From Genes to Therapy: Pituitary Adenomas in the Era of Precision Medicine
This review presents a comprehensive analysis of pituitary adenomas, a type of brain tumor with diverse behaviors and complexities. We cover various treatment approaches, including surgery, radiotherapy, chemotherapy, and their integration with newer treatments. Key to the discussion is the role of...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/1/23 |
| _version_ | 1797340059989442560 |
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| author | Corneliu Toader Nicolaie Dobrin Catalina-Ioana Tataru Razvan-Adrian Covache-Busuioc Bogdan-Gabriel Bratu Luca Andrei Glavan Horia Petre Costin Antonio Daniel Corlatescu David-Ioan Dumitrascu Alexandru Vlad Ciurea |
| author_facet | Corneliu Toader Nicolaie Dobrin Catalina-Ioana Tataru Razvan-Adrian Covache-Busuioc Bogdan-Gabriel Bratu Luca Andrei Glavan Horia Petre Costin Antonio Daniel Corlatescu David-Ioan Dumitrascu Alexandru Vlad Ciurea |
| author_sort | Corneliu Toader |
| collection | DOAJ |
| description | This review presents a comprehensive analysis of pituitary adenomas, a type of brain tumor with diverse behaviors and complexities. We cover various treatment approaches, including surgery, radiotherapy, chemotherapy, and their integration with newer treatments. Key to the discussion is the role of biomarkers in oncology for risk assessment, diagnosis, prognosis, and the monitoring of pituitary adenomas. We highlight advances in genomic, epigenomic, and transcriptomic analyses and their contributions to understanding the pathogenesis and molecular pathology of these tumors. Special attention is given to the molecular mechanisms, including the impact of epigenetic factors like histone modifications, DNA methylation, and transcriptomic changes on different subtypes of pituitary adenomas. The importance of the tumor immune microenvironment in tumor behavior and treatment response is thoroughly analyzed. We highlight potential breakthroughs and innovations for a more effective management and treatment of pituitary adenomas, while shedding light on the ongoing need for research and development in this field to translate scientific knowledge into clinical advancements, aiming to improve patient outcomes. |
| first_indexed | 2024-03-08T09:57:29Z |
| format | Article |
| id | doaj.art-143025bf66f04df3914507d5866da7d2 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-08T09:57:29Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-143025bf66f04df3914507d5866da7d22024-01-29T13:46:36ZengMDPI AGBiomedicines2227-90592023-12-011212310.3390/biomedicines12010023From Genes to Therapy: Pituitary Adenomas in the Era of Precision MedicineCorneliu Toader0Nicolaie Dobrin1Catalina-Ioana Tataru2Razvan-Adrian Covache-Busuioc3Bogdan-Gabriel Bratu4Luca Andrei Glavan5Horia Petre Costin6Antonio Daniel Corlatescu7David-Ioan Dumitrascu8Alexandru Vlad Ciurea9Department of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaNeurosurgical Clinic, “Prof. Dr. N. Oblu” Emergency Clinical Hospital, 700309 Iași, RomaniaDepartment of Ophthalmology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaThis review presents a comprehensive analysis of pituitary adenomas, a type of brain tumor with diverse behaviors and complexities. We cover various treatment approaches, including surgery, radiotherapy, chemotherapy, and their integration with newer treatments. Key to the discussion is the role of biomarkers in oncology for risk assessment, diagnosis, prognosis, and the monitoring of pituitary adenomas. We highlight advances in genomic, epigenomic, and transcriptomic analyses and their contributions to understanding the pathogenesis and molecular pathology of these tumors. Special attention is given to the molecular mechanisms, including the impact of epigenetic factors like histone modifications, DNA methylation, and transcriptomic changes on different subtypes of pituitary adenomas. The importance of the tumor immune microenvironment in tumor behavior and treatment response is thoroughly analyzed. We highlight potential breakthroughs and innovations for a more effective management and treatment of pituitary adenomas, while shedding light on the ongoing need for research and development in this field to translate scientific knowledge into clinical advancements, aiming to improve patient outcomes.https://www.mdpi.com/2227-9059/12/1/23pituitary adenomasmolecular mechanismstargeted therapiesimmunotherapybiomarkersepigenetics |
| spellingShingle | Corneliu Toader Nicolaie Dobrin Catalina-Ioana Tataru Razvan-Adrian Covache-Busuioc Bogdan-Gabriel Bratu Luca Andrei Glavan Horia Petre Costin Antonio Daniel Corlatescu David-Ioan Dumitrascu Alexandru Vlad Ciurea From Genes to Therapy: Pituitary Adenomas in the Era of Precision Medicine Biomedicines pituitary adenomas molecular mechanisms targeted therapies immunotherapy biomarkers epigenetics |
| title | From Genes to Therapy: Pituitary Adenomas in the Era of Precision Medicine |
| title_full | From Genes to Therapy: Pituitary Adenomas in the Era of Precision Medicine |
| title_fullStr | From Genes to Therapy: Pituitary Adenomas in the Era of Precision Medicine |
| title_full_unstemmed | From Genes to Therapy: Pituitary Adenomas in the Era of Precision Medicine |
| title_short | From Genes to Therapy: Pituitary Adenomas in the Era of Precision Medicine |
| title_sort | from genes to therapy pituitary adenomas in the era of precision medicine |
| topic | pituitary adenomas molecular mechanisms targeted therapies immunotherapy biomarkers epigenetics |
| url | https://www.mdpi.com/2227-9059/12/1/23 |
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