IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening.

IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening.

CDP-ME kinase (IspE) contributes to the non-mevalonate or deoxy-xylulose phosphate (DOXP) pathway for isoprenoid precursor biosynthesis found in many species of bacteria and apicomplexan parasites. IspE has been shown to be essential by genetic methods and since it is absent from humans it constitut...

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Bibliographic Details
Main Authors: Naomi Tidten-Luksch, Raffaella Grimaldi, Leah S Torrie, Julie A Frearson, William N Hunter, Ruth Brenk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3340893?pdf=render

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