Assessment of circulating tumor DNA in cerebrospinal fluid by whole exome sequencing to detect genomic alterations of glioblastoma

Assessment of circulating tumor DNA in cerebrospinal fluid by whole exome sequencing to detect genomic alterations of glioblastoma

Abstract. Background. Cerebrospinal fluid (CSF) has been demonstrated as a better source of circulating tumor DNA (ctDNA) than plasma for brain tumors. However, it is unclear whether whole exome sequencing (WES) is qualified for detection of ctDNA in CSF. The aim of this study was to determine if as...

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Bibliographic Details
Main Authors: Hao Duan, Ji-Long Hu, Zheng-He Chen, Jue-Hui Li, Zhen-Qiang He, Zhen-Ning Wang, Guan-Hua Zhang, Xiao-Yu Guo, Lun Liang, Yong-Gao Mou, Li-Shao Guo
Format: Article
Language:English
Published: Wolters Kluwer 2020-06-01
Series:Chinese Medical Journal
Online Access:http://journals.lww.com/10.1097/CM9.0000000000000843

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