IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models

IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models

Interleukin 15 (IL-15) has been evaluated as a potential treatment for solid tumors in clinical trials, but the effectiveness of systemic IL-15 administration as a monotherapy has not been realized. IL-15 receptor alpha (IL-15Rα) can stabilize IL-15 and enhance its bioactivity. The goal of this stud...

Full description

Bibliographic Details
Main Authors:	Siqi Guo, Ronald B. Smeltz, Anthony Nanajian, Richard Heller
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Immunology
Subjects:	breast cancer interleukin-15/interleukin-15 receptor alpha complex cancer immunotherapy gene electrotransfer depletion of myeloid derived suppressor cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.614667/full

Similar Items

Heterodimeric IL-15 in Cancer Immunotherapy
by: Cristina Bergamaschi, et al.
Published: (2021-02-01)

Co-expression IL-15 receptor alpha with IL-15 reduces toxicity via limiting IL-15 systemic exposure during CAR-T immunotherapy
by: Ying Zhang, et al.
Published: (2022-09-01)

Immunomodulatory Effects of IL-2 and IL-15; Implications for Cancer Immunotherapy
by: Ying Yang, et al.
Published: (2020-11-01)

Interleukin-15 in cancer immunotherapy: IL-15 receptor complex versus soluble IL-15 in a cancer cell-delivered murine leukemia model
by: Alexandra Berger, et al.
Published: (2019-12-01)

IL-15 in the Combination Immunotherapy of Cancer
by: Thomas A. Waldmann, et al.
Published: (2020-05-01)

IL-15 and IL15RA in Osteoarthritis: Association With Symptoms and Protease Production, but Not Structural Severity
by: Sophie C. Warner, et al.
Published: (2020-07-01)

Immunological Effects and Viral Gene Expression Determine the Efficacy of Oncolytic Measles Vaccines Encoding IL-12 or IL-15 Agonists
by: Paul S. Backhaus, et al.
Published: (2019-10-01)

Protective and Therapeutic Effects of an IL-15:IL-15Rα-Secreting Cell-Based Cancer Vaccine Using a Baculovirus System
by: Van Anh Do-Thi, et al.
Published: (2021-08-01)

Research progress of interleukin-15 in cancer immunotherapy
by: Menghan Cai, et al.
Published: (2023-05-01)

Interleukin 15 in Cell-Based Cancer Immunotherapy
by: Yang Zhou, et al.
Published: (2022-06-01)

IL-15 and a Two-Step Maturation Process Improve Bone Marrow-Derived Dendritic Cell Cancer Vaccine
by: Ananda Mookerjee, et al.
Published: (2019-01-01)

Oncolytic therapy with recombinant vaccinia viruses targeting the interleukin-15 pathway elicits a synergistic response
by: Yasmin Shakiba, et al.
Published: (2023-06-01)

Investigation of the Impact from IL-2, IL-7, and IL-15 on the Growth and Signaling of Activated CD4<sup>+</sup> T Cells
by: Canaan Coppola, et al.
Published: (2020-10-01)

Inhibition of MC38 colon cancer growth by multicomponent chemoimmunotherapy with anti-IL-10R antibodies, HES-MTX nanoconjugate, depends on application of IL-12, IL-15 or IL-18 secreting dendritic cell vaccines
by: Katarzyna Węgierek-Ciura, et al.
Published: (2023-07-01)

Combination of Interleukin-15 With a STING Agonist, ADU-S100 Analog: A Potential Immunotherapy for Prostate Cancer
by: Ana M. Esteves, et al.
Published: (2021-03-01)

Mechanistic and Structural Insights on the IL-15 System through Molecular Dynamics Simulations
by: Rui P. Sousa, et al.
Published: (2019-09-01)

GT-00AxIL15, a Novel Tumor-Targeted IL-15-Based Immunocytokine for the Treatment of TA-MUC1-Positive Solid Tumors: Preclinical In Vitro and In Vivo Pharmacodynamics and Biodistribution Studies
by: Johanna Gellert, et al.
Published: (2024-01-01)

SON-1210 - a novel bifunctional IL-12 / IL-15 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy
by: John K. Cini, et al.
Published: (2023-12-01)

