Aging and recurrent urinary tract infections are associated with bladder dysfunction in type 2 diabetes
Objective: The objective of this study was to demonstrate the diversity of urodynamic findings and temporal effects on bladder dysfunction in diabetes as well as to evaluate the predisposing factors that attenuate the storage and voiding function of diabetic women. Material and Methods: In this pros...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-09-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455912001258 |
| _version_ | 1818132058617151488 |
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| author | Tzu-Li Lin Gin-Den Chen Yi-Ching Chen Chien-Ning Huang Soo-Cheen Ng |
| author_facet | Tzu-Li Lin Gin-Den Chen Yi-Ching Chen Chien-Ning Huang Soo-Cheen Ng |
| author_sort | Tzu-Li Lin |
| collection | DOAJ |
| description | Objective: The objective of this study was to demonstrate the diversity of urodynamic findings and temporal effects on bladder dysfunction in diabetes as well as to evaluate the predisposing factors that attenuate the storage and voiding function of diabetic women.
Material and Methods: In this prospective study, 181 women with type 2 diabetes mellitus (DM) and lower urinary tract dysfunction underwent complete urogynecological evaluations and urodynamic studies. The patients' histories of DM and the treatment agents used were documented from chart records and interviews. The urodynamic diagnoses were recategorized into two groups for comparison, namely overactive detrusor (detrusor overactivity and/or increased bladder sensation as well as mixed incontinence) and voiding dysfunction (detrusor hyperactivity with insufficient contractility and detrusor underactivity with poor voiding efficiency) in order to evaluate the temporal effect of DM on diabetic bladder dysfunction.
Results: The development of bladder dysfunction showed a trend involving time-dependent progression, beginning with storage problems (i.e. advancing from urodynamic stress incontinence to detrusor overactivity and/or increased bladder sensation) and eventually led to impaired voiding function. The duration of DM relative to the urodynamic diagnoses of these women was longer in women with voiding dysfunction (6.8 ± 2.8 years with urodynamic stress incontinence, 7.3 ± 6.5 years with detrusor overactivity and/or increased bladder sensation, and 10.4 ± 8.3 years with women with voiding dysfunction). Notwithstanding these findings, stepwise logistic regression analysis indicated that age and recurrent urinary tract infections were the two independent factors associated with developing voiding dysfunction.
Conclusion: The urodynamic study revealed a temporal effect on bladder function, and women with diabetic voiding dysfunction were found to have had a longer duration of DM than women with an overactive detrusor. However, aging and recurrent urinary tract infections are the two independent factors that contribute to impaired voiding function and diabetic bladder dysfunction. |
| first_indexed | 2024-12-11T08:30:48Z |
| format | Article |
| id | doaj.art-142ad91c1bc54a03881667b6710c2f08 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-11T08:30:48Z |
| publishDate | 2012-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-142ad91c1bc54a03881667b6710c2f082022-12-22T01:14:28ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592012-09-0151338138610.1016/j.tjog.2012.07.011Aging and recurrent urinary tract infections are associated with bladder dysfunction in type 2 diabetesTzu-Li Lin0Gin-Den Chen1Yi-Ching Chen2Chien-Ning Huang3Soo-Cheen Ng4Department of Living Sciences, National Open University, TaiwanDepartment of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, TaiwanSchool of Physical Therapy, Chung Shan Medical University, Taichung, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, TaiwanObjective: The objective of this study was to demonstrate the diversity of urodynamic findings and temporal effects on bladder dysfunction in diabetes as well as to evaluate the predisposing factors that attenuate the storage and voiding function of diabetic women. Material and Methods: In this prospective study, 181 women with type 2 diabetes mellitus (DM) and lower urinary tract dysfunction underwent complete urogynecological evaluations and urodynamic studies. The patients' histories of DM and the treatment agents used were documented from chart records and interviews. The urodynamic diagnoses were recategorized into two groups for comparison, namely overactive detrusor (detrusor overactivity and/or increased bladder sensation as well as mixed incontinence) and voiding dysfunction (detrusor hyperactivity with insufficient contractility and detrusor underactivity with poor voiding efficiency) in order to evaluate the temporal effect of DM on diabetic bladder dysfunction. Results: The development of bladder dysfunction showed a trend involving time-dependent progression, beginning with storage problems (i.e. advancing from urodynamic stress incontinence to detrusor overactivity and/or increased bladder sensation) and eventually led to impaired voiding function. The duration of DM relative to the urodynamic diagnoses of these women was longer in women with voiding dysfunction (6.8 ± 2.8 years with urodynamic stress incontinence, 7.3 ± 6.5 years with detrusor overactivity and/or increased bladder sensation, and 10.4 ± 8.3 years with women with voiding dysfunction). Notwithstanding these findings, stepwise logistic regression analysis indicated that age and recurrent urinary tract infections were the two independent factors associated with developing voiding dysfunction. Conclusion: The urodynamic study revealed a temporal effect on bladder function, and women with diabetic voiding dysfunction were found to have had a longer duration of DM than women with an overactive detrusor. However, aging and recurrent urinary tract infections are the two independent factors that contribute to impaired voiding function and diabetic bladder dysfunction.http://www.sciencedirect.com/science/article/pii/S1028455912001258agediabetes mellitusdiabetic cystopathyoveractive detrusorurinary tract infectionvoiding dysfunction |
| spellingShingle | Tzu-Li Lin Gin-Den Chen Yi-Ching Chen Chien-Ning Huang Soo-Cheen Ng Aging and recurrent urinary tract infections are associated with bladder dysfunction in type 2 diabetes Taiwanese Journal of Obstetrics & Gynecology age diabetes mellitus diabetic cystopathy overactive detrusor urinary tract infection voiding dysfunction |
| title | Aging and recurrent urinary tract infections are associated with bladder dysfunction in type 2 diabetes |
| title_full | Aging and recurrent urinary tract infections are associated with bladder dysfunction in type 2 diabetes |
| title_fullStr | Aging and recurrent urinary tract infections are associated with bladder dysfunction in type 2 diabetes |
| title_full_unstemmed | Aging and recurrent urinary tract infections are associated with bladder dysfunction in type 2 diabetes |
| title_short | Aging and recurrent urinary tract infections are associated with bladder dysfunction in type 2 diabetes |
| title_sort | aging and recurrent urinary tract infections are associated with bladder dysfunction in type 2 diabetes |
| topic | age diabetes mellitus diabetic cystopathy overactive detrusor urinary tract infection voiding dysfunction |
| url | http://www.sciencedirect.com/science/article/pii/S1028455912001258 |
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