Effect of sucralose on the blood content of thyroid hormones
Sugar substitutes are among the most widely used food additives. Increasing number of scientific research on their adverse effect on various body functions has been appearing lately. The objective of this research is to study the effect of sucralose, a sugar substitute, on the thyroid functional sta...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2020-10-01
|
| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2020/11/Oliynyk_5_20.pdf |
| _version_ | 1827613707160518656 |
|---|---|
| author | O. Oliynyk A. Slifirczyk Y. Oliynyk B. Pereviznyk |
| author_facet | O. Oliynyk A. Slifirczyk Y. Oliynyk B. Pereviznyk |
| author_sort | O. Oliynyk |
| collection | DOAJ |
| description | Sugar substitutes are among the most widely used food additives. Increasing number of scientific research on their adverse effect on various body functions has been appearing lately. The objective of this research is to study the effect of sucralose, a sugar substitute, on the thyroid functional state. Involved in the research were 30 women, aged 19-28, estimating themselves healthy. The blood content of free and general triiodothyronine, free and general thyroxine, as well as of thyrotropic hormone was determined. Thereafter, the women were taking sucralose for a month daily in a dose of 15 mg/kg, the blood content of the hormones mentioned above having been tested again. Reliable 2.0, 1.58, and 1.46 times decrease in the blood content of free and general triiodothyronine, and general thyroxine, respectively, as well as reliable 4.41 times increase in the blood content of thyrotropic hormone (Р < 0.001) has been found. Our findings on the sucralose-induced decrease in the level of thyroid hormones confirm the results of other researchers regarding sucralose as biologically inert compound that should be kept in mind when evaluating its effect on the patients with endocrine pathology. |
| first_indexed | 2024-03-09T08:43:35Z |
| format | Article |
| id | doaj.art-143acd9fc8b847f39d2ecece80fc991a |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T08:43:35Z |
| publishDate | 2020-10-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-143acd9fc8b847f39d2ecece80fc991a2023-12-02T15:44:21ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032020-10-0192510611010.15407/ubj92.05.106Effect of sucralose on the blood content of thyroid hormonesO. Oliynyk0https://orcid.org/0000-0003-2886-7741A. Slifirczyk1https://orcid.org/0000-0002-2495-025X Y. Oliynyk2B. Pereviznyk3https://orcid.org/0000-0002-8302-4061Pope John Paul II State School of Higher Education, Biała Podlaska, Poland; Bogomolets National Medical University, Kyiv, UkrainePope John Paul II State School of Higher Education, Biała Podlaska, PolandI. Horbachevsky Ternopil National Medical University, UkraineI. Horbachevsky Ternopil National Medical University, UkraineSugar substitutes are among the most widely used food additives. Increasing number of scientific research on their adverse effect on various body functions has been appearing lately. The objective of this research is to study the effect of sucralose, a sugar substitute, on the thyroid functional state. Involved in the research were 30 women, aged 19-28, estimating themselves healthy. The blood content of free and general triiodothyronine, free and general thyroxine, as well as of thyrotropic hormone was determined. Thereafter, the women were taking sucralose for a month daily in a dose of 15 mg/kg, the blood content of the hormones mentioned above having been tested again. Reliable 2.0, 1.58, and 1.46 times decrease in the blood content of free and general triiodothyronine, and general thyroxine, respectively, as well as reliable 4.41 times increase in the blood content of thyrotropic hormone (Р < 0.001) has been found. Our findings on the sucralose-induced decrease in the level of thyroid hormones confirm the results of other researchers regarding sucralose as biologically inert compound that should be kept in mind when evaluating its effect on the patients with endocrine pathology.http://ukrbiochemjournal.org/wp-content/uploads/2020/11/Oliynyk_5_20.pdfthyroid hormonessucralose introduction |
| spellingShingle | O. Oliynyk A. Slifirczyk Y. Oliynyk B. Pereviznyk Effect of sucralose on the blood content of thyroid hormones The Ukrainian Biochemical Journal thyroid hormones sucralose introduction |
| title | Effect of sucralose on the blood content of thyroid hormones |
| title_full | Effect of sucralose on the blood content of thyroid hormones |
| title_fullStr | Effect of sucralose on the blood content of thyroid hormones |
| title_full_unstemmed | Effect of sucralose on the blood content of thyroid hormones |
| title_short | Effect of sucralose on the blood content of thyroid hormones |
| title_sort | effect of sucralose on the blood content of thyroid hormones |
| topic | thyroid hormones sucralose introduction |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2020/11/Oliynyk_5_20.pdf |
| work_keys_str_mv | AT ooliynyk effectofsucraloseonthebloodcontentofthyroidhormones AT aslifirczyk effectofsucraloseonthebloodcontentofthyroidhormones AT yoliynyk effectofsucraloseonthebloodcontentofthyroidhormones AT bpereviznyk effectofsucraloseonthebloodcontentofthyroidhormones |