The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics
An in vivo model is necessary for toxicology. This review analyzed the uses of zebrafish (Danio rerio) in toxicology based on bibliometrics. Totally 56,816 publications about zebrafish from 2002 to 2023 were found in Web of Science Core Collection, with Toxicology as the top 6 among all disciplines....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324000988 |
| _version_ | 1827345375288098816 |
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| author | Weichao Zhao Yuna Chen Nan Hu Dingxin Long Yi Cao |
| author_facet | Weichao Zhao Yuna Chen Nan Hu Dingxin Long Yi Cao |
| author_sort | Weichao Zhao |
| collection | DOAJ |
| description | An in vivo model is necessary for toxicology. This review analyzed the uses of zebrafish (Danio rerio) in toxicology based on bibliometrics. Totally 56,816 publications about zebrafish from 2002 to 2023 were found in Web of Science Core Collection, with Toxicology as the top 6 among all disciplines. Accordingly, the bibliometric map reveals that “toxicity” has become a hot keyword. It further reveals that the most common exposure types include acute, chronic, and combined exposure. The toxicological effects include behavioral, intestinal, cardiovascular, hepatic, endocrine toxicity, neurotoxicity, immunotoxicity, genotoxicity, and reproductive and transgenerational toxicity. The mechanisms include oxidative stress, inflammation, autophagy, and dysbiosis of gut microbiota. The toxicants commonly evaluated by using zebrafish model include nanomaterials, arsenic, metals, bisphenol, and dioxin. Overall, zebrafish provide a unique and well-accepted model to investigate the toxicological effects and mechanisms. We also discussed the possible ways to address some of the limitations of zebrafish model, such as the combination of human organoids to avoid species differences. |
| first_indexed | 2024-03-07T23:06:43Z |
| format | Article |
| id | doaj.art-14344ca865e545d18fc962d3ad102e68 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-07T23:06:43Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-14344ca865e545d18fc962d3ad102e682024-02-22T04:51:23ZengElsevierEcotoxicology and Environmental Safety0147-65132024-03-01272116023The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometricsWeichao Zhao0Yuna Chen1Nan Hu2Dingxin Long3Yi Cao4Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, PR ChinaHunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, PR ChinaKey Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Hengyang 421001, PR China; Corresponding authors.Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, PR China; Corresponding authors.Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, PR China; Corresponding authors.An in vivo model is necessary for toxicology. This review analyzed the uses of zebrafish (Danio rerio) in toxicology based on bibliometrics. Totally 56,816 publications about zebrafish from 2002 to 2023 were found in Web of Science Core Collection, with Toxicology as the top 6 among all disciplines. Accordingly, the bibliometric map reveals that “toxicity” has become a hot keyword. It further reveals that the most common exposure types include acute, chronic, and combined exposure. The toxicological effects include behavioral, intestinal, cardiovascular, hepatic, endocrine toxicity, neurotoxicity, immunotoxicity, genotoxicity, and reproductive and transgenerational toxicity. The mechanisms include oxidative stress, inflammation, autophagy, and dysbiosis of gut microbiota. The toxicants commonly evaluated by using zebrafish model include nanomaterials, arsenic, metals, bisphenol, and dioxin. Overall, zebrafish provide a unique and well-accepted model to investigate the toxicological effects and mechanisms. We also discussed the possible ways to address some of the limitations of zebrafish model, such as the combination of human organoids to avoid species differences.http://www.sciencedirect.com/science/article/pii/S0147651324000988Zebrafish (Danio rerio)Toxicity testsBibliometric analysisEnvironmental pollutantsToxicological mechanism |
| spellingShingle | Weichao Zhao Yuna Chen Nan Hu Dingxin Long Yi Cao The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics Ecotoxicology and Environmental Safety Zebrafish (Danio rerio) Toxicity tests Bibliometric analysis Environmental pollutants Toxicological mechanism |
| title | The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics |
| title_full | The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics |
| title_fullStr | The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics |
| title_full_unstemmed | The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics |
| title_short | The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics |
| title_sort | uses of zebrafish danio rerio as an in vivo model for toxicological studies a review based on bibliometrics |
| topic | Zebrafish (Danio rerio) Toxicity tests Bibliometric analysis Environmental pollutants Toxicological mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324000988 |
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