Severe Candida infections in critically ill patients with COVID-19
The frequency of co-infections with bacterial or fungal pathogens has constantly increased among critically ill patients with coronavirus disease 2019 (COVID-19) during the pandemic. Candidemia was the most frequently reported invasive fungal co-infection. The onset of candidemia in COVID-19 patient...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Journal of Intensive Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667100X23000531 |
| _version_ | 1797640248134467584 |
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| author | Despoina Koulenti Marios Karvouniaris Elisabeth Paramythiotou Nikolaos Koliakos Nikolaos Markou Paschalis Paranos Joseph Meletiadis Stijn Blot |
| author_facet | Despoina Koulenti Marios Karvouniaris Elisabeth Paramythiotou Nikolaos Koliakos Nikolaos Markou Paschalis Paranos Joseph Meletiadis Stijn Blot |
| author_sort | Despoina Koulenti |
| collection | DOAJ |
| description | The frequency of co-infections with bacterial or fungal pathogens has constantly increased among critically ill patients with coronavirus disease 2019 (COVID-19) during the pandemic. Candidemia was the most frequently reported invasive fungal co-infection. The onset of candidemia in COVID-19 patients was often delayed compared to non-COVID-19 patients. Additionally, Candida invasive infections in COVID-19 patients were more often linked to invasive procedures (e.g., invasive mechanical ventilation or renal replacement therapy) during the intensive care stay and the severity of illness rather than more “classic” risk factors present in patients without COVID-19 (e.g., underlying diseases and prior hospitalization). Moreover, apart from the increased incidence of candidemia during the pandemic, a worrying rise in fluconazole-resistant strains was reported, including a rise in the multidrug-resistant Candida auris. Regarding outcomes, the development of invasive Candida co-infection had a negative impact, increasing morbidity and mortality compared to non-co-infected COVID-19 patients. In this narrative review, we present and critically discuss information on the diagnosis and management of invasive fungal infections caused by Candida spp. in critically ill COVID-19 patients. |
| first_indexed | 2024-03-11T13:28:07Z |
| format | Article |
| id | doaj.art-142e794285d1451c9494044e358924f5 |
| institution | Directory Open Access Journal |
| issn | 2667-100X |
| language | English |
| last_indexed | 2024-03-11T13:28:07Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Intensive Medicine |
| spelling | doaj.art-142e794285d1451c9494044e358924f52023-11-03T04:15:15ZengElsevierJournal of Intensive Medicine2667-100X2023-10-0134291297Severe Candida infections in critically ill patients with COVID-19Despoina Koulenti0Marios Karvouniaris1Elisabeth Paramythiotou2Nikolaos Koliakos3Nikolaos Markou4Paschalis Paranos5Joseph Meletiadis6Stijn Blot7Second Critical Care Department, Attikon University Hospital, Athens, Greece; UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia; Corresponding author: Despoina Koulenti, Second Critical Care Department, Attikon University Hospital, Athens, Greece.Intensive Care Unit, ACHEPA University Hospital, Thessaloniki, GreeceSecond Critical Care Department, Attikon University Hospital, Athens, GreeceSecond Critical Care Department, Attikon University Hospital, Athens, GreeceICU of Latseio Burns Centre, General Hospital of Elefsis ‘Thriasio’, Athens, GreeceClinical Microbiology Laboratory, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, GreeceClinical Microbiology Laboratory, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, GreeceUQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, BelgiumThe frequency of co-infections with bacterial or fungal pathogens has constantly increased among critically ill patients with coronavirus disease 2019 (COVID-19) during the pandemic. Candidemia was the most frequently reported invasive fungal co-infection. The onset of candidemia in COVID-19 patients was often delayed compared to non-COVID-19 patients. Additionally, Candida invasive infections in COVID-19 patients were more often linked to invasive procedures (e.g., invasive mechanical ventilation or renal replacement therapy) during the intensive care stay and the severity of illness rather than more “classic” risk factors present in patients without COVID-19 (e.g., underlying diseases and prior hospitalization). Moreover, apart from the increased incidence of candidemia during the pandemic, a worrying rise in fluconazole-resistant strains was reported, including a rise in the multidrug-resistant Candida auris. Regarding outcomes, the development of invasive Candida co-infection had a negative impact, increasing morbidity and mortality compared to non-co-infected COVID-19 patients. In this narrative review, we present and critically discuss information on the diagnosis and management of invasive fungal infections caused by Candida spp. in critically ill COVID-19 patients.http://www.sciencedirect.com/science/article/pii/S2667100X23000531Critical illnessCOVID-19AntifungalsCandidiasisCandida spp.Candida auris |
| spellingShingle | Despoina Koulenti Marios Karvouniaris Elisabeth Paramythiotou Nikolaos Koliakos Nikolaos Markou Paschalis Paranos Joseph Meletiadis Stijn Blot Severe Candida infections in critically ill patients with COVID-19 Journal of Intensive Medicine Critical illness COVID-19 Antifungals Candidiasis Candida spp. Candida auris |
| title | Severe Candida infections in critically ill patients with COVID-19 |
| title_full | Severe Candida infections in critically ill patients with COVID-19 |
| title_fullStr | Severe Candida infections in critically ill patients with COVID-19 |
| title_full_unstemmed | Severe Candida infections in critically ill patients with COVID-19 |
| title_short | Severe Candida infections in critically ill patients with COVID-19 |
| title_sort | severe candida infections in critically ill patients with covid 19 |
| topic | Critical illness COVID-19 Antifungals Candidiasis Candida spp. Candida auris |
| url | http://www.sciencedirect.com/science/article/pii/S2667100X23000531 |
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