From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin
Cytolethal distending toxin (CDT), one of the most important genotoxins, is produced by several gram-negative bacteria and is involved in bacterial pathogenesis. Recent studies have shown that bacteria producing this peculiar genotoxin target host DNA, which potentially contributes to development of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.760451/full |
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| author | Yi-Ru Lai Yi-Ru Lai Yu-Fang Chang Yu-Fang Chang Jason Ma Jason Ma Cheng-Hsun Chiu Cheng-Hsun Chiu Cheng-Hsun Chiu Ming-Ling Kuo Ming-Ling Kuo Ming-Ling Kuo Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai |
| author_facet | Yi-Ru Lai Yi-Ru Lai Yu-Fang Chang Yu-Fang Chang Jason Ma Jason Ma Cheng-Hsun Chiu Cheng-Hsun Chiu Cheng-Hsun Chiu Ming-Ling Kuo Ming-Ling Kuo Ming-Ling Kuo Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai |
| author_sort | Yi-Ru Lai |
| collection | DOAJ |
| description | Cytolethal distending toxin (CDT), one of the most important genotoxins, is produced by several gram-negative bacteria and is involved in bacterial pathogenesis. Recent studies have shown that bacteria producing this peculiar genotoxin target host DNA, which potentially contributes to development of cancer. In this review, we highlighted the recent studies focusing on the idea that CDT leads to DNA damage, and the cells with inappropriately repaired DNA continue cycling, resulting in cancer development. Understanding the detailed mechanisms of genotoxins that cause DNA damage might be useful for targeting potential markers that drive cancer progression and help to discover new therapeutic strategies to prevent diseases caused by pathogens. |
| first_indexed | 2024-12-20T18:13:12Z |
| format | Article |
| id | doaj.art-1430b766d95e44a594c09933b2f73277 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T18:13:12Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1430b766d95e44a594c09933b2f732772022-12-21T19:30:25ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-11-011210.3389/fimmu.2021.760451760451From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending ToxinYi-Ru Lai0Yi-Ru Lai1Yu-Fang Chang2Yu-Fang Chang3Jason Ma4Jason Ma5Cheng-Hsun Chiu6Cheng-Hsun Chiu7Cheng-Hsun Chiu8Ming-Ling Kuo9Ming-Ling Kuo10Ming-Ling Kuo11Chih-Ho Lai12Chih-Ho Lai13Chih-Ho Lai14Chih-Ho Lai15Chih-Ho Lai16Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, TaiwanGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, TaiwanGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, TaiwanGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, TaiwanMolecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, TaiwanGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, TaiwanDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, TaiwanGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, TaiwanMolecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, TaiwanDepartment of Microbiology, School of Medicine, China Medical University, Taichung, TaiwanDepartment of Nursing, Asia University, Taichung, TaiwanCytolethal distending toxin (CDT), one of the most important genotoxins, is produced by several gram-negative bacteria and is involved in bacterial pathogenesis. Recent studies have shown that bacteria producing this peculiar genotoxin target host DNA, which potentially contributes to development of cancer. In this review, we highlighted the recent studies focusing on the idea that CDT leads to DNA damage, and the cells with inappropriately repaired DNA continue cycling, resulting in cancer development. Understanding the detailed mechanisms of genotoxins that cause DNA damage might be useful for targeting potential markers that drive cancer progression and help to discover new therapeutic strategies to prevent diseases caused by pathogens.https://www.frontiersin.org/articles/10.3389/fimmu.2021.760451/fullbacterial genotoxincytolethal distending toxinDNA damagegenotoxicitycancer development |
| spellingShingle | Yi-Ru Lai Yi-Ru Lai Yu-Fang Chang Yu-Fang Chang Jason Ma Jason Ma Cheng-Hsun Chiu Cheng-Hsun Chiu Cheng-Hsun Chiu Ming-Ling Kuo Ming-Ling Kuo Ming-Ling Kuo Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin Frontiers in Immunology bacterial genotoxin cytolethal distending toxin DNA damage genotoxicity cancer development |
| title | From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin |
| title_full | From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin |
| title_fullStr | From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin |
| title_full_unstemmed | From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin |
| title_short | From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin |
| title_sort | from dna damage to cancer progression potential effects of cytolethal distending toxin |
| topic | bacterial genotoxin cytolethal distending toxin DNA damage genotoxicity cancer development |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.760451/full |
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