A cross sectional study to assess prediction of microalbuminuria using neutrophilto- lymphocyte ratio and red blood cell distribution width in diabetic patients
Background: This study was devised to evaluate the predictive value of neutrophilto- lymphocyte ratio (NLR), mean platelet volume (MPV), and red blood cell distribution width (RDW) to detect microalbuminuria in type 2 diabetic patients. This can help in early detection of microalbuminuria and assess...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-01-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/48706 |
| _version_ | 1797973757135945728 |
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| author | Manoj Kumar Bind Mayank Kumar Archana Singh Vinod Kumar Dhananjay Kumar Singh |
| author_facet | Manoj Kumar Bind Mayank Kumar Archana Singh Vinod Kumar Dhananjay Kumar Singh |
| author_sort | Manoj Kumar Bind |
| collection | DOAJ |
| description | Background: This study was devised to evaluate the predictive value of neutrophilto- lymphocyte ratio (NLR), mean platelet volume (MPV), and red blood cell distribution width (RDW) to detect microalbuminuria in type 2 diabetic patients. This can help in early detection of microalbuminuria and assessment of prognosis inn patients suffering from type 2 diabetes mellitus (DM).
Aims and Objectives: The objectives of the study were to assess the diagnostic accuracy of microalbuminuria using neutrophil-to-lymphocyte ratio and red blood cell distribution width in diabetic patients.
Materials and Methods: A total of 188 patients with type 2 DM were selected for this study. Subjects were classified into three groups based on hemoglobin A1c and microalbuminuria. Group A had 63 patients with controlled diabetes, Group B had 62 patients with uncontrolled diabetes, both without microalbuminuria, and Group C had 62 patients with uncontrolled diabetes with microalbuminuria. Levels of NLR, MPV, and RDW between the study groups were analyzed.
Results: A significant difference in NLR was found between Group C and Groups A and B (P<0.001 and P=0.005, respectively). RDW was significantly different between Groups B and C (P=0.014). Receiver operating characteristic curve analysis was done between NLR and RDW. The area under curve was found to be of 0.678 for NLR (confidence interval: 0.59–0.75, P<0.001) and 0.616 for RDW (confidence interval: 0.49–0.73, P=0.013). The study shows that an NLR cutoff point of 2.54 has 39.7% sensitivity, 78.8% specificity, and 45% positive predictive value (PPV). An RDW cutoff point of 14.44 has 37.9% sensitivity, 76% specificity, and 41.5% PPV.
Conclusion: NLR and RDW can be beneficial to detect microalbuminuria in diabetic patients. |
| first_indexed | 2024-04-11T04:09:17Z |
| format | Article |
| id | doaj.art-141fc08ca64e435a89c226ef0c28b662 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-11T04:09:17Z |
| publishDate | 2023-01-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-141fc08ca64e435a89c226ef0c28b6622023-01-01T11:55:05ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-01-011414753https://doi.org/10.3126/ajms.v14i1.48706A cross sectional study to assess prediction of microalbuminuria using neutrophilto- lymphocyte ratio and red blood cell distribution width in diabetic patientsManoj Kumar Bind 0https://orcid.org/0000-0001-6462-5649Mayank Kumar 1https://orcid.org/0000-0002-9913-3553Archana Singh 2https://orcid.org/0000-0002-8927-6999Vinod Kumar 3https://orcid.org/0000-0002-8203-7135Dhananjay Kumar Singh 4Assistant Professor, Department of Pathology, Rajarshi Dashrath Autonomous State Medical College, Ayodhya, Uttar Pradesh, India Assistant Professor, Department of Pathology, Rajarshi Dashrath Autonomous State Medical College, Ayodhya, Uttar Pradesh, India Assistant Professor, Department of Pathology, Rajarshi Dashrath Autonomous State Medical College, Ayodhya, Uttar Pradesh, India Assistant Professor, Department of General Medicine, Uma Nath Singh Autonomous State Medical College, Jaunpur, Uttar Pradesh, India Associate Professor, Department of Community Medicine, Rajarshi Dashrath Autonomous State Medical College, Ayodhya, Uttar Pradesh, IndiaBackground: This study was devised to evaluate the predictive value of neutrophilto- lymphocyte ratio (NLR), mean platelet volume (MPV), and red blood cell distribution width (RDW) to detect microalbuminuria in type 2 diabetic patients. This can help in early detection of microalbuminuria and assessment of prognosis inn patients suffering from type 2 diabetes mellitus (DM). Aims and Objectives: The objectives of the study were to assess the diagnostic accuracy of microalbuminuria using neutrophil-to-lymphocyte ratio and red blood cell distribution width in diabetic patients. Materials and Methods: A total of 188 patients with type 2 DM were selected for this study. Subjects were classified into three groups based on hemoglobin A1c and microalbuminuria. Group A had 63 patients with controlled diabetes, Group B had 62 patients with uncontrolled diabetes, both without microalbuminuria, and Group C had 62 patients with uncontrolled diabetes with microalbuminuria. Levels of NLR, MPV, and RDW between the study groups were analyzed. Results: A significant difference in NLR was found between Group C and Groups A and B (P<0.001 and P=0.005, respectively). RDW was significantly different between Groups B and C (P=0.014). Receiver operating characteristic curve analysis was done between NLR and RDW. The area under curve was found to be of 0.678 for NLR (confidence interval: 0.59–0.75, P<0.001) and 0.616 for RDW (confidence interval: 0.49–0.73, P=0.013). The study shows that an NLR cutoff point of 2.54 has 39.7% sensitivity, 78.8% specificity, and 45% positive predictive value (PPV). An RDW cutoff point of 14.44 has 37.9% sensitivity, 76% specificity, and 41.5% PPV. Conclusion: NLR and RDW can be beneficial to detect microalbuminuria in diabetic patients. https://www.nepjol.info/index.php/AJMS/article/view/48706diabetic nephropathy; inflammatory markers; microalbuminuria; neutrophil-tolymphocyte ratio; type 2 diabetes mellitus |
| spellingShingle | Manoj Kumar Bind Mayank Kumar Archana Singh Vinod Kumar Dhananjay Kumar Singh A cross sectional study to assess prediction of microalbuminuria using neutrophilto- lymphocyte ratio and red blood cell distribution width in diabetic patients Asian Journal of Medical Sciences diabetic nephropathy; inflammatory markers; microalbuminuria; neutrophil-tolymphocyte ratio; type 2 diabetes mellitus |
| title | A cross sectional study to assess prediction of microalbuminuria using neutrophilto- lymphocyte ratio and red blood cell distribution width in diabetic patients |
| title_full | A cross sectional study to assess prediction of microalbuminuria using neutrophilto- lymphocyte ratio and red blood cell distribution width in diabetic patients |
| title_fullStr | A cross sectional study to assess prediction of microalbuminuria using neutrophilto- lymphocyte ratio and red blood cell distribution width in diabetic patients |
| title_full_unstemmed | A cross sectional study to assess prediction of microalbuminuria using neutrophilto- lymphocyte ratio and red blood cell distribution width in diabetic patients |
| title_short | A cross sectional study to assess prediction of microalbuminuria using neutrophilto- lymphocyte ratio and red blood cell distribution width in diabetic patients |
| title_sort | cross sectional study to assess prediction of microalbuminuria using neutrophilto lymphocyte ratio and red blood cell distribution width in diabetic patients |
| topic | diabetic nephropathy; inflammatory markers; microalbuminuria; neutrophil-tolymphocyte ratio; type 2 diabetes mellitus |
| url | https://www.nepjol.info/index.php/AJMS/article/view/48706 |
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