Differential Lipidomic Characteristics of Children Born to Women with Polycystic Ovary Syndrome
ObjectiveTo describe the lipidomic characteristics of offspring born to polycystic ovary syndrome (PCOS) women (PCOS-off) and assess the associations between differential lipids and clinical phenotypes.MethodsUltra performance liquid chromatography and mass spectrometry were performed on plasma samp...
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.698734/full |
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| author | Zhirong Zhang Zhirong Zhang Zhirong Zhang Zhirong Zhang Zhirong Zhang Yue Liu Yue Liu Yue Liu Yue Liu Yue Liu Jiali Lv Di Zhang Di Zhang Di Zhang Di Zhang Di Zhang Kuona Hu Kuona Hu Kuona Hu Kuona Hu Kuona Hu Jingyu Li Jingyu Li Jingyu Li Jingyu Li Jingyu Li Jinlong Ma Jinlong Ma Jinlong Ma Jinlong Ma Jinlong Ma Linlin Cui Linlin Cui Linlin Cui Linlin Cui Linlin Cui Han Zhao Han Zhao Han Zhao Han Zhao Han Zhao |
| author_facet | Zhirong Zhang Zhirong Zhang Zhirong Zhang Zhirong Zhang Zhirong Zhang Yue Liu Yue Liu Yue Liu Yue Liu Yue Liu Jiali Lv Di Zhang Di Zhang Di Zhang Di Zhang Di Zhang Kuona Hu Kuona Hu Kuona Hu Kuona Hu Kuona Hu Jingyu Li Jingyu Li Jingyu Li Jingyu Li Jingyu Li Jinlong Ma Jinlong Ma Jinlong Ma Jinlong Ma Jinlong Ma Linlin Cui Linlin Cui Linlin Cui Linlin Cui Linlin Cui Han Zhao Han Zhao Han Zhao Han Zhao Han Zhao |
| author_sort | Zhirong Zhang |
| collection | DOAJ |
| description | ObjectiveTo describe the lipidomic characteristics of offspring born to polycystic ovary syndrome (PCOS) women (PCOS-off) and assess the associations between differential lipids and clinical phenotypes.MethodsUltra performance liquid chromatography and mass spectrometry were performed on plasma samples from 70 PCOS-off and 71 healthy controls. The associations of differential metabolites with clinical phenotypes were examined by multiple linear regression.ResultsForty-four metabolites were significantly altered in PCOS-off, including 8 increased and 36 decreased. After stratification according to sex, 44 metabolites (13 increased and 31 decreased) were expressed differently in girls born to PCOS women (PCOS-g), most of which were glycerolipids. Furthermore, 46 metabolites (9 increased and 35 decreased) were expressed differently in boys born to PCOS women (PCOS-b), most of which were glycerophospholipids. Significant associations of metabolites with weight Z-score and high density lipoprotein cholesterol were found in PCOS-off. Triglycerides, low density lipoprotein cholesterol, and thyroid-stimulating hormone were separately correlated with some lipids in PCOS-g and PCOS-b.ConclusionsPCOS-off showed specific lipid profile alterations. The abnormal level of glycerophospholipids and sphingomyelin indicated the risk of glucose metabolism and cardiovascular diseases in PCOS-off. Some lipids, such as phosphatidylcholines, lysophosphatidylcholine and sphingomyelin, may be the potential markers. The results broadened our understanding of PCOS-offs’ cardiometabolic status and emphasized more specific and detailed monitoring and management in this population. |
| first_indexed | 2024-12-14T22:30:14Z |
| format | Article |
| id | doaj.art-143805be49a5415da05afe9b5c82cf5d |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-14T22:30:14Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-143805be49a5415da05afe9b5c82cf5d2022-12-21T22:45:16ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-08-011210.3389/fendo.2021.698734698734Differential Lipidomic Characteristics of Children Born to Women with Polycystic Ovary SyndromeZhirong Zhang0Zhirong Zhang1Zhirong Zhang2Zhirong Zhang3Zhirong Zhang4Yue Liu5Yue Liu6Yue Liu7Yue Liu8Yue Liu9Jiali Lv10Di Zhang11Di Zhang12Di Zhang13Di Zhang14Di Zhang15Kuona Hu16Kuona Hu17Kuona Hu18Kuona Hu19Kuona Hu20Jingyu Li21Jingyu Li22Jingyu Li23Jingyu Li24Jingyu Li25Jinlong Ma26Jinlong Ma27Jinlong Ma28Jinlong Ma29Jinlong Ma30Linlin Cui31Linlin Cui32Linlin Cui33Linlin Cui34Linlin Cui35Han Zhao36Han Zhao37Han Zhao38Han Zhao39Han Zhao40Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKey laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, ChinaShandong Key Laboratory of Reproductive Medicine, Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Shandong University, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, ChinaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKey laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, ChinaShandong Key Laboratory of Reproductive Medicine, Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Shandong University, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, ChinaDepartment of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, ChinaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKey laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, ChinaShandong Key Laboratory of Reproductive Medicine, Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Shandong University, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, ChinaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKey laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, ChinaShandong Key Laboratory of Reproductive Medicine, Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Shandong University, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, ChinaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKey laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, ChinaShandong Key Laboratory of Reproductive Medicine, Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Shandong University, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, ChinaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKey laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, ChinaShandong Key Laboratory of Reproductive Medicine, Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Shandong University, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, ChinaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKey laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, ChinaShandong Key Laboratory of Reproductive Medicine, Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Shandong University, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, ChinaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKey laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, ChinaShandong Key Laboratory of Reproductive Medicine, Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Shandong University, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, ChinaObjectiveTo describe the lipidomic characteristics of offspring born to polycystic ovary syndrome (PCOS) women (PCOS-off) and assess the associations between differential lipids and clinical phenotypes.MethodsUltra performance liquid chromatography and mass spectrometry were performed on plasma samples from 70 PCOS-off and 71 healthy controls. The associations of differential metabolites with clinical phenotypes were examined by multiple linear regression.ResultsForty-four metabolites were significantly altered in PCOS-off, including 8 increased and 36 decreased. After stratification according to sex, 44 metabolites (13 increased and 31 decreased) were expressed differently in girls born to PCOS women (PCOS-g), most of which were glycerolipids. Furthermore, 46 metabolites (9 increased and 35 decreased) were expressed differently in boys born to PCOS women (PCOS-b), most of which were glycerophospholipids. Significant associations of metabolites with weight Z-score and high density lipoprotein cholesterol were found in PCOS-off. Triglycerides, low density lipoprotein cholesterol, and thyroid-stimulating hormone were separately correlated with some lipids in PCOS-g and PCOS-b.ConclusionsPCOS-off showed specific lipid profile alterations. The abnormal level of glycerophospholipids and sphingomyelin indicated the risk of glucose metabolism and cardiovascular diseases in PCOS-off. Some lipids, such as phosphatidylcholines, lysophosphatidylcholine and sphingomyelin, may be the potential markers. The results broadened our understanding of PCOS-offs’ cardiometabolic status and emphasized more specific and detailed monitoring and management in this population.https://www.frontiersin.org/articles/10.3389/fendo.2021.698734/fulllipid metabolismlipidomicspolycystic ovary syndromeoffspringcardiometabolic health |
| spellingShingle | Zhirong Zhang Zhirong Zhang Zhirong Zhang Zhirong Zhang Zhirong Zhang Yue Liu Yue Liu Yue Liu Yue Liu Yue Liu Jiali Lv Di Zhang Di Zhang Di Zhang Di Zhang Di Zhang Kuona Hu Kuona Hu Kuona Hu Kuona Hu Kuona Hu Jingyu Li Jingyu Li Jingyu Li Jingyu Li Jingyu Li Jinlong Ma Jinlong Ma Jinlong Ma Jinlong Ma Jinlong Ma Linlin Cui Linlin Cui Linlin Cui Linlin Cui Linlin Cui Han Zhao Han Zhao Han Zhao Han Zhao Han Zhao Differential Lipidomic Characteristics of Children Born to Women with Polycystic Ovary Syndrome Frontiers in Endocrinology lipid metabolism lipidomics polycystic ovary syndrome offspring cardiometabolic health |
| title | Differential Lipidomic Characteristics of Children Born to Women with Polycystic Ovary Syndrome |
| title_full | Differential Lipidomic Characteristics of Children Born to Women with Polycystic Ovary Syndrome |
| title_fullStr | Differential Lipidomic Characteristics of Children Born to Women with Polycystic Ovary Syndrome |
| title_full_unstemmed | Differential Lipidomic Characteristics of Children Born to Women with Polycystic Ovary Syndrome |
| title_short | Differential Lipidomic Characteristics of Children Born to Women with Polycystic Ovary Syndrome |
| title_sort | differential lipidomic characteristics of children born to women with polycystic ovary syndrome |
| topic | lipid metabolism lipidomics polycystic ovary syndrome offspring cardiometabolic health |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.698734/full |
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