Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved]
The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral. The IL-17R signaling and downstream pathways mediate induction of proinflammatory molecules whic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-05-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/6-741/v1 |
| _version_ | 1818526839702814720 |
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| author | Shibali Das Shabaana Khader |
| author_facet | Shibali Das Shabaana Khader |
| author_sort | Shibali Das |
| collection | DOAJ |
| description | The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral. The IL-17R signaling and downstream pathways mediate induction of proinflammatory molecules which participate in control of these pathogens. However, the production of IL-17 can also mediate pathology and inflammation associated with infections. In this review, we will discuss the yin-and-yang roles of IL-17 in host immunity to pathogens. |
| first_indexed | 2024-12-11T06:28:23Z |
| format | Article |
| id | doaj.art-1430e09dbf004d06a7e174ee25057699 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-11T06:28:23Z |
| publishDate | 2017-05-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-1430e09dbf004d06a7e174ee250576992022-12-22T01:17:35ZengF1000 Research LtdF1000Research2046-14022017-05-01610.12688/f1000research.10862.111712Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved]Shibali Das0Shabaana Khader1Department of Molecular Microbiology, Washington University in St. Louis, St Louis, MO, USADepartment of Molecular Microbiology, Washington University in St. Louis, St Louis, MO, USAThe interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral. The IL-17R signaling and downstream pathways mediate induction of proinflammatory molecules which participate in control of these pathogens. However, the production of IL-17 can also mediate pathology and inflammation associated with infections. In this review, we will discuss the yin-and-yang roles of IL-17 in host immunity to pathogens.https://f1000research.com/articles/6-741/v1Allergy & HypersensitivityAutoimmunityCellular Microbiology & PathogenesisGenetics of the Immune SystemImmune & Inflammatory Rheumatic Diseases (incl. Arthritis)Immune ResponseImmunity to InfectionsImmunomodulationImmunopharmacology & Hematologic PharmacologyInnate ImmunityLeukocyte Signaling & Gene ExpressionMedical MicrobiologyParasitologyVirology |
| spellingShingle | Shibali Das Shabaana Khader Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved] F1000Research Allergy & Hypersensitivity Autoimmunity Cellular Microbiology & Pathogenesis Genetics of the Immune System Immune & Inflammatory Rheumatic Diseases (incl. Arthritis) Immune Response Immunity to Infections Immunomodulation Immunopharmacology & Hematologic Pharmacology Innate Immunity Leukocyte Signaling & Gene Expression Medical Microbiology Parasitology Virology |
| title | Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved] |
| title_full | Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved] |
| title_fullStr | Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved] |
| title_full_unstemmed | Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved] |
| title_short | Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved] |
| title_sort | yin and yang of interleukin 17 in host immunity to infection version 1 referees 2 approved |
| topic | Allergy & Hypersensitivity Autoimmunity Cellular Microbiology & Pathogenesis Genetics of the Immune System Immune & Inflammatory Rheumatic Diseases (incl. Arthritis) Immune Response Immunity to Infections Immunomodulation Immunopharmacology & Hematologic Pharmacology Innate Immunity Leukocyte Signaling & Gene Expression Medical Microbiology Parasitology Virology |
| url | https://f1000research.com/articles/6-741/v1 |
| work_keys_str_mv | AT shibalidas yinandyangofinterleukin17inhostimmunitytoinfectionversion1referees2approved AT shabaanakhader yinandyangofinterleukin17inhostimmunitytoinfectionversion1referees2approved |