Continuous multistep synthesis of 2-(azidomethyl)oxazoles

Continuous multistep synthesis of 2-(azidomethyl)oxazoles

An efficient three-step protocol was developed to produce 2-(azidomethyl)oxazoles from vinyl azides in a continuous-flow process. The general synthetic strategy involves a thermolysis of vinyl azides to generate azirines, which react with bromoacetyl bromide to provide 2-(bromomethyl)oxazoles. The l...

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Bibliographic Details
Main Authors:	Thaís A. Rossa, Nícolas S. Suveges, Marcus M. Sá, David Cantillo, C. Oliver Kappe
Format:	Article
Language:	English
Published:	Beilstein-Institut 2018-02-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	azirines continuous flow heterocycles oxazoles process integration vinyl azides
Online Access:	https://doi.org/10.3762/bjoc.14.36

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