| Summary: | <p>Abstract</p> <p>Background</p> <p>Most treatment failure of buccal mucosal cancer post surgery is locoregional recurrence. We tried to figure out how close the surgical margin being unsafe and needed further adjuvant treatment.</p> <p>Methods</p> <p>Between August 2000 and June 2008, a total of 110 patients with buccal mucosa carcinoma (25 with stage I, 31 with stage II, 11 with stage III, and 43 with Stage IV classified according to the American Joint Committee on Cancer 6<sup>th </sup>edition) were treated with surgery alone (<it>n </it>= 32), surgery plus postoperative radiotherapy (<it>n </it>= 38) or surgery plus adjuvant concurrent chemoradiotherapy (<it>n </it>= 40).</p> <p>Main outcome measures: The primary endpoint was locoregional disease control.</p> <p>Results</p> <p>The median follow-up time at analysis was 25 months (range, 4-104 months). The 3-year locoregional control rates were significantly different when a 3-mm surgical margin (≤3 <it>versus </it>>3 mm, 71% <it>versus </it>95%, <it>p </it>= 0.04) but not a 5-mm margin (75% <it>versus </it>92%, <it>p </it>= 0.22) was used as the cut-off level. We also found a quantitative correlation between surgical margin and locoregional failure (hazard ratio, 2.16; 95% confidence interval, 1.14 - 4.11; <it>p </it>= 0.019). Multivariate analysis identified pN classification and surgical margin as independent factors affecting disease-free survival and locoregional control.</p> <p>Conclusions</p> <p>Narrow surgical margin ≤3 mm, but not 5 mm, is associated with high risk for locoregional recurrence of buccal mucosa carcinoma. More aggressive treatment after surgery is suggested.</p>
|
|---|