Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and DevelopmentSummary

Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and DevelopmentSummary

Background & Aims: Loss of Spectrin beta, non-erythrocytic 1 (SPTBN1) plays an important role in the carcinogenesis of hepatocellular carcinoma (HCC); however, the mechanisms underlying its involvement remain poorly understood. Defects in autophagy contribute to hepatic tumor formation. Henc...

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Bibliographic Details
Main Authors: Shuyi Chen, Huijie Wu, Zhengyang Wang, Mengping Jia, Jieyu Guo, Jiayu Jin, Xiaobo Li, Dan Meng, Ling Lin, Aiwu Ruth He, Ping Zhou, Xiuling Zhi
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Autophagy
Hepatic Stem Cells
Hepatocellular Carcinoma
SPTBN1
YAP Methylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X21002344

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