ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS
The article focuses on aspects of T. gondii reactivation/reinfection in patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). We have observed 297 patients who received conditioning therapy and allogeneic grafts due to different oncohematological or lymphoproliferative d...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Sankt-Peterburg : NIIÈM imeni Pastera
2015-02-01
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| Series: | Инфекция и иммунитет |
| Subjects: | |
| Online Access: | https://www.iimmun.ru/iimm/article/view/250 |
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| author | A. B. Chukhlovin L. S. Zubarovskaya S. N. Bondarenko Yu. A. Eismont A. V. Semenov M. D. Vladovskaya Areg A. Totolian B. V. Afanasyev |
| author_facet | A. B. Chukhlovin L. S. Zubarovskaya S. N. Bondarenko Yu. A. Eismont A. V. Semenov M. D. Vladovskaya Areg A. Totolian B. V. Afanasyev |
| author_sort | A. B. Chukhlovin |
| collection | DOAJ |
| description | The article focuses on aspects of T. gondii reactivation/reinfection in patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). We have observed 297 patients who received conditioning therapy and allogeneic grafts due to different oncohematological or lymphoproliferative diseases (1 to 60 years old, at a mediane of 19 years). Conditioning regimens were either myeloablative (35%), or non-myeloablative (65%). DNA diagnostics of T. gondii was performed on a regular basis at 0 to 6 months post-HSCT. IgG and IgM antibodies against T. gondii were determined in 78 patients before HSCT, as well as in their donors. T. gondii DNA post-transplant proved to be positive in 13% of blood specimens, 9% of cerebrospinal liquor samples, 11% of bronchoalveolar cell lavages, and in 5% of urine sediments. In adolescent patients (10 to 14 years old), an increased prevalence of T. gondii was found in patients who received myeloablative treatment (p = 0.01). When assessing posttransplant dynamics of T. gondii, we have revealed distinct increase in the pathogen excretion within 1st month after HSCT (p = 0.03). Finally, initial presence of IgG antibodies against T. gondii in the patients was associated with lower incidence of the pathogen reactivation post-transplant. |
| first_indexed | 2024-04-11T02:37:27Z |
| format | Article |
| id | doaj.art-1434dd6499444942a9a35bdd0d2972bc |
| institution | Directory Open Access Journal |
| issn | 2220-7619 2313-7398 |
| language | Russian |
| last_indexed | 2024-04-11T02:37:27Z |
| publishDate | 2015-02-01 |
| publisher | Sankt-Peterburg : NIIÈM imeni Pastera |
| record_format | Article |
| series | Инфекция и иммунитет |
| spelling | doaj.art-1434dd6499444942a9a35bdd0d2972bc2023-01-02T19:35:51ZrusSankt-Peterburg : NIIÈM imeni PasteraИнфекция и иммунитет2220-76192313-73982015-02-014438138610.15789/2220-7619-2014-4-381-386199ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTSA. B. Chukhlovin0L. S. Zubarovskaya1S. N. Bondarenko2Yu. A. Eismont3A. V. Semenov4M. D. Vladovskaya5Areg A. Totolian6B. V. Afanasyev7R. Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantology, Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia 197089, Russian Federation, St. Petersburg, L. Tolstoy str., 6/8, R. Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantology, Pavlov First St. Petersburg State Medical University. Phone/fax: +7 (812) 499-70-79R. Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantology, Pavlov First St. Petersburg State Medical University, St. Petersburg, RussiaR. Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantology, Pavlov First St. Petersburg State Medical University, St. Petersburg, RussiaR. Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantology, Pavlov First St. Petersburg State Medical University, St. Petersburg, RussiaSt. Petersburg Pasteur Institute, St. Petersburg, RussiaR. Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantology, Pavlov First St. Petersburg State Medical University, St. Petersburg, RussiaSt. Petersburg Pasteur Institute, St. Petersburg, RussiaR. Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantology, Pavlov First St. Petersburg State Medical University, St. Petersburg, RussiaThe article focuses on aspects of T. gondii reactivation/reinfection in patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). We have observed 297 patients who received conditioning therapy and allogeneic grafts due to different oncohematological or lymphoproliferative diseases (1 to 60 years old, at a mediane of 19 years). Conditioning regimens were either myeloablative (35%), or non-myeloablative (65%). DNA diagnostics of T. gondii was performed on a regular basis at 0 to 6 months post-HSCT. IgG and IgM antibodies against T. gondii were determined in 78 patients before HSCT, as well as in their donors. T. gondii DNA post-transplant proved to be positive in 13% of blood specimens, 9% of cerebrospinal liquor samples, 11% of bronchoalveolar cell lavages, and in 5% of urine sediments. In adolescent patients (10 to 14 years old), an increased prevalence of T. gondii was found in patients who received myeloablative treatment (p = 0.01). When assessing posttransplant dynamics of T. gondii, we have revealed distinct increase in the pathogen excretion within 1st month after HSCT (p = 0.03). Finally, initial presence of IgG antibodies against T. gondii in the patients was associated with lower incidence of the pathogen reactivation post-transplant.https://www.iimmun.ru/iimm/article/view/250hematopoietic stem cell transplantationtoxoplasma gondiireactivationdna diagnosticsigg antibodies |
| spellingShingle | A. B. Chukhlovin L. S. Zubarovskaya S. N. Bondarenko Yu. A. Eismont A. V. Semenov M. D. Vladovskaya Areg A. Totolian B. V. Afanasyev ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS Инфекция и иммунитет hematopoietic stem cell transplantation toxoplasma gondii reactivation dna diagnostics igg antibodies |
| title | ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS |
| title_full | ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS |
| title_fullStr | ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS |
| title_full_unstemmed | ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS |
| title_short | ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS |
| title_sort | activation of t gondii infection after allogeneic transplantation of hematopoietic stem cells dependence on time of transplantation and serological status of the patients |
| topic | hematopoietic stem cell transplantation toxoplasma gondii reactivation dna diagnostics igg antibodies |
| url | https://www.iimmun.ru/iimm/article/view/250 |
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