Hypoglycemic Effect of Resveratrol: A Systematic Review and Meta-Analysis
Resveratrol (RV) is a polyphenolic compound with antioxidant, anti-inflammatory, and hypoglycemic properties. Several in vitro and animal model studies have demonstrated the beneficial effects of RV; however, the results in humans are not conclusive. After a search of different databases, 32 studies...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/10/1/69 |
| _version_ | 1797415157604810752 |
|---|---|
| author | Beatriz Isabel García-Martínez Mirna Ruiz-Ramos José Pedraza-Chaverri Edelmiro Santiago-Osorio Víctor Manuel Mendoza-Núñez |
| author_facet | Beatriz Isabel García-Martínez Mirna Ruiz-Ramos José Pedraza-Chaverri Edelmiro Santiago-Osorio Víctor Manuel Mendoza-Núñez |
| author_sort | Beatriz Isabel García-Martínez |
| collection | DOAJ |
| description | Resveratrol (RV) is a polyphenolic compound with antioxidant, anti-inflammatory, and hypoglycemic properties. Several in vitro and animal model studies have demonstrated the beneficial effects of RV; however, the results in humans are not conclusive. After a search of different databases, 32 studies were selected for this systematic review and 30 were included in the meta-analysis. Studies that evaluated the effect of RV on glucose, insulin, HbA1c, and insulin resistance (HOMA-IR) levels were included. A significant decrease of glucose (−5.24 mg/dL, <i>p</i> = 0.002) and insulin levels (−1.23 mIU/L, <i>p</i> = 0.0003) was observed. HbA1c and HOMA-IR did not show significant changes. Due to heterogeneity, sub-analyzes were performed. Sub-analysis by dose revealed that glucose levels improve significantly after the administration of 500–1000 mg/day of RV (−7.54 mg/dL, <i>p</i> = 0.002), while insulin improves with doses lower than 500 mg/day (−1.43 mIU/L, <i>p</i> = 0.01) and greater than 1000 mg/day (−2.12 mIU/L, <i>p</i> = 0.03). HbA1c and HOMA-IR remained unchanged after sub-analysis by dose. Our findings suggest that RV improves glucose and insulin levels in subjects with type 2 diabetes mellitus (T2DM) and aged 45–59 years, regardless of the duration of the intervention. HbA1c improves with interventions ≥3 months. HOMA-IR does not exhibit significant changes after RV administration. |
| first_indexed | 2024-03-09T05:44:46Z |
| format | Article |
| id | doaj.art-143acc9080c54727908b62f45f8671e3 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T05:44:46Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-143acc9080c54727908b62f45f8671e32023-12-03T12:22:10ZengMDPI AGAntioxidants2076-39212021-01-011016910.3390/antiox10010069Hypoglycemic Effect of Resveratrol: A Systematic Review and Meta-AnalysisBeatriz Isabel García-Martínez0Mirna Ruiz-Ramos1José Pedraza-Chaverri2Edelmiro Santiago-Osorio3Víctor Manuel Mendoza-Núñez4Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, MexicoResearch Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, MexicoDepartment of Biology, Faculty of Chemistry, National Autonomous University of Mexico (UNAM), Mexico City 04510, MexicoHematopoiesis and Leukemia Laboratory, Research Unit on Cell Differentiation and Cancer, FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, MexicoResearch Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, MexicoResveratrol (RV) is a polyphenolic compound with antioxidant, anti-inflammatory, and hypoglycemic properties. Several in vitro and animal model studies have demonstrated the beneficial effects of RV; however, the results in humans are not conclusive. After a search of different databases, 32 studies were selected for this systematic review and 30 were included in the meta-analysis. Studies that evaluated the effect of RV on glucose, insulin, HbA1c, and insulin resistance (HOMA-IR) levels were included. A significant decrease of glucose (−5.24 mg/dL, <i>p</i> = 0.002) and insulin levels (−1.23 mIU/L, <i>p</i> = 0.0003) was observed. HbA1c and HOMA-IR did not show significant changes. Due to heterogeneity, sub-analyzes were performed. Sub-analysis by dose revealed that glucose levels improve significantly after the administration of 500–1000 mg/day of RV (−7.54 mg/dL, <i>p</i> = 0.002), while insulin improves with doses lower than 500 mg/day (−1.43 mIU/L, <i>p</i> = 0.01) and greater than 1000 mg/day (−2.12 mIU/L, <i>p</i> = 0.03). HbA1c and HOMA-IR remained unchanged after sub-analysis by dose. Our findings suggest that RV improves glucose and insulin levels in subjects with type 2 diabetes mellitus (T2DM) and aged 45–59 years, regardless of the duration of the intervention. HbA1c improves with interventions ≥3 months. HOMA-IR does not exhibit significant changes after RV administration.https://www.mdpi.com/2076-3921/10/1/69glucoseinsulinglycated hemoglobinglycemic controlinsulin resistancepolyphenolic compounds |
| spellingShingle | Beatriz Isabel García-Martínez Mirna Ruiz-Ramos José Pedraza-Chaverri Edelmiro Santiago-Osorio Víctor Manuel Mendoza-Núñez Hypoglycemic Effect of Resveratrol: A Systematic Review and Meta-Analysis Antioxidants glucose insulin glycated hemoglobin glycemic control insulin resistance polyphenolic compounds |
| title | Hypoglycemic Effect of Resveratrol: A Systematic Review and Meta-Analysis |
| title_full | Hypoglycemic Effect of Resveratrol: A Systematic Review and Meta-Analysis |
| title_fullStr | Hypoglycemic Effect of Resveratrol: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Hypoglycemic Effect of Resveratrol: A Systematic Review and Meta-Analysis |
| title_short | Hypoglycemic Effect of Resveratrol: A Systematic Review and Meta-Analysis |
| title_sort | hypoglycemic effect of resveratrol a systematic review and meta analysis |
| topic | glucose insulin glycated hemoglobin glycemic control insulin resistance polyphenolic compounds |
| url | https://www.mdpi.com/2076-3921/10/1/69 |
| work_keys_str_mv | AT beatrizisabelgarciamartinez hypoglycemiceffectofresveratrolasystematicreviewandmetaanalysis AT mirnaruizramos hypoglycemiceffectofresveratrolasystematicreviewandmetaanalysis AT josepedrazachaverri hypoglycemiceffectofresveratrolasystematicreviewandmetaanalysis AT edelmirosantiagoosorio hypoglycemiceffectofresveratrolasystematicreviewandmetaanalysis AT victormanuelmendozanunez hypoglycemiceffectofresveratrolasystematicreviewandmetaanalysis |