NRF2 activation suppresses motor neuron ferroptosis induced by the SOD1G93A mutation and exerts neuroprotection in amyotrophic lateral sclerosis

NRF2 activation suppresses motor neuron ferroptosis induced by the SOD1G93A mutation and exerts neuroprotection in amyotrophic lateral sclerosis

The progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS) is caused by a decline in motor neuron function, resulting in worsened motor impairments, malnutrition, respiratory failure and mortality, and there is a lack of effective clinical treatments. The exact mechanism of motor...

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Bibliographic Details
Main Authors: Biying Yang, Jingrui Pan, Xiao-Ni Zhang, Hongxuan Wang, Lei He, Xiaoming Rong, Xiangpen Li, Ying Peng
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Neurobiology of Disease
Subjects:
NRF2
Amyotrophic lateral sclerosis
SOD1G93A
Ferroptosis
Omavleoxolone RTA408
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123002255

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