Proinflammatory Cytokines (IL-1, -6, -8, -15, -17, -18, -23, TNF-α) Single Nucleotide Polymorphisms in Rheumatoid Arthritis—A Literature Review
by: Olga M. Koper-Lenkiewicz, et al.
Published: (2022-02-01)

Development of IL-15/IL-15Rα sushi domain-IgG4 Fc complexes in Pichia pastoris with potent activities and prolonged half-lives
by: Huan Xu, et al.
Published: (2021-06-01)

Serum interleukin 15 as a marker of activity in patients with vitiligo
by: Ashraf Hamza, et al.
Published: (2021-01-01)

IL-15 Upregulates Telomerase Expression and Potently Increases Proliferative Capacity of NK, NKT-Like, and CD8 T Cells
by: Fiona Watkinson, et al.
Published: (2021-01-01)

Restoration of IL-11 and IL-15 cytokine production post calcium modulators and ROS treatment can assist viral clearance both in vitro and in vivo
by: Kehkshan Jabeen, et al.
Published: (2023-02-01)

IL-27 enhances IL-15/IL-18-mediated activation of human natural killer cells
by: Yeon Ho Choi, et al.
Published: (2019-07-01)

Low-Dose rIL-15 Protects from Nephrotoxic Serum Nephritis via CD8<sup>+</sup> T Cells
by: Agnes A. Mooslechner, et al.
Published: (2022-11-01)

A novel multimeric IL15/IL15Rα-Fc complex to enhance cancer immunotherapy
by: Hong Xu, et al.
Published: (2021-01-01)

Scalable, cGMP-compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL-15/lactadherin complexes
by: Dionysios C. Watson, et al.
Published: (2018-12-01)

Safety and Efficacy of IL-12 Plasmid DNA Transfection into Pig Skin: Supportive Data for Human Clinical Trials on Gene Therapy and Vaccination
by: Ursa Lampreht Tratar, et al.
Published: (2024-03-01)

A peptoid interleukin‐15 receptor antagonist suppresses inflammation and arthritis in mice
by: Kwang Bog Cho, et al.
Published: (2022-01-01)

Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer
by: Jingwei Shi, et al.
Published: (2021-03-01)

Elevated Serum Levels of Interleukin-15 in Pemphigus Vulgaris Patients: A Potential Therapeutic Target
by: Maedeh Kheirodin, et al.
Published: (2022-07-01)

Novel combination immunotherapy for pancreatic cancer: potent anti‐tumor effects with CD40 agonist and interleukin‐15 treatment
by: Jonas RM Van Audenaerde, et al.
Published: (2020-01-01)

Electrotransfer of IL-15/IL-15Rα Complex for the Treatment of Established Melanoma
by: Shawna A. Shirley, et al.
Published: (2020-10-01)

Heterodimeric IL-15 (hetIL-15) reduces circulating tumor cells and metastasis formation improving chemotherapy and surgery in 4T1 mouse model of TNBC
by: Vasiliki Stravokefalou, et al.
Published: (2023-01-01)

Exploiting an Interleukin-15 Heterodimeric Agonist (N803) for Effective Immunotherapy of Solid Malignancies
by: Grace Lui, et al.
Published: (2023-06-01)

Interleukin-15 as a potential regulator of the innate immune response
by: W. Carson, et al.
Published: (1998-01-01)

Non-Clinical In Vitro Evaluation of Antibiotic Resistance Gene-Free Plasmids Encoding Human or Murine IL-12 Intended for First-in-Human Clinical Study
by: Spela Kos, et al.
Published: (2021-10-01)

Monocytic Myeloid-Derived Suppressor Cells Inhibit Myofibroblastic Differentiation in Mesenchymal Stem Cells Through IL-15 Secretion
by: Yin Celeste Cheuk, et al.
Published: (2022-02-01)

Effect of a Cross-Training and Resistance Exercise Routine on IL-15 in Adults with Type B Acute Lymphoblastic Leukemia during the Induction Phase: Randomized Pilot Study
by: Adán Germán Gallardo Rodríguez, et al.
Published: (2023-12-01)

Effect of Interleukin-15 Receptor Alpha Ablation on the Metabolic Responses to Moderate Exercise Simulated by in vivo Isometric Muscle Contractions
by: Emanuele Loro, et al.
Published: (2019-11-01)