Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon.
<h4>Introduction</h4>Human T-cell lymphotrophic virus type-1 (HTLV-1) and human immunodeficiency virus (HIV-1) co-infection occur in many populations. People living with HIV-1 and infected with HTLV-1 seem more likely to progress rapidly towards AIDS. Both HTLV-1 and HIV-1 are endemic in...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0271320&type=printable |
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| author | Augustin Mouinga-Ondémé Larson Boundenga Ingrid Précilya Koumba Koumba Antony Idam Mamimandjiami Abdoulaye Diané Jéordy Dimitri Engone-Ondo Delia Doreen Djuicy Jeanne Sica Landry Erik Mombo Antoine Gessain Avelin Aghokeng Fobang |
| author_facet | Augustin Mouinga-Ondémé Larson Boundenga Ingrid Précilya Koumba Koumba Antony Idam Mamimandjiami Abdoulaye Diané Jéordy Dimitri Engone-Ondo Delia Doreen Djuicy Jeanne Sica Landry Erik Mombo Antoine Gessain Avelin Aghokeng Fobang |
| author_sort | Augustin Mouinga-Ondémé |
| collection | DOAJ |
| description | <h4>Introduction</h4>Human T-cell lymphotrophic virus type-1 (HTLV-1) and human immunodeficiency virus (HIV-1) co-infection occur in many populations. People living with HIV-1 and infected with HTLV-1 seem more likely to progress rapidly towards AIDS. Both HTLV-1 and HIV-1 are endemic in Gabon (Central Africa). We investigated HTLV-1 and HIV-1 co-infection in the Haut-Ogooué province, and assessed factors that may favor the rapid evolution and progression to AIDS in co-infected patients.<h4>Methods</h4>Plasma samples from HTLV-1 patients were tested using ELISA, and positive samples were then tested by western blot assay (WB). We used the polymerase chain reaction to detect HTLV-1 Tax/Rex genes using DNA extracted from the buffy coat of ELISA-positives samples.<h4>Results</h4>We recruited 299 individuals (mean age 46 years) including 90 (30%) men and 209 (70%) women, all of whom are under treatment at the Ambulatory Treatment Centre of the province. Of these, 45 were ELISA HTLV-1/2 seropositive. According to WB criteria, 21 of 45 were confirmed positive: 20 were HTLV-1 (44%), 1 was HTLV-1/2 (2%), 2 were indeterminate (4%) and 22 were seronegative (49%). PCR results showed that 23 individuals were positive for the Tax/Rex region. Considering both serological and molecular assays, the prevalence of HTLV-1 infection was estimated at 7.7%. Being a woman and increasing age were found to be independent risk factors for co-infection. Mean CD4+ cell counts were higher in HTLV-1/HIV-1 co-infected (578.1 (± 340.8) cells/mm3) than in HIV-1 mono-infected (481.0 (± 299.0) cells/mm3) Individuals. Similarly, the mean HIV-1 viral load was Log 3.0 (± 1.6) copies/ml in mono-infected and Log 2.3 (± 0.7) copies/ml in coinfected individuals.<h4>Conclusion</h4>We described an overall high prevalence of HTLV-1/HIV-1 co-infection in Gabon. Our findings stress the need of strategies to prevent and manage these co-infections. |
| first_indexed | 2024-04-12T08:26:07Z |
| format | Article |
| id | doaj.art-14302170e6384b518edc48d2f50435b4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2025-03-14T05:24:07Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-14302170e6384b518edc48d2f50435b42025-03-06T05:31:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01177e027132010.1371/journal.pone.0271320Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon.Augustin Mouinga-OndéméLarson BoundengaIngrid Précilya Koumba KoumbaAntony Idam MamimandjiamiAbdoulaye DianéJéordy Dimitri Engone-OndoDelia Doreen DjuicyJeanne SicaLandry Erik MomboAntoine GessainAvelin Aghokeng Fobang<h4>Introduction</h4>Human T-cell lymphotrophic virus type-1 (HTLV-1) and human immunodeficiency virus (HIV-1) co-infection occur in many populations. People living with HIV-1 and infected with HTLV-1 seem more likely to progress rapidly towards AIDS. Both HTLV-1 and HIV-1 are endemic in Gabon (Central Africa). We investigated HTLV-1 and HIV-1 co-infection in the Haut-Ogooué province, and assessed factors that may favor the rapid evolution and progression to AIDS in co-infected patients.<h4>Methods</h4>Plasma samples from HTLV-1 patients were tested using ELISA, and positive samples were then tested by western blot assay (WB). We used the polymerase chain reaction to detect HTLV-1 Tax/Rex genes using DNA extracted from the buffy coat of ELISA-positives samples.<h4>Results</h4>We recruited 299 individuals (mean age 46 years) including 90 (30%) men and 209 (70%) women, all of whom are under treatment at the Ambulatory Treatment Centre of the province. Of these, 45 were ELISA HTLV-1/2 seropositive. According to WB criteria, 21 of 45 were confirmed positive: 20 were HTLV-1 (44%), 1 was HTLV-1/2 (2%), 2 were indeterminate (4%) and 22 were seronegative (49%). PCR results showed that 23 individuals were positive for the Tax/Rex region. Considering both serological and molecular assays, the prevalence of HTLV-1 infection was estimated at 7.7%. Being a woman and increasing age were found to be independent risk factors for co-infection. Mean CD4+ cell counts were higher in HTLV-1/HIV-1 co-infected (578.1 (± 340.8) cells/mm3) than in HIV-1 mono-infected (481.0 (± 299.0) cells/mm3) Individuals. Similarly, the mean HIV-1 viral load was Log 3.0 (± 1.6) copies/ml in mono-infected and Log 2.3 (± 0.7) copies/ml in coinfected individuals.<h4>Conclusion</h4>We described an overall high prevalence of HTLV-1/HIV-1 co-infection in Gabon. Our findings stress the need of strategies to prevent and manage these co-infections.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0271320&type=printable |
| spellingShingle | Augustin Mouinga-Ondémé Larson Boundenga Ingrid Précilya Koumba Koumba Antony Idam Mamimandjiami Abdoulaye Diané Jéordy Dimitri Engone-Ondo Delia Doreen Djuicy Jeanne Sica Landry Erik Mombo Antoine Gessain Avelin Aghokeng Fobang Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon. PLoS ONE |
| title | Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon. |
| title_full | Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon. |
| title_fullStr | Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon. |
| title_full_unstemmed | Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon. |
| title_short | Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon. |
| title_sort | human t lymphotropic virus type 1 and human immunodeficiency virus co infection in rural gabon |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0271320&type=printable |
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