Efficacy and Safety of Transarterial Chemoembolization for the Treatment of Unresectable Hepatocellular Carcinoma Associated with Bile Duct Tumor Thrombus: A Real-World Retrospective Cohort Study
Jin-Kai Feng,1,* Ju-Xian Sun,1,* Zong-Han Liu,1,* Jing-Wen Gu,2,* Zhen-Hua Chen,3 Chang Liu,1 Wei-Xing Guo,1 Jie Shi,1 Shu-Qun Cheng1 1Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, People’s Republic of China; 2Colleg...
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Dove Medical Press
2021-04-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/efficacy-and-safety-of-transarterial-chemoembolization-for-the-treatme-peer-reviewed-fulltext-article-CMAR |
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| author | Feng JK Sun JX Liu ZH Gu JW Chen ZH Liu C Guo WX Shi J Cheng SQ |
| author_facet | Feng JK Sun JX Liu ZH Gu JW Chen ZH Liu C Guo WX Shi J Cheng SQ |
| author_sort | Feng JK |
| collection | DOAJ |
| description | Jin-Kai Feng,1,* Ju-Xian Sun,1,* Zong-Han Liu,1,* Jing-Wen Gu,2,* Zhen-Hua Chen,3 Chang Liu,1 Wei-Xing Guo,1 Jie Shi,1 Shu-Qun Cheng1 1Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, People’s Republic of China; 2College of Basic Medical Sciences, Second Military Medical University, Shanghai, People’s Republic of China; 3Department of General Surgery, Zhejiang Provincial Armed Police Corps Hospital, Hangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shu-Qun ChengDepartment of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, Shanghai, 200433, People’s Republic of ChinaTel +86 21- 81875251Fax +86 21- 65562400Email chengshuqun@aliyun.comBackground: The occurrence of hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) is rare. The aim of the study was to evaluate the effectiveness and safety of transarterial chemoembolization (TACE) for patients with unresectable HCC with BDTT.Methods: This retrospective study was conducted on newly diagnosed HCC and BDTT patients who were initially treated with TACE or conservative management (CM) from 2009 to 2018. Survival outcomes of patients treated with TACE were compared with those of patients given CM. Multivariate analyses were performed to identify independent prognostic factors related to survival.Results: Out of 100 patients included in this study, 40 patients underwent TACE, while the remaining 60 received CM. The median survival time of the TACE group was 8.0 months longer than that of the CM group (13.0 versus 5.0 months, P < 0.001). The 6-, 12-, 18-, 24-month overall survival (OS) rates were 90.0%, 52.5%, 22.5%, and 12.5%, respectively, for the TACE group compared with 26.7%, 8.3%, 5.0%, and 3.3%, respectively, for the CM group. Multivariate analyses showed that treatment allocation (hazard ratio [HR], 0.421; 95% confidence interval [CI], 0.243– 0.730; P = 0.002), Child–Pugh status (HR, 2.529; 95% CI, 1.300– 4.920; P = 0.006) and total bilirubin level (HR, 1.007; 95% CI, 1.004– 1.009; P < 0.001) on first admission were independent predictors of OS. There was no procedure-related mortality within one month after TACE treatment.Conclusion: TACE is a safe and effective treatment method that may improve the OS of patients with unresectable HCC with BDTT.Keywords: hepatocellular carcinoma, bile duct tumor thrombus, transarterial chemoembolization, conservative management, overall survival |
| first_indexed | 2024-12-17T00:32:02Z |
| format | Article |
| id | doaj.art-143b0713371540bf9be8b68329a96b61 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-17T00:32:02Z |
| publishDate | 2021-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-143b0713371540bf9be8b68329a96b612022-12-21T22:10:16ZengDove Medical PressCancer Management and Research1179-13222021-04-01Volume 133551356064277Efficacy and Safety of Transarterial Chemoembolization for the Treatment of Unresectable Hepatocellular Carcinoma Associated with Bile Duct Tumor Thrombus: A Real-World Retrospective Cohort StudyFeng JKSun JXLiu ZHGu JWChen ZHLiu CGuo WXShi JCheng SQJin-Kai Feng,1,* Ju-Xian Sun,1,* Zong-Han Liu,1,* Jing-Wen Gu,2,* Zhen-Hua Chen,3 Chang Liu,1 Wei-Xing Guo,1 Jie Shi,1 Shu-Qun Cheng1 1Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, People’s Republic of China; 2College of Basic Medical Sciences, Second Military Medical University, Shanghai, People’s Republic of China; 3Department of General