Antifibrotic effects of crocetin in scleroderma fibroblasts and in bleomycin-induced sclerotic mice

Antifibrotic effects of crocetin in scleroderma fibroblasts and in bleomycin-induced sclerotic mice

OBJECTIVE: To investigate the antifibrotic effects of crocetin in scleroderma fibroblasts and in sclerotic mice. METHODS: Skin fibroblasts that were isolated from three systemic scleroderma (SSc) patients and three healthy subjects were treated with crocetin (0.1, 1 or 10 μM). Cell proliferation w...

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Bibliographic Details
Main Authors: Yinghua Song, Lubing Zhu, Ming Li
Format: Article
Language:English
Published: Elsevier España 2013-10-01
Series:Clinics
Subjects:
Crocetin
Fibroblasts
Systemic scleroderma
Collagen
Fibrosis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013001001350&lng=en&tlng=en

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