Protection of zero-valent iron nanoparticles against sepsis and septic heart failure
Abstract Background Septic heart failure accounts for high mortality rates globally. With a strong reducing capacity, zero-valent iron nanoparticles (nanoFe) have been applied in many fields. However, the precise roles and mechanisms of nanoFe in septic cardiomyopathy remain unknown. Results NanoFe...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01589-1 |
| _version_ | 1818064749710016512 |
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| author | Daquan Wang Changyu Wang Zhenxing Liang Wangrui Lei Chao Deng Xiaoli Liu Shuai Jiang Yanli Zhu Shaofei Zhang Wenwen Yang Ying Chen Yao Qiu Lingjie Meng Yang Yang |
| author_facet | Daquan Wang Changyu Wang Zhenxing Liang Wangrui Lei Chao Deng Xiaoli Liu Shuai Jiang Yanli Zhu Shaofei Zhang Wenwen Yang Ying Chen Yao Qiu Lingjie Meng Yang Yang |
| author_sort | Daquan Wang |
| collection | DOAJ |
| description | Abstract Background Septic heart failure accounts for high mortality rates globally. With a strong reducing capacity, zero-valent iron nanoparticles (nanoFe) have been applied in many fields. However, the precise roles and mechanisms of nanoFe in septic cardiomyopathy remain unknown. Results NanoFe was prepared via the liquid-phase reduction method and functionalized with the biocompatible polymer sodium carboxymethylcellulose (CMC). We then successfully constructed a mouse model of septic myocardial injury by challenging with cecal ligation and puncture (CLP). Our findings demonstrated that nanoFe has a significant protective effect on CLP-induced septic myocardial injury. This may be achieved by attenuating inflammation and oxidative stress, improving mitochondrial function, regulating endoplasmic reticulum stress, and activating the AMPK pathway. The RNA-seq results supported the role of nanoFe treatment in regulating a transcriptional profile consistent with its role in response to sepsis. Conclusions The results provide a theoretical basis for the application strategy and combination of nanoFe in sepsis and septic myocardial injury. Graphical Abstract |
| first_indexed | 2024-12-10T14:40:57Z |
| format | Article |
| id | doaj.art-142a0430ee2d480987a87ffc0d02b65d |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-12-10T14:40:57Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-142a0430ee2d480987a87ffc0d02b65d2022-12-22T01:44:41ZengBMCJournal of Nanobiotechnology1477-31552022-09-0120112210.1186/s12951-022-01589-1Protection of zero-valent iron nanoparticles against sepsis and septic heart failureDaquan Wang0Changyu Wang1Zhenxing Liang2Wangrui Lei3Chao Deng4Xiaoli Liu5Shuai Jiang6Yanli Zhu7Shaofei Zhang8Wenwen Yang9Ying Chen10Yao Qiu11Lingjie Meng12Yang Yang13Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest UniversityKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest UniversityDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Zhengzhou UniversityKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest UniversityDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest UniversityKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest UniversityKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest UniversityKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest UniversityKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest UniversityDepartment of Hematology, The First Affiliated Hospital of Xi’an Jiaotong UniversitySchool of Chemistry, Xi’an Jiaotong UniversitySchool of Chemistry, Xi’an Jiaotong UniversityKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest UniversityAbstract Background Septic heart failure accounts for high mortality rates globally. With a strong reducing capacity, zero-valent iron nanoparticles (nanoFe) have been applied in many fields. However, the precise roles and mechanisms of nanoFe in septic cardiomyopathy remain unknown. Results NanoFe was prepared via the liquid-phase reduction method and functionalized with the biocompatible polymer sodium carboxymethylcellulose (CMC). We then successfully constructed a mouse model of septic myocardial injury by challenging with cecal ligation and puncture (CLP). Our findings demonstrated that nanoFe has a significant protective effect on CLP-induced septic myocardial injury. This may be achieved by attenuating inflammation and oxidative stress, improving mitochondrial function, regulating endoplasmic reticulum stress, and activating the AMPK pathway. The RNA-seq results supported the role of nanoFe treatment in regulating a transcriptional profile consistent with its role in response to sepsis. Conclusions The results provide a theoretical basis for the application strategy and combination of nanoFe in sepsis and septic myocardial injury. Graphical Abstracthttps://doi.org/10.1186/s12951-022-01589-1NanoFeSepsisHeart failure |
| spellingShingle | Daquan Wang Changyu Wang Zhenxing Liang Wangrui Lei Chao Deng Xiaoli Liu Shuai Jiang Yanli Zhu Shaofei Zhang Wenwen Yang Ying Chen Yao Qiu Lingjie Meng Yang Yang Protection of zero-valent iron nanoparticles against sepsis and septic heart failure Journal of Nanobiotechnology NanoFe Sepsis Heart failure |
| title | Protection of zero-valent iron nanoparticles against sepsis and septic heart failure |
| title_full | Protection of zero-valent iron nanoparticles against sepsis and septic heart failure |
| title_fullStr | Protection of zero-valent iron nanoparticles against sepsis and septic heart failure |
| title_full_unstemmed | Protection of zero-valent iron nanoparticles against sepsis and septic heart failure |
| title_short | Protection of zero-valent iron nanoparticles against sepsis and septic heart failure |
| title_sort | protection of zero valent iron nanoparticles against sepsis and septic heart failure |
| topic | NanoFe Sepsis Heart failure |
| url | https://doi.org/10.1186/s12951-022-01589-1 |
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