoung Ah Min Meong Cheol Shin Drug Delivery Strategies for Enhancing the Therapeutic Efficacy of Toxin-Derived Anti-Diabetic Peptides Toxins toxin diabetes anti-diabetic peptide drug delivery plasma half-life cell-penetrating peptide |
| title | Drug Delivery Strategies for Enhancing the Therapeutic Efficacy of Toxin-Derived Anti-Diabetic Peptides |
| title_full | Drug Delivery Strategies for Enhancing the Therapeutic Efficacy of Toxin-Derived Anti-Diabetic Peptides |
| title_fullStr | Drug Delivery Strategies for Enhancing the Therapeutic Efficacy of Toxin-Derived Anti-Diabetic Peptides |
| title_full_unstemmed | Drug Delivery Strategies for Enhancing the Therapeutic Efficacy of Toxin-Derived Anti-Diabetic Peptides |
| title_short | Drug Delivery Strategies for Enhancing the Therapeutic Efficacy of Toxin-Derived Anti-Diabetic Peptides |
| title_sort | drug delivery strategies for enhancing the therapeutic efficacy of toxin derived anti diabetic peptides |
| topic | toxin diabetes anti-diabetic peptide drug delivery plasma half-life cell-penetrating peptide |
| url | https://www.mdpi.com/2072-6651/12/5/313 |
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