Polyploidy as an Adaptation against Loss of Heterozygosity in Cancer

Polyploidy as an Adaptation against Loss of Heterozygosity in Cancer

Polyploidy is common in cancer cells and has implications for tumor progression and resistance to therapies, but it is unclear whether it is an adaptation of the tumor or the non-adaptive effect of genomic instability. I discuss the possibility that polyploidy reduces the deleterious effects of loss...

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Bibliographic Details
Main Author:	Marco Archetti
Format:	Article
Language:	English
Published:	MDPI AG 2022-08-01
Series:	International Journal of Molecular Sciences
Subjects:	polyploidy heterozygosity complementation endomitosis cancer
Online Access:	https://www.mdpi.com/1422-0067/23/15/8528

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