Surgery, Zhejiang Provincial Armed Police Corps Hospital, Hangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shu-Qun ChengDepartment of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, Shanghai, 200433, People’s Republic of ChinaTel +86 21- 81875251Fax +86 21- 65562400Email chengshuqun@aliyun.comBackground: The occurrence of hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) is rare. The aim of the study was to evaluate the effectiveness and safety of transarterial chemoembolization (TACE) for patients with unresectable HCC with BDTT.Methods: This retrospective study was conducted on newly diagnosed HCC and BDTT patients who were initially treated with TACE or conservative management (CM) from 2009 to 2018. Survival outcomes of patients treated with TACE were compared with those of patients given CM. Multivariate analyses were performed to identify independent prognostic factors related to survival.Results: Out of 100 patients included in this study, 40 patients underwent TACE, while the remaining 60 received CM. The median survival time of the TACE group was 8.0 months longer than that of the CM group (13.0 versus 5.0 months, P < 0.001). The 6-, 12-, 18-, 24-month overall survival (OS) rates were 90.0%, 52.5%, 22.5%, and 12.5%, respectively, for the TACE group compared with 26.7%, 8.3%, 5.0%, and 3.3%, respectively, for the CM group. Multivariate analyses showed that treatment allocation (hazard ratio [HR], 0.421; 95% confidence interval [CI], 0.243– 0.730; P = 0.002), Child–Pugh status (HR, 2.529; 95% CI, 1.300– 4.920; P = 0.006) and total bilirubin level (HR, 1.007; 95% CI, 1.004– 1.009; P < 0.001) on first admission were independent predictors of OS. There was no procedure-related mortality within one month after TACE treatment.Conclusion: TACE is a safe and effective treatment method that may improve the OS of patients with unresectable HCC with BDTT.Keywords: hepatocellular carcinoma, bile duct tumor thrombus, transarterial chemoembolization, conservative management, overall survivalhttps://www.dovepress.com/efficacy-and-safety-of-transarterial-chemoembolization-for-the-treatme-peer-reviewed-fulltext-article-CMARhepatocellular carcinomabile duct tumor thrombustransarterial chemoembolizationconservative managementoverall survival |
| spellingShingle | Feng JK Sun JX Liu ZH Gu JW Chen ZH Liu C Guo WX Shi J Cheng SQ Efficacy and Safety of Transarterial Chemoembolization for the Treatment of Unresectable Hepatocellular Carcinoma Associated with Bile Duct Tumor Thrombus: A Real-World Retrospective Cohort Study Cancer Management and Research hepatocellular carcinoma bile duct tumor thrombus transarterial chemoembolization conservative management overall survival |
| title | Efficacy and Safety of Transarterial Chemoembolization for the Treatment of Unresectable Hepatocellular Carcinoma Associated with Bile Duct Tumor Thrombus: A Real-World Retrospective Cohort Study |
| title_full | Efficacy and Safety of Transarterial Chemoembolization for the Treatment of Unresectable Hepatocellular Carcinoma Associated with Bile Duct Tumor Thrombus: A Real-World Retrospective Cohort Study |
| title_fullStr | Efficacy and Safety of Transarterial Chemoembolization for the Treatment of Unresectable Hepatocellular Carcinoma Associated with Bile Duct Tumor Thrombus: A Real-World Retrospective Cohort Study |
| title_full_unstemmed | Efficacy and Safety of Transarterial Chemoembolization for the Treatment of Unresectable Hepatocellular Carcinoma Associated with Bile Duct Tumor Thrombus: A Real-World Retrospective Cohort Study |
| title_short | Efficacy and Safety of Transarterial Chemoembolization for the Treatment of Unresectable Hepatocellular Carcinoma Associated with Bile Duct Tumor Thrombus: A Real-World Retrospective Cohort Study |
| title_sort | efficacy and safety of transarterial chemoembolization for the treatment of unresectable hepatocellular carcinoma associated with bile duct tumor thrombus a real world retrospective cohort study |
| topic | hepatocellular carcinoma bile duct tumor thrombus transarterial chemoembolization conservative management overall survival |
| url | https://www.dovepress.com/efficacy-and-safety-of-transarterial-chemoembolization-for-the-treatme-peer-reviewed-fulltext-article-CMAR |
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