Biomimetic Design for a Dual Concentric Porous Titanium Scaffold with Appropriate Compressive Strength and Cells Affinity
In repairing or replacing damaged bones, a dual concentric porous titanium scaffold (P-Ti<sub>x-y</sub>) has emerged as a promising bio-mimic design. Herein, various P-Ti<sub>x-y</sub> were made and sintered with relatively dense (x = 10, 20, or 30% porosity) and loose (y = 4...
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MDPI AG
2020-07-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/13/15/3316 |
| _version_ | 1797561349117575168 |
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| author | Han Lee Jiunn-Der Liao Yao-Sheng Guo Yung-Der Juang |
| author_facet | Han Lee Jiunn-Der Liao Yao-Sheng Guo Yung-Der Juang |
| author_sort | Han Lee |
| collection | DOAJ |
| description | In repairing or replacing damaged bones, a dual concentric porous titanium scaffold (P-Ti<sub>x-y</sub>) has emerged as a promising bio-mimic design. Herein, various P-Ti<sub>x-y</sub> were made and sintered with relatively dense (x = 10, 20, or 30% porosity) and loose (y = 45, 55, or 65 porosity) structures. Firstly, NaCl was used as the pore-forming additive and followed by a hydrothermal removal method. The compressive strength of the as-formed P-Ti<sub>x_y</sub> and surface morphology, nanomechanical property, and cells’ affinity on the cross-sectioned surface of P-Ti<sub>x_y</sub> (CP-Ti<sub>x_y</sub>) were then characterized. The results demonstrate that the compressive strength of P-Ti<sub>10_45</sub>, P-Ti<sub>20_45</sub>, or P-Ti<sub>20_55</sub> exhibits a relatively mild decline (e.g., in the range of 181 and 97 MPa, higher than the required value of 70 MPa) and suitable porosities for the intended structure. Nano-hardness on the solid surface of CP-Ti<sub>x_y</sub> shows roughly consistent with that of CP-Ti (i.e., ~8.78 GPa), thus, the porous structure of CP-Ti<sub>x_y</sub> remains mostly unaffected by the addition of NaCl and subsequent sintering process. Most of the surfaces of CP-Ti<sub>x_y</sub> exhibit high fibroblast (L929) cell affinity with low cell mortality. Notably, in the hFOB 1.19 cell adhesion and proliferation test, CP-Ti<sub>20_55</sub> and CP-Ti<sub>20_65</sub> reveal high cell viability, most probably relating with the assembly of dual porosities with interconnected pores. Overall, the sample P-Ti<sub>20_55</sub> provides a relatively load-bearable design with high cell affinity and is thus promising as a three-dimensional bio-scaffold. |
| first_indexed | 2024-03-10T18:12:41Z |
| format | Article |
| id | doaj.art-14383919da04404a9f89de72dde8a0d7 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T18:12:41Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-14383919da04404a9f89de72dde8a0d72023-11-20T07:55:57ZengMDPI AGMaterials1996-19442020-07-011315331610.3390/ma13153316Biomimetic Design for a Dual Concentric Porous Titanium Scaffold with Appropriate Compressive Strength and Cells AffinityHan Lee0Jiunn-Der Liao1Yao-Sheng Guo2Yung-Der Juang3Department of Materials Science and Engineering, National Cheng Kung University, 1 University Road, Tainan 701, TaiwanDepartment of Materials Science and Engineering, National Cheng Kung University, 1 University Road, Tainan 701, TaiwanDepartment of Materials Science and Engineering, National Cheng Kung University, 1 University Road, Tainan 701, TaiwanDepartment of Materials Science, National University of Tainan, Tainan 700, TaiwanIn repairing or replacing damaged bones, a dual concentric porous titanium scaffold (P-Ti<sub>x-y</sub>) has emerged as a promising bio-mimic design. Herein, various P-Ti<sub>x-y</sub> were made and sintered with relatively dense (x = 10, 20, or 30% porosity) and loose (y = 45, 55, or 65 porosity) structures. Firstly, NaCl was used as the pore-forming additive and followed by a hydrothermal removal method. The compressive strength of the as-formed P-Ti<sub>x_y</sub> and surface morphology, nanomechanical property, and cells’ affinity on the cross-sectioned surface of P-Ti<sub>x_y</sub> (CP-Ti<sub>x_y</sub>) were then characterized. The results demonstrate that the compressive strength of P-Ti<sub>10_45</sub>, P-Ti<sub>20_45</sub>, or P-Ti<sub>20_55</sub> exhibits a relatively mild decline (e.g., in the range of 181 and 97 MPa, higher than the required value of 70 MPa) and suitable porosities for the intended structure. Nano-hardness on the solid surface of CP-Ti<sub>x_y</sub> shows roughly consistent with that of CP-Ti (i.e., ~8.78 GPa), thus, the porous structure of CP-Ti<sub>x_y</sub> remains mostly unaffected by the addition of NaCl and subsequent sintering process. Most of the surfaces of CP-Ti<sub>x_y</sub> exhibit high fibroblast (L929) cell affinity with low cell mortality. Notably, in the hFOB 1.19 cell adhesion and proliferation test, CP-Ti<sub>20_55</sub> and CP-Ti<sub>20_65</sub> reveal high cell viability, most probably relating with the assembly of dual porosities with interconnected pores. Overall, the sample P-Ti<sub>20_55</sub> provides a relatively load-bearable design with high cell affinity and is thus promising as a three-dimensional bio-scaffold.https://www.mdpi.com/1996-1944/13/15/3316dual concentric poroustitanium scaffoldbio-mimic designload-bearablecell affinity |
| spellingShingle | Han Lee Jiunn-Der Liao Yao-Sheng Guo Yung-Der Juang Biomimetic Design for a Dual Concentric Porous Titanium Scaffold with Appropriate Compressive Strength and Cells Affinity Materials dual concentric porous titanium scaffold bio-mimic design load-bearable cell affinity |
| title | Biomimetic Design for a Dual Concentric Porous Titanium Scaffold with Appropriate Compressive Strength and Cells Affinity |
| title_full | Biomimetic Design for a Dual Concentric Porous Titanium Scaffold with Appropriate Compressive Strength and Cells Affinity |
| title_fullStr | Biomimetic Design for a Dual Concentric Porous Titanium Scaffold with Appropriate Compressive Strength and Cells Affinity |
| title_full_unstemmed | Biomimetic Design for a Dual Concentric Porous Titanium Scaffold with Appropriate Compressive Strength and Cells Affinity |
| title_short | Biomimetic Design for a Dual Concentric Porous Titanium Scaffold with Appropriate Compressive Strength and Cells Affinity |
| title_sort | biomimetic design for a dual concentric porous titanium scaffold with appropriate compressive strength and cells affinity |
| topic | dual concentric porous titanium scaffold bio-mimic design load-bearable cell affinity |
| url | https://www.mdpi.com/1996-1944/13/15/3316 |
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