PKCε Activation Restores Loss of PKCε, Manganese Superoxide Dismutase, Vascular Endothelial Growth Factor, and Microvessels in Aged and Alzheimer’s Disease Hippocampus

PKCε Activation Restores Loss of PKCε, Manganese Superoxide Dismutase, Vascular Endothelial Growth Factor, and Microvessels in Aged and Alzheimer’s Disease Hippocampus

Vascular endothelial dysfunction and capillary loss are currently considered to be a primary phenotype of normal human aging and Alzheimer’s disease (AD). Activation of protein kinase C (PKCε) improves several molecular, cellular, physiological, and behavioral endpoints, yet it is not known whether...

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Bibliographic Details
Main Authors: Guetchyn Millien, Huaixing Wang, Zongxiu Zhang, Dan L. Alkon, Jarin Hongpaisan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
aging
Alzheimer’s disease
hippocampus
PKCε
oxidative stress
microvessel
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.836634/full

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