Polymorphism of human haptoglobin and its clinical importance
Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2008-01-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400002 |
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| author | Vânia Peretti de Albuquerque Wobeto Tânia Regina Zaccariotto Maria de Fátima Sonati |
| author_facet | Vânia Peretti de Albuquerque Wobeto Tânia Regina Zaccariotto Maria de Fátima Sonati |
| author_sort | Vânia Peretti de Albuquerque Wobeto |
| collection | DOAJ |
| description | Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders. |
| first_indexed | 2024-12-22T04:44:15Z |
| format | Article |
| id | doaj.art-1431b70490d5407abeb6d31527816112 |
| institution | Directory Open Access Journal |
| issn | 1415-4757 1678-4685 |
| language | English |
| last_indexed | 2024-12-22T04:44:15Z |
| publishDate | 2008-01-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-1431b70490d5407abeb6d315278161122022-12-21T18:38:39ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46852008-01-0131360262010.1590/S1415-47572008000400002Polymorphism of human haptoglobin and its clinical importanceVânia Peretti de Albuquerque WobetoTânia Regina ZaccariottoMaria de Fátima SonatiHaptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400002haptoglobinhemoglobingenetic polymorphisms |
| spellingShingle | Vânia Peretti de Albuquerque Wobeto Tânia Regina Zaccariotto Maria de Fátima Sonati Polymorphism of human haptoglobin and its clinical importance Genetics and Molecular Biology haptoglobin hemoglobin genetic polymorphisms |
| title | Polymorphism of human haptoglobin and its clinical importance |
| title_full | Polymorphism of human haptoglobin and its clinical importance |
| title_fullStr | Polymorphism of human haptoglobin and its clinical importance |
| title_full_unstemmed | Polymorphism of human haptoglobin and its clinical importance |
| title_short | Polymorphism of human haptoglobin and its clinical importance |
| title_sort | polymorphism of human haptoglobin and its clinical importance |
| topic | haptoglobin hemoglobin genetic polymorphisms |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400002 |
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